NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 1

The Week 1 NFL slate has plenty of quality competition in store. Among those games is the San Francisco 49ers squaring off against the Los Angeles Rams.

Here's everything you need to know about the betting odds for Week 1 in the NFL.

Seahawks vs. Patriots

The 2026 NFL season begins on Wednesday, Sept. 9 for the Seattle Seahawks (0-0) and the New England Patriots (0-0), who meet for a Week 1 matchup at Lumen Field at 8:20 p.m. ET. The Seahawks start their campaign after they won the Super Bowl and had a 14-3 record in 2025, while the Patriots went 14-3 last season and lost the Super Bowl.

• Game Preview: New England Patriots at Seattle Seahawks
• Projected Favorite: Seahawks (60.08% win probability)
• Spread: Seattle (-3.5)
• Total: 44.5 -- Over: (-110) | Under: (-110)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Seattle vs. New England with FanDuel Sportsbook.

Rams vs. 49ers

Two of last season's best offensive players will be featured when wideout Puka Nacua and the Los Angeles Rams take on running back Christian McCaffrey and the San Francisco 49ers on Thursday, September 10, 2026.

• Game Preview: San Francisco 49ers vs. Los Angeles Rams
• Projected Favorite: Rams (62.49% win probability)
• Spread: Los Angeles (-3.5)
• Total: 47.5 -- Over: (-114) | Under: (-106)
• Time: 8:35 p.m. ET
• Channel: Netflix

Bet on Los Angeles vs. San Francisco with FanDuel Sportsbook.

Jaguars vs. Browns

The Jacksonville Jaguars (0-0) host the Cleveland Browns (0-0) at EverBank Stadium on Sunday, Sept. 13 at 1 p.m. ET to kick off the 2026 NFL season.

• Game Preview: Cleveland Browns at Jacksonville Jaguars
• Projected Favorite: Jaguars (77.84% win probability)
• Spread: Jacksonville (-8.5)
• Total: 40.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Jacksonville vs. Cleveland with FanDuel Sportsbook.

Bengals vs. Buccaneers

The 2026 NFL season kicks off on Sunday, Sept. 13 for the Cincinnati Bengals (0-0) and the Tampa Bay Buccaneers (0-0), who square off in a Week 1 matchup at Paycor Stadium at 1 p.m. ET. The Bengals start their campaign after they missed the playoffs and had a 6-11 record in 2025, while the Buccaneers went 8-9 last season and missed the playoffs.

• Game Preview: Tampa Bay Buccaneers at Cincinnati Bengals
• Projected Favorite: Bengals (52.88% win probability)
• Spread: Cincinnati (-3.5)
• Total: 50.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Cincinnati vs. Tampa Bay with FanDuel Sportsbook.

Titans vs. Jets

The Tennessee Titans (0-0) host the New York Jets (0-0) at Nissan Stadium on Sunday, Sept. 13 at 1 p.m. ET to kick off the 2026 NFL season. Last year the Titans missed the playoffs after a 3-14 season, while the Jets went 3-14 and missed the playoffs.

• Game Preview: New York Jets at Tennessee Titans
• Projected Favorite: Titans (52.83% win probability)
• Spread: Tennessee (-1.5)
• Total: 38.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tennessee vs. New York with FanDuel Sportsbook.

Lions vs. Saints

Two of last year's top offensive performers will be on display when running back Jahmyr Gibbs and the Detroit Lions host Chris Olave and the New Orleans Saints on Sunday, September 13, 2026.

• Game Preview: New Orleans Saints at Detroit Lions
• Projected Favorite: Lions (70.00% win probability)
• Spread: Detroit (-6.5)
• Total: 49.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Detroit vs. New Orleans with FanDuel Sportsbook.

Texans vs. Bills

Two of last year's best offensive performers will be on show when running back James Cook and the Buffalo Bills visit Nico Collins and the Houston Texans on Sunday, September 13, 2026.

• Game Preview: Buffalo Bills at Houston Texans
• Projected Favorite: Bills (52.23% win probability)
• Spread: Buffalo (-1.5)
• Total: 44.5 -- Over: (-118) | Under: (-104)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Houston vs. Buffalo with FanDuel Sportsbook.

Colts vs. Ravens

The 2026 NFL season begins on Sunday, Sept. 13 for the Baltimore Ravens (0-0) and the Indianapolis Colts (0-0), who take the field in a Week 1 matchup at Lucas Oil Stadium at 1 p.m. ET. Both teams finished 8-9 a season ago.

• Game Preview: Baltimore Ravens at Indianapolis Colts
• Projected Favorite: Ravens (57.21% win probability)
• Spread: Baltimore (-3.5)
• Total: 47.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Indianapolis vs. Baltimore with FanDuel Sportsbook.

Steelers vs. Falcons

One of the top pass-catchers in football last season will be on display when Kyle Pitts and the Atlanta Falcons visit the Pittsburgh Steelers on Sunday, September 13, 2026.

• Game Preview: Atlanta Falcons at Pittsburgh Steelers
• Projected Favorite: Steelers (59.62% win probability)
• Spread: Pittsburgh (-4.5)
• Total: 41.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Pittsburgh vs. Atlanta with FanDuel Sportsbook.

Panthers vs. Bears

The Chicago Bears (0-0) visit the Carolina Panthers (0-0) at Bank of America Stadium on Sunday, Sept. 13 at 1 p.m. ET to begin the 2026 NFL season.

• Game Preview: Chicago Bears at Carolina Panthers
• Projected Favorite: Bears (55.18% win probability)
• Spread: Chicago (-3)
• Total: 47.5 -- Over: (-102) | Under: (-120)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Chicago with FanDuel Sportsbook.

Chargers vs. Cardinals

One of the best pass-catchers in football last season will be featured when Trey McBride and the Arizona Cardinals visit the Los Angeles Chargers on Sunday, September 13, 2026.

• Game Preview: Arizona Cardinals at Los Angeles Chargers
• Projected Favorite: Chargers (76.31% win probability)
• Spread: Los Angeles (-9.5)
• Total: 47.5 -- Over: (-102) | Under: (-120)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Los Angeles vs. Arizona with FanDuel Sportsbook.

Raiders vs. Dolphins

The 2026 NFL season starts on Sunday, Sept. 13 for the Las Vegas Raiders (0-0) and the Miami Dolphins (0-0), who square off in a Week 1 matchup at Allegiant Stadium at 4:25 p.m. ET. The Raiders were 3-14 last year, while the Dolphins put up a 7-10 record in 2025.

• Game Preview: Miami Dolphins at Las Vegas Raiders
• Projected Favorite: Dolphins (50.71% win probability)
• Spread: Las Vegas (-3)
• Total: 39.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Las Vegas vs. Miami with FanDuel Sportsbook.

Eagles vs. Commanders

The Washington Commanders are in action on Sunday at 4:25 p.m. ET at Lincoln Financial Field against the Philadelphia Eagles.

• Game Preview: Washington Commanders at Philadelphia Eagles
• Projected Favorite: Eagles (69.94% win probability)
• Spread: Philadelphia (-5.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. Washington with FanDuel Sportsbook.

Vikings vs. Packers

The Minnesota Vikings (0-0) host the Green Bay Packers (0-0) at U.S. Bank Stadium on Sunday, Sept. 13 at 4:25 p.m. ET to start the 2026 NFL season. Last year the Vikings missed the playoffs after a 9-8 season, while the Packers finished 9-7-1 and lost in the Wild Card round.

• Game Preview: Green Bay Packers at Minnesota Vikings
• Projected Favorite: Packers (52.76% win probability)
• Spread: Minnesota (-1.5)
• Total: 46.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Minnesota vs. Green Bay with FanDuel Sportsbook.

Giants vs. Cowboys

The 2026 NFL season begins on Sunday, Sept. 13 for the Dallas Cowboys (0-0) and the New York Giants (0-0), who take the field for a Week 1 matchup at MetLife Stadium at 8:20 p.m. ET. The Cowboys start their campaign after they missed the playoffs and had a 7-9-1 record in 2025, while the Giants went 4-13 last year and missed the playoffs.

• Game Preview: Dallas Cowboys at New York Giants
• Projected Favorite: Cowboys (61.32% win probability)
• Spread: Dallas (-2.5)
• Total: 48.5 -- Over: (-105) | Under: (-115)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on New York vs. Dallas with FanDuel Sportsbook.

Chiefs vs. Broncos

A pair of last season's top offensive performers will be on display when wide receiver Travis Kelce and the Kansas City Chiefs host QB Bo Nix and the Denver Broncos on Monday, September 14, 2026.

• Game Preview: Denver Broncos at Kansas City Chiefs
• Projected Favorite: Chiefs (52.28% win probability)
• Spread: Kansas City (-2.5)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: ABC/ESPN

Bet on Kansas City vs. Denver with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!