NFL Games This Sunday: Predictions, Odds, Picks, Best Bets for Week 2

The Week 2 NFL Sunday slate has plenty of quality competition in store. Among those contests is the Minnesota Vikings playing the Chicago Bears.

With Sunday upon us in Week 2 of the NFL season, stay on top of the latest betting trends with our preview below.

Falcons vs. Panthers

At Mercedes-Benz Stadium on Sunday, Jalen Coker and the Carolina Panthers (0-1) face Bijan Robinson and the Atlanta Falcons (0-1) in a matchup between a pair of the biggest stars in football, starting at 1 p.m. ET.

• Game Preview: Carolina Panthers at Atlanta Falcons
• Projected Favorite: Panthers (53.03% win probability)
• Spread: Carolina (-2.5)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Atlanta vs. Carolina with FanDuel Sportsbook.

Patriots vs. Steelers

The New England Patriots (0-1) play on Sunday at 1 p.m. ET against the Pittsburgh Steelers (1-0) at Gillette Stadium.

• Game Preview: Pittsburgh Steelers at New England Patriots
• Projected Favorite: Patriots (72.88% win probability)
• Spread: New England (-5.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New England vs. Pittsburgh with FanDuel Sportsbook.

Buccaneers vs. Browns

Raymond James Stadium is the venue where the Tampa Bay Buccaneers (0-1) will match up against the Cleveland Browns (0-1) on Sunday, September 20, 2026.

• Game Preview: Cleveland Browns at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (67.77% win probability)
• Spread: Tampa Bay (-8.5)
• Total: 41.5 -- Over: (-102) | Under: (-120)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tampa Bay vs. Cleveland with FanDuel Sportsbook.

Jets vs. Packers

When the Green Bay Packers (0-1) and the New York Jets (1-0) play on Sunday, Sept. 20 at 1 p.m. ET, the Packers will be trying to bounce back from a loss to the Vikings, and the Jets will be looking to follow up their recent victory over the Titans with another win.

• Game Preview: Green Bay Packers at New York Jets
• Projected Favorite: Packers (64.04% win probability)
• Spread: Green Bay (-3.5)
• Total: 44.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. Green Bay with FanDuel Sportsbook.

Ravens vs. Saints

The Baltimore Ravens (1-0), who defeated the Colts in their last tilt, host the New Orleans Saints (0-1) at M&T Bank Stadium on Sept. 20 at 1 p.m. ET. The Saints were taken down by the Lions in their last game.

• Game Preview: New Orleans Saints at Baltimore Ravens
• Projected Favorite: Ravens (72.49% win probability)
• Spread: Baltimore (-8.5)
• Total: 45.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Baltimore vs. New Orleans with FanDuel Sportsbook.

Titans vs. Eagles

The Philadelphia Eagles (1-0) are set to collide with the Tennessee Titans (0-1) at Nissan Stadium on Sunday, Sept. 20 at 1 p.m. ET. In their previous games, the Eagles took down the Commanders 24-22, and the Titans lost 23-10 to the Jets.

• Game Preview: Philadelphia Eagles at Tennessee Titans
• Projected Favorite: Eagles (73.15% win probability)
• Spread: Philadelphia (-7)
• Total: 39.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tennessee vs. Philadelphia with FanDuel Sportsbook.

Bears vs. Vikings

Caleb Williams and the Chicago Bears (1-0) will host Justin Jefferson and the Minnesota Vikings (1-0) on Sunday at 1 p.m. ET, in a matchup between a pair of the brightest stars in football on offense.

• Game Preview: Minnesota Vikings at Chicago Bears
• Projected Favorite: Bears (66.38% win probability)
• Spread: Chicago (-4.5)
• Total: 47.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Chicago vs. Minnesota with FanDuel Sportsbook.

Texans vs. Bengals

After going down 36-31 to the Bills in their previous game, the Houston Texans (0-1) will host the Cincinnati Bengals (1-0), who are coming off a 33-27 victory against the Buccaneers. Kickoff is scheduled for 1 p.m. ET on Sunday, Sept. 20.

• Game Preview: Cincinnati Bengals at Houston Texans
• Projected Favorite: Texans (73.19% win probability)
• Spread: Houston (-2.5)
• Total: 45.5 -- Over: (-108) | Under: (-112)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Houston vs. Cincinnati with FanDuel Sportsbook.

Chargers vs. Raiders

One of the best pass-catchers in football will be featured when Ashton Jeanty and the Las Vegas Raiders (1-0) visit the Los Angeles Chargers (0-1) on Sunday, September 20, 2026.

• Game Preview: Las Vegas Raiders at Los Angeles Chargers
• Projected Favorite: Chargers (77.67% win probability)
• Spread: Los Angeles (-6.5)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Los Angeles vs. Las Vegas with FanDuel Sportsbook.

Broncos vs. Jaguars

The Denver Broncos (0-1), who were taken down by the Chiefs in their last contest, host the Jacksonville Jaguars (1-0) at Empower Field at Mile High on Sept. 20 at 4:05 p.m. ET. The Jaguars took home the victory against the Browns in their last game.

• Game Preview: Jacksonville Jaguars at Denver Broncos
• Projected Favorite: Broncos (55.42% win probability)
• Spread: Denver (-2.5)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Denver vs. Jacksonville with FanDuel Sportsbook.

Cowboys vs. Commanders

At AT&T Stadium on Sunday, the Dallas Cowboys (0-1) meet the Washington Commanders (0-1).

• Game Preview: Washington Commanders at Dallas Cowboys
• Projected Favorite: Cowboys (68.60% win probability)
• Spread: Dallas (-4.5)
• Total: 50.5 -- Over: (-118) | Under: (-104)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Dallas vs. Washington with FanDuel Sportsbook.

49ers vs. Dolphins

After a 27-7 victory over the Rams in their last game, the San Francisco 49ers (1-0) will host the Miami Dolphins (0-1), who are coming off a 27-13 loss to the Raiders. The game is set for 4:25 p.m. ET on Sunday, Sept. 20.

• Game Preview: Miami Dolphins at San Francisco 49ers
• Projected Favorite: 49ers (77.10% win probability)
• Spread: San Francisco (-13.5)
• Total: 45.5 -- Over: (-102) | Under: (-120)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on San Francisco vs. Miami with FanDuel Sportsbook.

Cardinals vs. Seahawks

When the Seattle Seahawks (1-0) and the Arizona Cardinals (1-0) match up on Sunday, Sept. 20 at 4:25 p.m. ET, they will both be aiming to stay on track after winning their last tilt. The Seahawks won 13-10 against the Patriots, and the Cardinals are coming off a 26-14 victory over the Chargers.

• Game Preview: Seattle Seahawks at Arizona Cardinals
• Projected Favorite: Seahawks (65.46% win probability)
• Spread: Seattle (-4.5)
• Total: 41.5 -- Over: (-102) | Under: (-120)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Arizona vs. Seattle with FanDuel Sportsbook.

Chiefs vs. Colts

The Kansas City Chiefs (1-0) are slated to match up with the Indianapolis Colts (0-1) at GEHA Field at Arrowhead Stadium on Sunday, Sept. 20 at 8:20 p.m. ET. In their previous tilts, the Chiefs defeated the Broncos 31-10, and the Colts lost 41-23 to the Ravens.

• Game Preview: Indianapolis Colts at Kansas City Chiefs
• Projected Favorite: Chiefs (58.58% win probability)
• Spread: Kansas City (-6.5)
• Total: 45.5 -- Over: (-115) | Under: (-105)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Kansas City vs. Indianapolis with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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