Nebraska vs Illinois Prediction, Odds, Picks, Best Bets for Week 10 2026

The Nebraska Cornhuskers versus the Illinois Fighting Illini is on the college football schedule for Friday.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Nebraska vs Illinois Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Nebraska: (-188) | Illinois: (+158)
• Spread: Nebraska: -4.5 (-108) | Illinois: +4.5 (-112)
• Total: 50.5 -- Over: (-110) | Under: (-110)

Nebraska vs Illinois Betting Trends

• Nebraska has six wins in eight games against the spread this year.
• Nebraska owns an ATS record of 4-2 as 4.5-point or greater favorites.
• This season, three of Nebraska's eight games have go over the point total.
• Against the spread, Illinois is 4-4-0 this year.
• Illinois has covered every time (2-0) as a 4.5-point or greater underdog this season.
• This year, five of Illinois' eight games have gone over the point total.

Nebraska vs Illinois Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cornhuskers win (73.5%)

Nebraska vs Illinois Point Spread

Nebraska is favored by 4.5 points versus Illinois. Nebraska is -108 to cover the spread, while Illinois is -112.

Nebraska vs Illinois Over/Under

Nebraska versus Illinois on Nov. 6 has an over/under of 50.5 points, with the over -110 and the under -110.

Nebraska vs Illinois Moneyline

Nebraska is the favorite, -188 on the moneyline, while Illinois is a +158 underdog.

Nebraska vs. Illinois Points Insights

Nebraska vs. Illinois Game Info

• Game day: Friday, November 6, 2026
• Game time: 8 p.m. ET
• TV channel: FOX
• Location: Champaign, Illinois
• Stadium: Gies Memorial Stadium (Champaign, IL)

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Check out even more in-depth Nebraska vs. Illinois analysis on FanDuel Research.