Chiefs vs Colts Prediction, Odds, Picks, Best Bets for NFL Week 2

The Kansas City Chiefs versus the Indianapolis Colts is on the NFL schedule for Sunday.

Get the latest NFL odds ahead of this matchup on FanDuel Sportsbook.

Chiefs vs Colts Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Chiefs win (58.6%)

Chiefs vs Colts Point Spread

The Chiefs are 6.5-point favorites against the Colts. The Chiefs are -115 to cover the spread, while the Colts are -105 to cover as a 6.5-point underdog.

Chiefs vs Colts Over/Under

The over/under for the Chiefs versus Colts matchup on Sept. 20 has been set at 46.5, with -110 odds on the over and -110 odds on the under.

Chiefs vs Colts Moneyline

Kansas City is the favorite, -330 on the moneyline, while Indianapolis is a +265 underdog on the road.

Chiefs vs Colts Betting Trends

• Against the spread, the Chiefs were 6-11-0 last year.
• The Chiefs did not lose ATS (2-0) as a 6.5-point favorite or more last season.
• There were four Kansas City games (out of 17) that hit the over last season.
• Against the spread, the Colts were 9-8-0 last year.
• Indianapolis covered every time (2-0) as underdogs of 6.5 points or greater last year.
• In 17 Colts games last season, nine of them hit the over.

Check out even more in-depth Chiefs vs. Colts analysis on FanDuel Research.

Chiefs vs Colts Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-330) | IND: (+265)
• Spread: KC: -6.5 (-115) | IND: +6.5 (-105)
• Total: 46.5 -- Over: (-110) | Under: (-110)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!