SMU vs Virginia Tech Prediction, Odds, Picks, Best Bets for Week 10 2026

The SMU Mustangs versus the Virginia Tech Hokies is on the college football schedule for Friday.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

SMU vs Virginia Tech Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SMU: (-215) | Virginia Tech: (+176)
• Spread: SMU: -5.5 (-118) | Virginia Tech: +5.5 (-104)
• Total: 56.5 -- Over: (-110) | Under: (-110)

SMU vs Virginia Tech Betting Trends

• SMU has three wins in eight games against the spread this season.
• Against the spread as 5.5-point or better favorites, SMU is 3-3.
• This season, three of SMU's eight games have hit the over.
• Against the spread, Virginia Tech is 5-3-0 this season.
• Virginia Tech has seen five of its eight games go over the point total.

SMU vs Virginia Tech Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Mustangs win (69.5%)

SMU vs Virginia Tech Point Spread

SMU is favored by 5.5 points over Virginia Tech. SMU is -118 to cover the spread, with Virginia Tech being -104.

SMU vs Virginia Tech Over/Under

The over/under for the SMU versus Virginia Tech matchup on Nov. 6 has been set at 56.5, with -110 odds on the over and -110 odds on the under.

SMU vs Virginia Tech Moneyline

The SMU vs Virginia Tech moneyline has SMU as a -215 favorite, while Virginia Tech is a +176 underdog.

SMU vs. Virginia Tech Points Insights

SMU vs. Virginia Tech Game Info

• Game day: Friday, November 6, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: University Park, Texas
• Stadium: Gerald J. Ford Stadium

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Check out even more in-depth SMU vs. Virginia Tech analysis on FanDuel Research.