Wednesday’s MLB Strikeout Props - April 22

Will Shohei Ohtani strike out more than 6.5 batters? Can Tomoyuki Sugano exceed 2.5 strikeouts? See their odds and more strikeout prop odds for all pitchers in MLB play on April 22, in the article below.

Today's MLB Strikeout Props

Cincinnati Reds at Tampa Bay Rays

• Nick Martínez (Rays): Over/Under 4.5 Ks (Over +118, Under -158) | 2026 Stats: 4 strikeouts per game in 5 appearances
• Brandon Williamson (Reds): Over/Under 3.5 Ks (Over +102, Under -136) | 2026 Stats: 3 strikeouts per game in 5 appearances

Toronto Blue Jays at Los Angeles Angels

• Eric Lauer (Blue Jays): Over/Under 4.5 Ks (Over -120, Under -110) | 2026 Stats: 3.8 strikeouts per game in 5 appearances
• Jack Kochanowicz (Angels): Over/Under 3.5 Ks (Over +116, Under -154) | 2026 Stats: 3.8 strikeouts per game in 5 appearances
• Patrick Corbin (Blue Jays): Over/Under 4.5 Ks (Over -108, Under -122) | 2026 Stats: 4 strikeouts per game in 3 appearances
• José Soriano (Angels): Over/Under 5.5 Ks (Over -118, Under -112) | 2026 Stats: 7.2 strikeouts per game in 6 appearances

San Diego Padres at Colorado Rockies

• Walker Buehler (Padres): Over/Under 3.5 Ks (Over -144, Under +108) | 2026 Stats: 4.5 strikeouts per game in 4 appearances
• Tomoyuki Sugano (Rockies): Over/Under 2.5 Ks (Over -186, Under +138) | 2026 Stats: 3.8 strikeouts per game in 4 appearances

Athletics at Seattle Mariners

• Aaron Civale (Athletics): Over/Under 4.5 Ks (Over -146, Under +110) | 2026 Stats: 4.2 strikeouts per game in 5 appearances
• Luis Castillo (Mariners): Over/Under 5.5 Ks (Over -106, Under -125) | 2026 Stats: 4.6 strikeouts per game in 5 appearances
• Logan Gilbert (Mariners): Over/Under 6.5 Ks (Over -125, Under -106) | 2026 Stats: 5.8 strikeouts per game in 6 appearances
• Jacob Lopez (Athletics): Over/Under 5.5 Ks (Over -112, Under -118) | 2026 Stats: 3.4 strikeouts per game in 5 appearances

St. Louis Cardinals at Miami Marlins

• Kyle Leahy (Cardinals): Over/Under 3.5 Ks (Over -114, Under -114) | 2026 Stats: 3 strikeouts per game in 5 appearances
• Janson Junk (Marlins): Over/Under 3.5 Ks (Over -158, Under +118) | 2026 Stats: 3.4 strikeouts per game in 5 appearances

Houston Astros at Cleveland Guardians

• Tanner Bibee (Guardians): Over/Under 4.5 Ks (Over -158, Under +118) | 2026 Stats: 4.3 strikeouts per game in 6 appearances
• Peter Lambert (Astros): Over/Under 3.5 Ks (Over -136, Under +102) | 2026 Stats: 8 strikeouts per game in 2 appearances

Pittsburgh Pirates at Texas Rangers

• Jack Leiter (Rangers): Over/Under 5.5 Ks (Over -120, Under -110) | 2026 Stats: 6 strikeouts per game in 4 appearances
• Braxton Ashcraft (Pirates): Over/Under 5.5 Ks (Over -102, Under -130) | 2026 Stats: 6.8 strikeouts per game in 4 appearances

Baltimore Orioles at Kansas City Royals

• Michael Wacha (Royals): Over/Under 5.5 Ks (Over +126, Under -168) | 2026 Stats: 5.6 strikeouts per game in 5 appearances

Chicago White Sox at Arizona Diamondbacks

• Eduardo Rodríguez (Diamondbacks): Over/Under 4.5 Ks (Over -118, Under -112) | 2026 Stats: 3.5 strikeouts per game in 4 appearances
• Anthony Kay (White Sox): Over/Under 3.5 Ks (Over +112, Under -148) | 2026 Stats: 3 strikeouts per game in 4 appearances

Los Angeles Dodgers at San Francisco Giants

• Tyler Mahle (Giants): Over/Under 4.5 Ks (Over -106, Under -125) | 2026 Stats: 5.2 strikeouts per game in 4 appearances
• Shohei Ohtani (Dodgers): Over/Under 6.5 Ks (Over +100, Under -132) | 2026 Stats: 6 strikeouts per game in 3 appearances