Wednesday’s MLB Odds, Betting Lines and Predictions - April 22

Wednesday's MLB slate has several top-tier games, including a matchup between the Atlanta Braves and the Washington Nationals. Below, we have predictions for every game.

Today's MLB Odds and Predictions

St. Louis Cardinals at Miami Marlins Odds, Lines & Predictions

Game Info

• When: 12:10 p.m. ET
• Where: loanDepot park
• TV Channel: MIAM and CARD
• Probable Pitchers: Janson Junk vs. Kyle Leahy
• Records: Marlins (11-12), Cardinals (13-9)
• Marlins Moneyline Odds: -130
• Cardinals Moneyline Odds: +110

numberFire Prediction

• numberFire Predicted Favorite: Marlins
• Marlins Win Probability: 57.79%
• Cardinals Win Probability: 42.21%

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Cincinnati Reds at Tampa Bay Rays Odds, Lines & Predictions

Game Info

• When: 1:10 p.m. ET
• Where: Tropicana Field
• TV Channel: RAYS and CINR
• Probable Pitchers: Nick Martínez vs. Brandon Williamson
• Records: Rays (12-10), Reds (15-8)
• Rays Moneyline Odds: -126
• Reds Moneyline Odds: +108

numberFire Prediction

• numberFire Predicted Favorite: Rays
• Rays Win Probability: 59.39%
• Reds Win Probability: 40.61%

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Houston Astros at Cleveland Guardians Odds, Lines & Predictions

Game Info

• When: 1:10 p.m. ET
• Where: Progressive Field
• TV Channel: CLEG and SCHN
• Probable Pitchers: Tanner Bibee vs. Peter Lambert
• Records: Guardians (13-11), Astros (9-15)
• Guardians Moneyline Odds: -130
• Astros Moneyline Odds: +110

numberFire Prediction

• numberFire Predicted Favorite: Astros
• Astros Win Probability: 50.70%
• Guardians Win Probability: 49.30%

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Baltimore Orioles at Kansas City Royals Odds, Lines & Predictions

Game Info

• When: 2:10 p.m. ET
• Where: Kauffman Stadium
• TV Channel: ROYL and MASN
• Probable Pitchers: Michael Wacha vs. Chris Bassitt
• Records: Royals (7-16), Orioles (11-12)
• Royals Moneyline Odds: -124
• Orioles Moneyline Odds: +106

numberFire Prediction

• numberFire Predicted Favorite: Royals
• Royals Win Probability: 56.42%
• Orioles Win Probability: 43.58%

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Toronto Blue Jays at Los Angeles Angels Odds, Lines & Predictions

Game Info

• When: 3:07 p.m. ET
• Where: Angel Stadium
• TV Channel: FDSW and SNET
• Probable Pitchers: José Soriano vs. Eric Lauer
• Records: Angels (11-13), Blue Jays (9-13)
• Angels Moneyline Odds: -152
• Blue Jays Moneyline Odds: +128

numberFire Prediction

• numberFire Predicted Favorite: Blue Jays
• Blue Jays Win Probability: 53.76%
• Angels Win Probability: 46.24%

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Athletics at Seattle Mariners Odds, Lines & Predictions

Game Info

• When: 4:10 p.m. ET
• Where: T-Mobile Park
• TV Channel: SEAM and NBCS-CA
• Probable Pitchers: Logan Gilbert vs. Aaron Civale
• Records: Mariners (10-14), Athletics (12-11)
• Mariners Moneyline Odds: -200
• Athletics Moneyline Odds: +168

numberFire Prediction

• numberFire Predicted Favorite: Mariners
• Mariners Win Probability: 61.28%
• Athletics Win Probability: 38.72%

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Milwaukee Brewers at Detroit Tigers Odds, Lines & Predictions

Game Info

• When: 6:40 p.m. ET
• Where: Comerica Park
• TV Channel: DSN and BREW
• Probable Pitchers: Casey Mize vs. Chad Patrick
• Records: Tigers (12-11), Brewers (12-9)
• Tigers Moneyline Odds: -132
• Brewers Moneyline Odds: +112

numberFire Prediction

• numberFire Predicted Favorite: Brewers
• Brewers Win Probability: 50.26%
• Tigers Win Probability: 49.74%

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New York Yankees at Boston Red Sox Odds, Lines & Predictions

Game Info

• When: 6:45 p.m. ET
• Where: Fenway Park
• TV Channel: MLB Network and NESN and Amazon Prime Video
• Probable Pitchers: Ranger Suarez vs. Max Fried
• Records: Red Sox (9-13), Yankees (13-9)
• Yankees Moneyline Odds: -152
• Red Sox Moneyline Odds: +128

numberFire Prediction

• numberFire Predicted Favorite: Yankees
• Yankees Win Probability: 50.81%
• Red Sox Win Probability: 49.19%

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Atlanta Braves at Washington Nationals Odds, Lines & Predictions

Game Info

• When: 6:45 p.m. ET
• Where: Nationals Park
• TV Channel: NATS and BravesVsn
• Probable Pitchers: Zack Littell vs. Martín Pérez
• Records: Nationals (10-13), Braves (16-7)
• Braves Moneyline Odds: -138
• Nationals Moneyline Odds: +118

numberFire Prediction

• numberFire Predicted Favorite: Braves
• Braves Win Probability: 57.36%
• Nationals Win Probability: 42.64%

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Minnesota Twins at New York Mets

Game Info

• When: 7:10 p.m. ET
• Where: Citi Field
• TV Channel: SNY and MNNT
• Probable Pitchers: Clay Holmes vs.
• Records: Mets (7-15), Twins (11-11)

numberFire Prediction

• numberFire Predicted Favorite: Mets
• Mets Win Probability: 61.74%
• Twins Win Probability: 38.26%

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Philadelphia Phillies at Chicago Cubs

Game Info

• When: 7:40 p.m. ET
• Where: Wrigley Field
• TV Channel: MARQ and NBCS-PH+
• Probable Pitchers: Matthew Boyd vs.
• Records: Cubs (13-9), Phillies (8-14)

numberFire Prediction

• numberFire Predicted Favorite: Cubs
• Cubs Win Probability: 63.79%
• Phillies Win Probability: 36.21%

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Pittsburgh Pirates at Texas Rangers Odds, Lines & Predictions

Game Info

• When: 8:05 p.m. ET
• Where: Globe Life Field
• TV Channel: RSN and SportsNet PT+
• Probable Pitchers: Jack Leiter vs. Braxton Ashcraft
• Records: Rangers (11-11), Pirates (13-9)
• Rangers Moneyline Odds: -108
• Pirates Moneyline Odds: -108

numberFire Prediction

• numberFire Predicted Favorite: Rangers
• Rangers Win Probability: 51.06%
• Pirates Win Probability: 48.94%

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San Diego Padres at Colorado Rockies Odds, Lines & Predictions

Game Info

• When: 8:40 p.m. ET
• Where: Coors Field
• TV Channel: COLR and SDPA
• Probable Pitchers: Tomoyuki Sugano vs. Walker Buehler
• Records: Rockies (9-14), Padres (15-7)
• Padres Moneyline Odds: -168
• Rockies Moneyline Odds: +142

numberFire Prediction

• numberFire Predicted Favorite: Padres
• Padres Win Probability: 66.62%
• Rockies Win Probability: 33.38%

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Chicago White Sox at Arizona Diamondbacks Odds, Lines & Predictions

Game Info

• When: 9:40 p.m. ET
• Where: Chase Field
• TV Channel: ARID and CHSN
• Probable Pitchers: Eduardo Rodríguez vs. Anthony Kay
• Records: Diamondbacks (13-9), White Sox (8-14)
• Diamondbacks Moneyline Odds: -152
• White Sox Moneyline Odds: +128

numberFire Prediction

• numberFire Predicted Favorite: Diamondbacks
• Diamondbacks Win Probability: 64.92%
• White Sox Win Probability: 35.08%

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Los Angeles Dodgers at San Francisco Giants Odds, Lines & Predictions

Game Info

• When: 9:45 p.m. ET
• Where: Oracle Park
• TV Channel: NBCS-BA and SportsNet LA
• Probable Pitchers: Tyler Mahle vs. Shohei Ohtani
• Records: Giants (9-13), Dodgers (16-6)
• Dodgers Moneyline Odds: -225
• Giants Moneyline Odds: +188

numberFire Prediction

• numberFire Predicted Favorite: Dodgers
• Dodgers Win Probability: 60.22%
• Giants Win Probability: 39.78%

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All MLB win probability predictions and picks are according to numberFire.