Monday’s MLB Odds, Betting Lines and Predictions - April 21

Monday's MLB slate features the Milwaukee Brewers taking on the San Francisco Giants at Oracle Park. We have predictions for every game on the schedule, so take a look below.
Today's MLB Odds and Predictions
Chicago White Sox at Boston Red Sox Odds, Lines & Predictions
Game Info
- When: 11:10 AM ET
- Where: Fenway Park
- TV Channel: MLB Network, NESN and CHSN
- Probable Pitchers: Walker Anthony Buehler vs. Jonathan Cannon
- Records: Red Sox (13-11), White Sox (5-17)
- Red Sox Moneyline Odds: -295
- White Sox Moneyline Odds: +240
numberFire Prediction
- numberFire Predicted Favorite: Red Sox
- Red Sox Win Probability: 59.50%
- White Sox Win Probability: 40.50%
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New York Yankees at Cleveland Guardians Odds, Lines & Predictions
Game Info
- When: 6:10 PM ET
- Where: Progressive Field
- TV Channel: CLEG and YES
- Probable Pitchers: Gavin Williams vs. Clarke Schmidt
- Records: Guardians (13-9), Yankees (14-9)
- Yankees Moneyline Odds: -124
- Guardians Moneyline Odds: +106
numberFire Prediction
- numberFire Predicted Favorite: Yankees
- Yankees Win Probability: 54.15%
- Guardians Win Probability: 45.85%
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Cincinnati Reds at Miami Marlins Odds, Lines & Predictions
Game Info
- When: 6:40 PM ET
- Where: loanDepot park
- TV Channel: FDSFL and FDSOH
- Probable Pitchers: Max Meyer vs. Nick Lodolo
- Records: Marlins (9-12), Reds (11-11)
- Reds Moneyline Odds: -120
- Marlins Moneyline Odds: +102
numberFire Prediction
- numberFire Predicted Favorite: Reds
- Reds Win Probability: 58.56%
- Marlins Win Probability: 41.44%
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San Diego Padres at Detroit Tigers Odds, Lines & Predictions
Game Info
- When: 6:40 PM ET
- Where: Comerica Park
- TV Channel: Fox Sports 1, FDSDETX and SDPA
- Probable Pitchers: Keider Montero vs. Randy Vasquez
- Records: Tigers (13-9), Padres (16-6)
- Tigers Moneyline Odds: -142
- Padres Moneyline Odds: +120
numberFire Prediction
- numberFire Predicted Favorite: Padres
- Padres Win Probability: 56.70%
- Tigers Win Probability: 43.30%
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Philadelphia Phillies at New York Mets Odds, Lines & Predictions
Game Info
- When: 7:10 PM ET
- Where: Citi Field
- TV Channel: SNY and NBCS-PH
- Probable Pitchers: Tylor Megill vs. Aaron Nola
- Records: Mets (15-7), Phillies (13-9)
- Mets Moneyline Odds: -134
- Phillies Moneyline Odds: +116
numberFire Prediction
- numberFire Predicted Favorite: Mets
- Mets Win Probability: 53.37%
- Phillies Win Probability: 46.63%
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St. Louis Cardinals at Atlanta Braves Odds, Lines & Predictions
Game Info
- When: 7:15 PM ET
- Where: Truist Park
- TV Channel: FDSSO and FDSMWX
- Probable Pitchers: Spencer Schwellenbach vs. Erick Fedde
- Records: Braves (8-13), Cardinals (9-13)
- Braves Moneyline Odds: -215
- Cardinals Moneyline Odds: +180
numberFire Prediction
- numberFire Predicted Favorite: Braves
- Braves Win Probability: 64.07%
- Cardinals Win Probability: 35.93%
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Toronto Blue Jays at Houston Astros Odds, Lines & Predictions
Game Info
- When: 8:10 PM ET
- Where: Daikin Park
- TV Channel: SCHN and SN1
- Probable Pitchers: Hunter Brown vs. Kevin Gausman
- Records: Astros (10-11), Blue Jays (12-10)
- Astros Moneyline Odds: -134
- Blue Jays Moneyline Odds: +114
numberFire Prediction
- numberFire Predicted Favorite: Astros
- Astros Win Probability: 58.15%
- Blue Jays Win Probability: 41.85%
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Milwaukee Brewers at San Francisco Giants Odds, Lines & Predictions
Game Info
- When: 9:45 PM ET
- Where: Oracle Park
- TV Channel: MLB Network, NBCS-BA and FDSWI
- Probable Pitchers: Robbie Ray vs. Quinn Priester
- Records: Giants (14-8), Brewers (12-10)
- Giants Moneyline Odds: -138
- Brewers Moneyline Odds: +118
numberFire Prediction
- numberFire Predicted Favorite: Brewers
- Brewers Win Probability: 55.44%
- Giants Win Probability: 44.56%
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All MLB win probability predictions and picks are according to numberFire.