Missouri vs South Carolina Prediction, Odds, Picks, Best Bets for Week 4 2025

The Missouri Tigers will take on the South Carolina Gamecocks in college football action on Saturday.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Missouri vs South Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Missouri: (-360) | South Carolina: (+280)
• Spread: Missouri: -9.5 (-120) | South Carolina: +9.5 (-102)
• Total: 48.5 -- Over: (-110) | Under: (-110)

Missouri vs South Carolina Betting Trends

• Missouri hasn't lost a game against the spread this year.
• Missouri is unbeaten ATS (2-0) as a 9.5-point favorite or greater this season.
• Missouri and its opponent have not failed to hit the over in any game this season.
• South Carolina has posted one win against the spread this season.
• None of South Carolina's three games has gone over the point total in 2025.

Missouri vs South Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Gamecocks win (50.4%)

Missouri vs South Carolina Point Spread

Missouri is favored by 9.5 points against South Carolina. Missouri is -120 to cover the spread, while South Carolina is -102.

Missouri vs South Carolina Over/Under

A total of 48.5 points has been set for the Missouri-South Carolina matchup on Sept. 20, with the over available at -110 and the under at -110.

Missouri vs South Carolina Moneyline

South Carolina is a +280 underdog on the moneyline, while Missouri is a -360 favorite.

Missouri vs. South Carolina Points Insights

Missouri vs. South Carolina Game Info

• Game day: Saturday, September 20, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Columbia, Missouri
• Stadium: Memorial Stadium/Faurot Field

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Check out even more in-depth Missouri vs. South Carolina analysis on FanDuel Research.