Michigan State vs Boston College Prediction, Odds, Picks, Best Bets for Week 2 2025

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College football's Saturday schedule includes the Michigan State Spartans facing the Boston College Eagles.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Michigan State vs Boston College Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Michigan State: (-172) | Boston College: (+142)
Spread: Michigan State: -3.5 (-112) | Boston College: +3.5 (-108)
Total: 45.5 -- Over: (-110) | Under: (-110)

Michigan State has no wins against the spread this year.
Michigan State has no wins ATS (0-1) as a 3.5-point favorite or greater this season.
Boston College has posted one win against the spread this year.
Every Boston College game has hit the over this season.

All college football win probability predictions and picks are according to numberFire.
Prediction: Eagles win (65.2%)

Michigan State is favored by 3.5 points versus Boston College. Michigan State is -112 to cover the spread, while Boston College is -108.

A combined point total of 45.5 has been set for Michigan State-Boston College on Sept. 6, with the over at -110 and the under at -110.

Looking at the moneyline for Michigan State-Boston College, Michigan State is the favorite at -172, and Boston College is +142.

The average implied total for the Spartans last season was 29.8 points, 4.8 more points than their implied total of 25 points in Saturday's game.
The Eagles' average implied point total last season (30.4 points) is 9.4 points higher than their implied total in this matchup (21 points).

Check out even more in-depth Michigan State vs. Boston College analysis on FanDuel Research.

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