Cubs vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for April 4

Odds updated as of 2:12 a.m.

The Saturday slate in MLB includes a matchup between the Chicago Cubs and the Cleveland Guardians.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Guardians Game Info

• Chicago Cubs (3-4) vs. Cleveland Guardians (5-3)
• Date: Saturday, April 4, 2026
• Time: 7:15 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: FOX

Cubs vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-138) | CLE: (+118)
• Spread: CHC: -1.5 (+126) | CLE: +1.5 (-152)
• Total: 8 -- Over: (-105) | Under: (-115)

Cubs vs Guardians Probable Starting Pitchers

Probable Pitchers: Shota Imanaga (Cubs) - 0-1, 7.20 ERA vs Slade Cecconi (Guardians) - 0-1, 12.46 ERA

The Cubs will give the nod to Shota Imanaga (0-1, 7.20 ERA), who is eyeing win No. 1 on the season, and the Guardians will counter with Slade Cecconi (0-1, 12.46 ERA). Imanaga and his team failed to cover the spread in his only opportunity this season as a starter. Imanaga's team lost his only start as a favorite this season. Cecconi has started just one game with a set spread, which the Guardians failed to cover. The Guardians were the moneyline underdog for one Cecconi start this season -- they lost.

Cubs vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (57.2%)

Cubs vs Guardians Moneyline

• The moneyline numbers for Cubs vs. Guardians reveal Chicago as the favorite (-138) and Cleveland as the underdog (+118) despite being the home team.

Cubs vs Guardians Spread

• The Guardians are hosting the Cubs, and are +1.5 on the runline. The Guardians are +126 to cover the spread, and the Cubs are -152.

Cubs vs Guardians Over/Under

• A total of 8 runs has been set for the Cubs-Guardians contest on April 4, with the over available at -105 and the under at -115.

Bet on Chicago Cubs vs. Cleveland Guardians on FanDuel today!

Cubs vs Guardians Betting Trends

• The Cubs have won in three of the seven contests they have been named as odds-on favorites in this year.
• Chicago has a record of 3-3 when favored by -138 or more this year.
• The Cubs and their opponents have gone over in three of their seven games with a total set by sportsbooks this season.
• The Cubs are 3-4-0 against the spread in their seven games that had a posted line this season.
• The Guardians have compiled a 5-3 record in games they were listed as the moneyline underdog (winning 62.5% of those games).
• Cleveland has a 4-3 record (winning 57.1% of its games) when playing as a moneyline underdog of +118 or longer.
• The Guardians have had an over/under set by bookmakers eight times, and have combined with opponents to go over the total in three of those games (3-5-0).
• The Guardians have gone 5-3-0 ATS this season.

Cubs Player Leaders

• Nico Hoerner leads Chicago OPS (.858) this season. He has a .292 batting average, an on-base percentage of .400, and a slugging percentage of .458.
• Among qualifying batters, he ranks 53rd in batting average, his on-base percentage ranks 36th, and he is 65th in slugging.
• Alex Bregman is batting .214 with two home runs and four walks. He's slugging .429 with an on-base percentage of .313.
• Among qualifying batters, he ranks 121st in batting average, 106th in on-base percentage and 76th in slugging percentage.
• Bregman brings a two-game streak with at least one hit into this matchup. During his last five outings he is batting .263 with two home runs, three walks and three RBIs.
• Ian Happ has five hits and is batting .179 this season.
• Michael Busch is batting .240 with a .367 OBP and one RBI for Chicago this season.

Guardians Player Leaders

• Chase DeLauter has put up a team-high OBP (.370) and slugging percentage (.923), while pacing the Guardians in hits (nine, while batting .346).
• He ranks 26th in batting average, 58th in on-base percentage and second in slugging percentage among all qualifying hitters in MLB.
• Jose Ramirez is hitting .188 with two doubles, a home run and two walks. He's slugging .344 with an on-base percentage of .235.
• Including all qualifying hitters, he is 146th in batting average, 172nd in on-base percentage and 119th in slugging percentage.
• Steven Kwan has a double and four walks while batting .233.
• Brayan Rocchio has a .370 on-base percentage to lead his team.

Cubs vs Guardians Head to Head

• 4/3/2026: 4-1 CLE (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 7/3/2025: 1-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 7/2/2025: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/1/2025: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/13/2024: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/12/2024: 9-8 CLE (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/30/2023: 10-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

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