Mariners vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 16

Odds updated as of 8:11 p.m.

The MLB slate on Thursday includes the Seattle Mariners facing the San Diego Padres.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Mariners vs Padres Game Info

• Seattle Mariners (8-11) vs. San Diego Padres (12-6)
• Date: Thursday, April 16, 2026
• Time: 8:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: MLB Network, Padres.TV, and Mariners.TV

Mariners vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-122) | SD: (+104)
• Spread: SEA: -1.5 (+138) | SD: +1.5 (-166)
• Total: 8.5 -- Over: (-108) | Under: (-112)

Mariners vs Padres Probable Starting Pitchers

Probable Pitchers: Luis Castillo (Mariners) - 0-0, 6.92 ERA vs Walker Buehler (Padres) - 0-1, 4.97 ERA

The probable starters are Luis Castillo for the Mariners and Walker Buehler (0-1) for the Padres. Castillo and his team are 1-2-0 ATS this season when he starts. Castillo's team is 1-1 this season when he starts and they're favored on the moneyline. The Padres covered all of the three games Buehler started that had a spread set by oddsmakers. The Padres were named the moneyline underdog for one Buehler start this season -- they won.

Mariners vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (54.3%)

Mariners vs Padres Moneyline

• Seattle is a -122 favorite on the moneyline, while San Diego is a +104 underdog at home.

Mariners vs Padres Spread

• The Padres are +1.5 on the run line against the Mariners. The Padres are -166 to cover, and the Mariners are +138.

Mariners vs Padres Over/Under

• The over/under for Mariners-Padres on April 16 is 8.5. The over is -108, and the under is -112.

Bet on Seattle Mariners vs. San Diego Padres on FanDuel today!

Mariners vs Padres Betting Trends

• The Mariners have come away with seven wins in the 15 contests they have been listed as the favorites in this season.
• This season Seattle has come away with a win seven times in 12 chances when named as a favorite of at least -122 on the moneyline.
• The Mariners and their opponents have gone over the total this season in nine of their 19 opportunities.
• The Mariners have an against the spread mark of 7-12-0 in 19 games with a line this season.
• The Padres have been the underdog on the moneyline eight total times this season. They've finished 4-4 in those games.
• San Diego has a record of 3-4 in games it has played as a moneyline underdog with odds of +104 or longer (42.9%).
• The Padres have combined with opponents to go over the total nine times this season for a 9-8-1 record against the over/under.
• The Padres have a 13-5-0 record ATS this season (covering 72.2% of the time).

Mariners Player Leaders

• Randy Arozarena leads Seattle in slugging percentage (.403) thanks to five extra-base hits. He has a .299 batting average and an on-base percentage of .420.
• He is 35th in batting average, 11th in on-base percentage, and 84th in slugging among all qualified hitters in MLB.
• Arozarena has recorded a base hit in two straight games. In his last five games he is batting .368 with a double, three walks and an RBI.
• Luke Raley has 20 hits to go with a slugging percentage of .644, both of which are best among Seattle hitters this season. He's batting .339 with an on-base percentage of .391.
• Among all qualifying batters, he is fifth in batting average, 23rd in on-base percentage and seventh in slugging percentage.
• Raley brings a four-game streak with at least one hit into this one. In his last five games he is hitting .524 with two doubles, a triple, a home run, a walk and five RBIs.
• Brendan Donovan leads Seattle in OBP (.431) this season, fueled by 15 hits.
• Cole Young has two home runs, nine RBI and a batting average of .215 this season.

Padres Player Leaders

• Jackson Merrill is batting .261 with five doubles, three home runs and six walks. He's slugging .464 with an on-base percentage of .320.
• He ranks 73rd in batting average, 107th in on-base percentage and 55th in slugging percentage among all qualified hitters in the big leagues.
• Merrill takes a five-game hitting streak into this matchup. During his last five outings he is batting .450 with three doubles, a home run, a walk and six RBIs.
• Ramon Laureano has 19 hits while slugging .569. Both are team-highs. He has a batting average of .292 with an on-base percentage of .352.
• He is currently 39th in batting average, 64th in on-base percentage and 16th in slugging percentage among all qualifying hitters.
• Xander Bogaerts has a .448 slugging percentage, which paces the Padres.
• Manny Machado's .361 OBP leads his team.

Mariners vs Padres Head to Head

• 4/15/2026: 7-6 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/14/2026: 4-1 SD (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/27/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/26/2025: 7-6 SD (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/25/2025: 9-6 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/18/2025: 6-1 SEA (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/17/2025: 4-1 SEA (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 5/16/2025: 5-1 SEA (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 9/11/2024: 5-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 6.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/10/2024: 7-3 SD (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -126, Underdog Moneyline: +108)

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