Louisville vs Virginia College Basketball Prediction, Odds, Picks, Best Bets for Jan. 13

The Virginia Cavaliers (14-2, 3-1 ACC) will attempt to extend a three-game win streak when they visit the Louisville Cardinals (12-4, 2-2 ACC) on January 13, 2026 at KFC Yum! Center.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Virginia Game Info and Odds

• Game day: Tuesday, January 13, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN2
• Location: Louisville, Kentucky
• Arena: KFC Yum! Center

Louisville vs. Virginia Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Louisville win (62.4%)

If you plan to place a wager on Louisville-Virginia contest (in which Louisville is a 3.5-point favorite and the over/under has been set at 154.5 points), here are some betting trends and insights for Tuesday's game.

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Louisville vs. Virginia: ATS Betting Stats and Trends

• Louisville has covered nine times in 16 chances against the spread this season.
• Virginia is 10-6-0 ATS this year.
• Virginia covers the spread when it is a 3.5-point underdog or more 100% of the time. That's more often than Louisville covers as a favorite of 3.5 or more (69.2%).
• The Cardinals have covered the spread in a higher percentage of their home games than road games. They have covered six times in 10 opportunities at home, and they've covered one time in four opportunities on the road.
• The Cavaliers' winning percentage against the spread at home was .412 (7-10-0) last season. Away, it was .455 (5-6-0).
• Louisville has posted one win against the spread in conference play this season.
• Virginia has beaten the spread three times in four ACC games.

Louisville vs. Virginia: Moneyline Betting Stats

• Louisville has been chosen as the moneyline favorite in eight games this year and has walked away with the win six times (75%) in those games.
• The Cardinals have a win-loss record of 5-1 when favored by -192 or better by bookmakers this year.
• Virginia has been the moneyline underdog just two other times so far this season, and it won both games.
• The Cavaliers have played as a moneyline underdog of +158 or longer in just one game this season, which they won.
• The moneyline set for this matchup implies Louisville has a 65.8% chance of walking away with the win.

Louisville vs. Virginia Head-to-Head Comparison

• Louisville was 65th in college basketball in points scored (78.5 per game) and 89th in points conceded (69.5) last year.
• Last year, Louisville was 47th in the nation in rebounds (34.6 per game) and 114th in rebounds conceded (30.2).
• Louisville was 148th in college basketball in assists (13.9 per game) last season.
• Louisville committed 10.9 turnovers per game last year and forced 12.2 per game, ranking 150th and 93rd, respectively, in college basketball.
• Virginia found it difficult to generate points last season, ranking fifth-worst in college basketball with 64.8 points per game. It fared better at the other end, ranking 39th by giving up 66.8 points per contest.
• Virginia pulled down only 26.8 rebounds per game (worst in college basketball), and allowed 30.1 boards per contest (104th-ranked).
• Virginia ranked 93rd in the nation with 14.7 dimes per contest.
• Virginia ranked 25th-best in college basketball with 9.3 turnovers per game. On the other hand, it ranked 19th-worst in college basketball with 9.2 forced turnovers per contest.

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