Louisville vs Clemson Prediction, Odds, Picks, Best Bets for Week 12 2025

The Louisville Cardinals are among the college football teams in action on Friday, versus the Clemson Tigers.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Louisville vs Clemson Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-130) | Clemson: (+110)
• Spread: Louisville: -2.5 (-112) | Clemson: +2.5 (-108)
• Total: 50.5 -- Over: (-115) | Under: (-105)

Louisville vs Clemson Betting Trends

• Against the spread, Louisville is 3-6-0 this season.
• As at least a 2.5-point favorite, Louisville has two wins ATS (2-6).
• Louisville has played nine games this year, and five of them have hit the over.
• Clemson is 3-6-0 against the spread this season.
• Clemson has seen four of its nine games go over the point total.

Louisville vs Clemson Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (66.8%)

Louisville vs Clemson Point Spread

Louisville is a 2.5-point favorite against Clemson. Louisville is -112 to cover the spread, and Clemson is -108.

Louisville vs Clemson Over/Under

The over/under for the Louisville versus Clemson matchup on Nov. 14 has been set at 50.5, with -115 odds on the over and -105 odds on the under.

Louisville vs Clemson Moneyline

Looking at the moneyline for Louisville-Clemson, Louisville is the favorite at -130, and Clemson is +110.

Louisville vs. Clemson Points Insights

Louisville vs. Clemson Game Info

• Game day: Friday, November 14, 2025
• Game time: 7:30 p.m. ET
• TV channel: ESPN
• Location: Louisville, Kentucky
• Stadium: L&N Federal Credit Union Stadium

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Check out even more in-depth Louisville vs. Clemson analysis on FanDuel Research.