Louisville vs Boston College Prediction, Odds, Picks, Best Bets for Week 9 2025

Saturday's slate in college football includes a matchup between the Louisville Cardinals and the Boston College Eagles.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Louisville vs Boston College Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-4000) | Boston College: (+1500)
• Spread: Louisville: -25.5 (-110) | Boston College: +25.5 (-110)
• Total: 55.5 -- Over: (-104) | Under: (-118)

Louisville vs Boston College Betting Trends

• Louisville has posted two wins against the spread this year.
• Louisville has yet to win ATS (0-2) when playing as at least 25.5-point favorites this season.
• Out of six Louisville games so far this season, three have gone over the total.
• Boston College has won twice against the spread this year.
• Of seven Boston College games so far this season, five have gone over the total.

Louisville vs Boston College Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (93.3%)

Louisville vs Boston College Point Spread

Louisville is favored by 25.5 points over Boston College. Louisville is -110 to cover the spread, with Boston College being -110.

Louisville vs Boston College Over/Under

Louisville versus Boston College on Oct. 25 has an over/under of 55.5 points, with the over -104 and the under -118.

Louisville vs Boston College Moneyline

Boston College is the underdog, +1500 on the moneyline, while Louisville is a -4000 favorite.

Louisville vs. Boston College Points Insights

Louisville vs. Boston College Game Info

• Game day: Saturday, October 25, 2025
• Game time: 7:30 p.m. ET
• TV channel: ACC Network
• Location: Louisville, Kentucky
• Stadium: L&N Federal Credit Union Stadium

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