Louisville vs Boston College Prediction, Odds, Picks, Best Bets for Week 9 2025

College football's Saturday slate includes the Louisville Cardinals facing the Boston College Eagles.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Louisville vs Boston College Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-4000) | Boston College: (+1500)
• Spread: Louisville: -25.5 (-110) | Boston College: +25.5 (-110)
• Total: 54.5 -- Over: (-110) | Under: (-110)

Louisville vs Boston College Betting Trends

• Louisville has posted two wins against the spread this year.
• Louisville has no wins ATS (0-2) as a 25.5-point favorite or greater this season.
• This season, three of Louisville's six games have hit the over.
• Boston College has won twice against the spread this season.
• Boston College has played seven games this season, and five of them have gone over the total.

Louisville vs Boston College Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (93.4%)

Louisville vs Boston College Point Spread

Boston College is a 25.5-point underdog against Louisville. Boston College is -110 to cover the spread, and Louisville is -110.

Louisville vs Boston College Over/Under

The Louisville-Boston College matchup on Oct. 25 has been given an over/under of 54.5 points. The over is -110 and the under is -110.

Louisville vs Boston College Moneyline

Looking at the moneyline for Boston College-Louisville, Boston College is the underdog at +1500, and Louisville is -4000.

Louisville vs. Boston College Points Insights

Louisville vs. Boston College Game Info

• Game day: Saturday, October 25, 2025
• Game time: 7:30 p.m. ET
• TV channel: ACC Network
• Location: Louisville, Kentucky
• Stadium: L&N Federal Credit Union Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Louisville vs. Boston College analysis on FanDuel Research.