Kyler Murray Fantasy Football Week 3: Stats and Projections vs. 49ers

Kyler Murray and the Arizona Cardinals will face the San Francisco 49ers and their sixth-ranked pass defense (166 yards allowed per game) in Week 3, on Sunday at 4:25 p.m. ET.

For more information on Murray, if you're thinking about him for your daily fantasy lineup, check out this article prior to his upcoming matchup versus the 49ers.

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Kyler Murray Week 3 Fantasy Football Projection

• Matchup: Arizona Cardinals at San Francisco 49ers
• Game Date: September 21, 2025
• Game Time: 4:25 p.m.
• Projected Fantasy Points: 16.4
• Projected Passing Yards: 218.62
• Projected Passing TDs: 1.19
• Projected Rushing Yards: 30.26
• Projected Rushing TDs: 0.29

Projections provided by numberFire

Murray Fantasy Performance

• With 32.3 fantasy points in 2025 (16.2 per game), Murray is the 18th-ranked fantasy player at his position and 28th overall.
• Through two games this season, Murray has connected on 38-of-54 passes for 383 yards, with three passing touchdowns and one interception, resulting in 32.3 fantasy points. With his legs, he's added 70 rushing yards on 14 attempts.
• Last week against the Carolina Panthers, Murray posted 14.0 fantasy points, amassing 220 passing yards with one touchdown and one pick while chipping in 32 rushing yards with his legs.

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49ers Defensive Performance

• San Francisco is yet to allow someone to record more than 300 yards passing in a game this season.
• A total of One player has thrown for at least one TD against the 49ers this year.
• San Francisco has allowed one player to throw for two or more TDs in a game this season.
• The 49ers have given up three or more passing touchdowns to one opposing QB this season.
• A total of one player has put up more than 100 yards receiving in a game versus San Francisco this year.
• The 49ers have allowed three players to catch a TD pass against them this season.
• San Francisco has not allowed more than one touchdown catch to an opposing player this year.
• The 49ers have not given up more than 100 yards on the ground to an opposing player this year.
• A total of one player has run for at least one touchdown against San Francisco this season.
• The 49ers have not allowed an opposing player to score more than one rushing TD versus them this year.

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