Iowa State vs Tennessee College Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Sweet 16

The No. 6-seed Tennessee Volunteers (24-11) head into a Sweet 16 matchup against the No. 2 Iowa State Cyclones (29-7) on Friday at 10:25 p.m. ET as the NCAA Tournament continues at United Center airing on TBS.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Tennessee Game Info and Odds

• Game day: Friday, March 27, 2026
• Game time: 10:25 p.m. ET
• TV channel: TBS
• Location: Chicago, Illinois
• Arena: United Center

Iowa State vs. Tennessee Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (58.8%)

Before making a wager on Friday's Iowa State-Tennessee spread (Iowa State -3.5) or total (139.5 points), read the betting insights and trends below.

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Iowa State vs. Tennessee: ATS Betting Stats and Trends

• Iowa State has covered 22 times in 36 matchups with a spread this season.
• Tennessee has compiled a 17-18-0 ATS record so far this season.
• When the spread is set as 3.5 or more this season, Iowa State (19-11) covers a lower percentage of those games when it is the favorite (63.3%) than Tennessee (3-1) does as the underdog (75%).
• Against the spread, the Cyclones have fared better when playing at home, covering nine times in 17 home games, and five times in 10 road games.
• Against the spread, the Volunteers have performed better at home (8-9-0) than on the road (4-6-0).

Iowa State vs. Tennessee: Moneyline Betting Stats

• Iowa State has been victorious in 24, or 82.8%, of the 29 contests it has been chosen as moneyline favorites in this season.
• The Cyclones have a win-loss record of 22-4 when favored by -178 or better by bookmakers this year.
• Tennessee has gone 3-3 in games it was listed as the moneyline underdog (winning 50% of those games).
• The Volunteers have played as a moneyline underdog of +146 or longer in just two games this season, which they split 1-1.
• The moneyline set for this matchup implies Iowa State has a 64% chance of coming away with a victory in the contest.

Iowa State vs. Tennessee Head-to-Head Comparison

• Iowa State has a +619 scoring differential, topping opponents by 17.2 points per game. It is putting up 82.5 points per game to rank 45th in college basketball and is giving up 65.3 per outing to rank 12th in college basketball.
• Milan Momcilovic ranks 139th in the nation with a team-leading 17.2 points per game.
• Tennessee puts up 79.4 points per game (92nd in college basketball) while giving up 69.1 per outing (56th in college basketball). It has a +362 scoring differential and outscores opponents by 10.3 points per game.
• Ja'Kobi Gillespie's team-leading 18.4 points per game rank him 76th in the nation.
• The Cyclones win the rebound battle by 3.9 boards on average. They record 32.3 rebounds per game, which ranks 152nd in college basketball, while their opponents grab 28.4 per outing.
• Joshua Jefferson's 7.4 rebounds per game lead the Cyclones and rank 110th in college basketball play.
• The 39.2 rebounds per game the Volunteers accumulate rank third in the country, 13.1 more than the 26.1 their opponents record.
• Nate Ament tops the Volunteers with 6.4 rebounds per game (231st in college basketball).
• Iowa State ranks 17th in college basketball with 107 points scored per 100 possessions, and seventh in college basketball defensively with 84.7 points conceded per 100 possessions.
• The Volunteers rank 94th in college basketball with 100.8 points scored per 100 possessions, and 31st defensively with 87.7 points conceded per 100 possessions.

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