Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for April 30

Odds updated as of 6:11 p.m.

The Wednesday schedule in MLB includes a matchup between the Cleveland Guardians and the Minnesota Twins.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Guardians vs Twins Game Info

• Cleveland Guardians (16-13) vs. Minnesota Twins (13-17)
• Date: Wednesday, April 30, 2025
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and MNNT

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-130) | MIN: (+110)
• Spread: CLE: -1.5 (+158) | MIN: +1.5 (-192)
• Total: 8 -- Over: (-105) | Under: (-115)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Luis Ortiz (Guardians) - 2-3, 5.96 ERA vs Pablo Lopez (Twins) - 2-1, 2.08 ERA

This contest's pitching matchup is set, as the Guardians will send Luis Ortiz (2-3) to the mound, while Pablo Lopez (2-1) will get the nod for the Twins. Ortiz and his team have a record of 2-3-0 against the spread when he starts. Ortiz's team has won 66.7% of his starts when they are favored on the moneyline (2-1). The Twins have gone 3-1-0 ATS in Lopez's four starts with a set spread. The Twins were named the moneyline underdog for one Lopez start this season -- they lost.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (52.3%)

Guardians vs Twins Moneyline

• Minnesota is a +110 underdog on the moneyline, while Cleveland is a -130 favorite at home.

Guardians vs Twins Spread

• The Guardians are hosting the Twins and are favored by 1.5 runs on the spread. The Guardians are +158 to cover the runline, with the Twins being -192.

Guardians vs Twins Over/Under

• A combined run total of 8 has been set for Guardians-Twins on April 30, with the over at -105 and the under at -115.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have won in eight, or 72.7%, of the 11 contests they have been named as odds-on favorites in this year.
• This season Cleveland has been victorious five times in six chances when named as a favorite of at least -130 on the moneyline.
• The Guardians and their opponents have gone over the total this season in 16 of their 28 opportunities.
• In 28 games with a line this season, the Guardians have a mark of 12-16-0 against the spread.
• The Twins have compiled a 1-6 record in games they were listed as the moneyline underdog (winning 14.3% of those games).
• Minnesota has played as a moneyline underdog of +110 or longer in only two games this season, which it lost both.
• The Twins have played in 29 games with a set over/under, and have combined with their opponents to go over the total 11 times (11-15-3).
• The Twins have a 15-14-0 record ATS this season (covering 51.7% of the time).

Guardians Player Leaders

• Steven Kwan has an OPS of .865, fueled by an OBP of .382 to go with a slugging percentage of .482. He has a .333 batting average, as well.
• Among qualified hitters in baseball, he ranks seventh in batting average, 27th in on-base percentage, and 42nd in slugging.
• Jose Ramirez has four doubles, five home runs and nine walks. He's batting .255 and slugging .441 with an on-base percentage of .310.
• He is 72nd in batting average, 97th in on-base percentage and 57th in slugging in the major leagues.
• Kyle Manzardo leads Cleveland in total hits (20) this season, and 12 of those have gone for extra bases.
• Manzardo has picked up a hit in three straight games. In his last five games he is hitting .263 with a double, a home run, a walk and two RBI.
• Gabriel Arias has four home runs, 11 RBI and a batting average of .270 this season.
• Arias enters this game on a five-game hitting streak. During his last five outings he is batting .263 with three doubles and an RBI.

Twins Player Leaders

• Ty France has racked up an on-base percentage of .345 and a slugging percentage of .410. Both lead the Twins. He's batting .267.
• Including all qualifying hitters in MLB, his batting average places him 62nd, his on-base percentage ranks 59th, and he is 81st in slugging.
• France hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .421 with three doubles, a home run, a walk and six RBI.
• Byron Buxton's 25 hits pace his team. He has a batting average of .238 while slugging .486 with an on-base percentage of .274.
• Including all qualifying hitters, he ranks 97th in batting average, 136th in on-base percentage and 38th in slugging percentage.
• Trevor Larnach is hitting .223 with two doubles, four home runs and 13 walks.
• Ryan Jeffers is batting .257 with seven doubles, a home run and nine walks.

Guardians vs Twins Head to Head

• 4/28/2025: 11-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/19/2024: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/18/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/17/2024: 4-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/16/2024: 4-3 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2024: 5-3 CLE (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/9/2024: 6-3 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/9/2024: 4-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/19/2024: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/18/2024: 11-4 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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