Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for April 28

Odds updated as of 5:12 p.m.

In MLB action on Monday, the Cleveland Guardians take on the Minnesota Twins.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Twins Game Info

• Cleveland Guardians (15-12) vs. Minnesota Twins (12-16)
• Date: Monday, April 28, 2025
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and MNNT

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-132) | MIN: (+112)
• Spread: CLE: -1.5 (+158) | MIN: +1.5 (-192)
• Total: 8 -- Over: (-115) | Under: (-105)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 2-1, 4.15 ERA vs Bailey Ober (Twins) - 2-1, 5.04 ERA

The Guardians will give the nod to Gavin Williams (2-1, 4.15 ERA), who is eyeing win No. 3 on the season, and the Twins will counter with Bailey Ober (2-1, 5.04 ERA). Williams and his team are 3-2-0 ATS this season when he starts. Williams' team is 2-0 this season when he starts and they're favored on the moneyline. The Twins have a 3-2-0 ATS record in Ober's five starts that had a set spread. The Twins were named the moneyline underdog for one Ober start this season -- they lost.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (54.7%)

Guardians vs Twins Moneyline

• Looking at the moneyline for Twins-Guardians, Minnesota is the underdog at +112, and Cleveland is -132 playing at home.

Guardians vs Twins Spread

• The Twins are at the Guardians, and are +1.5 on the runline. The Twins are +158 to cover the spread, and the Guardians are -192.

Guardians vs Twins Over/Under

• The over/under for Guardians-Twins on April 28 is 8. The over is -115, and the under is -105.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have been chosen as favorites in 10 games this year and have walked away with the win eight times (80%) in those games.
• Cleveland has a record of 4-1 when favored by -132 or more this year.
• The Guardians and their opponents have gone over in 15 of their 27 games with a total set by sportsbooks this season.
• The Guardians have posted a record of 12-15-0 against the spread this season.
• The Twins have lost all six of the games they have been the moneyline underdog this season.
• Minnesota has played as a moneyline underdog of +112 or longer in just two games this season, which it lost both.
• The Twins have played in 28 games with an over/under set, and have combined with their opponents to go over the total 10 times (10-15-3).
• The Twins have put together a 14-14-0 record against the spread this season (covering 50% of the time).

Guardians Player Leaders

• Steven Kwan leads Cleveland OPS (.901) this season. He has a .346 batting average, an on-base percentage of .397, and a slugging percentage of .505.
• Among qualified batters, he is fourth in batting average, his on-base percentage ranks 15th, and he is 31st in slugging.
• Kwan has recorded at least one hit in 10 straight games. During his last 10 outings he is hitting .400 with four doubles, a home run, three walks and four RBI.
• Jose Ramirez is batting .263 with four doubles, five home runs and nine walks, while slugging .463 with an on-base percentage of .321.
• He is 59th in batting average, 84th in on-base percentage and 47th in slugging in MLB.
• Kyle Manzardo leads Cleveland with 17 hits. He is batting .210 this season and 11 of his hits have gone for extra bases.
• Gabriel Arias has been key for Cleveland with 22 hits, an OBP of .318 plus a slugging percentage of .481.
• Arias has hit safely in three games in a row. During his last five outings he is batting .250 with two doubles and an RBI.

Twins Player Leaders

• Byron Keiron Buxton has accumulated a slugging percentage of .505 and has 23 hits, both team-best marks for the Twins. He's batting .237 and with an on-base percentage of .269.
• Including all the qualifying players in the majors, he is 95th in batting average, 137th in on-base percentage and 31st in slugging percentage.
• Trevor Larnach's .330 OBP leads his team. He has a batting average of .234 while slugging .383.
• His batting average is 100th among all qualified players, his on-base percentage ranks 72nd, and he is 96th in slugging.
• Ty France has a slugging percentage of .351, a team-high for the Twins.
• Carlos Javier Correa is batting .211 with seven doubles, a home run and seven walks.

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