Guardians vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 8:11 a.m.

The MLB's Friday schedule includes the Cleveland Guardians facing the Cincinnati Reds.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Reds Game Info

• Cleveland Guardians (25-18) vs. Cincinnati Reds (21-24)
• Date: Friday, May 16, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and CLEG

Guardians vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-126) | CIN: (+108)
• Spread: CLE: -1.5 (+122) | CIN: +1.5 (-146)
• Total: 9 -- Over: (-106) | Under: (-114)

Guardians vs Reds Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 3-3, 3.80 ERA vs Brady Singer (Reds) - 4-2, 4.97 ERA

The Guardians will give the nod to Tanner Bibee (3-3, 3.80 ERA), who is eyeing win No. 4 on the season, and the Reds will counter with Brady Singer (4-2, 4.97 ERA). Bibee and his team are 3-4-0 ATS this season when he starts. When Bibee starts a game and his team is the favorite on the moneyline, they have a record of 3-1. The Reds are 5-3-0 ATS in Singer's eight starts with a set spread. The Reds have been the moneyline underdog in four of Singer's starts this season, and they went 3-1 in those games.

Guardians vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (55.7%)

Guardians vs Reds Moneyline

• Cincinnati is the underdog, +108 on the moneyline, while Cleveland is a -126 favorite despite being on the road.

Guardians vs Reds Spread

• The Guardians are at the Reds and are favored by 1.5 runs (+122 to cover) on the runline. Cincinnati is -146 to cover.

Guardians vs Reds Over/Under

• The Guardians-Reds game on May 16 has been given an over/under of 9 runs. The over is set at -106 and the under at -114.

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Guardians vs Reds Betting Trends

• The Guardians have won in 11, or 68.8%, of the 16 contests they have been named as odds-on favorites in this year.
• This season Cleveland has been victorious six times in seven chances when named as a favorite of at least -126 on the moneyline.
• The Guardians and their opponents have hit the over in 22 of their 42 games with a total set by oddsmakers this season.
• The Guardians have posted a record of 20-22-0 against the spread this season.
• The Reds have gone 10-14 in games they were the underdog on the moneyline (winning 41.7% of those games).
• Cincinnati has a 5-8 record (winning only 38.5% of its games) when playing as a moneyline underdog of +108 or longer.
• The Reds have had an over/under set by bookmakers 43 times, and have combined with opponents to go over the total in 18 of those games (18-24-1).
• The Reds have a 22-21-0 record against the spread this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 44 hits, batting .295 this season with 16 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .510.
• He is 23rd in batting average, 43rd in on-base percentage, and 23rd in slugging among qualified batters in baseball.
• Ramirez hopes to build on a nine-game hitting streak in this matchup. During his last 10 outings he is hitting .361 with three doubles, three home runs, seven walks and seven RBIs.
• Steven Kwan leads the Guardians with an OPS of .833. He has a slash line of .325/.384/.450 this season.
• Among qualified hitters, his batting average places him sixth, his on-base percentage 20th, and his slugging percentage 61st.
• Kyle Manzardo is batting .221 with a .504 slugging percentage and 25 RBI this year.
• Manzardo heads into this game with three games in a row with at least one hit. In his last five games he is batting .222 with a triple, a home run and three RBIs.
• Carlos Santana has four home runs, 19 RBI and a batting average of .220 this season.

Reds Player Leaders

• Elly De La Cruz has a slugging percentage of .426 and has 45 hits, both team-best marks for the Reds. He's batting .256 and with an on-base percentage of .327.
• Including all qualified hitters in the majors, he is 78th in batting average, 87th in on-base percentage and 74th in slugging percentage.
• De La Cruz hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .286 with a double, three home runs and six RBIs.
• TJ Friedl is hitting .274 with six doubles, a triple, three home runs and 20 walks. He's slugging .382 with an on-base percentage of .359.
• Including all qualified hitters, he is 52nd in batting average, 47th in on-base percentage and 108th in slugging percentage.
• Gavin Lux has put up a team-high .383 on-base percentage.
• Matt McLain is hitting .182 with three doubles, six home runs and 21 walks.

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