Guardians vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 5:14 p.m.

The Friday slate in MLB includes a matchup between the Cleveland Guardians and the Cincinnati Reds.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Reds Game Info

• Cleveland Guardians (25-18) vs. Cincinnati Reds (21-24)
• Date: Friday, May 16, 2025
• Time: 5:10 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and CLEG

Guardians vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | CIN: (-100)
• Spread: CLE: -1.5 (+130) | CIN: +1.5 (-156)
• Total: 9.5 -- Over: (-100) | Under: (-122)

Guardians vs Reds Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 3-3, 3.80 ERA vs Brady Singer (Reds) - 4-2, 4.97 ERA

This contest's pitching matchup is set, as the Guardians will send Tanner Bibee (3-3) to the mound, while Brady Singer (4-2) will take the ball for the Reds. Bibee and his team have a record of 3-4-0 against the spread when he starts. Bibee's team has won 75% of his starts when they are favored on the moneyline (3-1). The Reds have a 5-3-0 record against the spread in Singer's starts. The Reds are 3-1 in Singer's four starts this season that they were the moneyline underdog.

Guardians vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (55.7%)

Guardians vs Reds Moneyline

• Cincinnati is the underdog, -100 on the moneyline, while Cleveland is a -118 favorite despite being on the road.

Guardians vs Reds Spread

• The Reds are at +1.5 on the runline against the Guardians. The Reds are -156 to cover the spread, and the Guardians are +130.

Guardians vs Reds Over/Under

• An over/under of 9.5 has been set for Guardians-Reds on May 16, with the over being -100 and the under -122.

Bet on Cleveland Guardians vs. Cincinnati Reds on FanDuel today!

Guardians vs Reds Betting Trends

• The Guardians have come away with 11 wins in the 16 contests they have been listed as the favorites in this season.
• This season Cleveland has been victorious eight times in 12 chances when named as a favorite of at least -118 on the moneyline.
• The Guardians' games have gone over the total in 22 of their 42 opportunities.
• The Guardians have an against the spread record of 20-22-0 in 42 games with a line this season.
• The Reds are 10-14 in games they were the underdog on the moneyline (winning 41.7% of those games).
• Cincinnati has a record of 8-11 in games it has played as a moneyline underdog with odds of -100 or longer (42.1%).
• The Reds have combined with opponents to hit the over on the total 18 times this season for an 18-24-1 record against the over/under.
• The Reds are 22-21-0 against the spread this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 44 hits, batting .295 this season with 16 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .510.
• He is 23rd in batting average, 43rd in on-base percentage, and 23rd in slugging among all qualifying hitters in the majors.
• Ramirez hopes to build on a nine-game hitting streak in this matchup. In his last 10 games he is batting .361 with three doubles, three home runs, seven walks and seven RBIs.
• Steven Kwan leads the Guardians with an OPS of .833. He has a slash line of .325/.384/.450 this season.
• He ranks sixth in batting average, 20th in on-base percentage and 61st in slugging in the majors.
• Kyle Manzardo has 29 hits this season and has a slash line of .221/.314/.504.
• Manzardo brings a three-game hitting streak into this matchup. During his last five outings he is hitting .222 with a triple, a home run and three RBIs.
• Carlos Santana is batting .220 with a .331 OBP and 19 RBI for Cleveland this season.

Reds Player Leaders

• Elly De La Cruz has put up a team-best slugging percentage (.426) while leading the Reds in hits (45). He's batting .256 and with an on-base percentage of .327.
• He ranks 78th in batting average, 87th in on-base percentage and 74th in slugging percentage among all qualifying batters in the big leagues.
• De La Cruz takes a three-game hitting streak into this matchup. In his last five games he is hitting .286 with a double, three home runs and six RBIs.
• TJ Friedl is hitting .274 with six doubles, a triple, three home runs and 20 walks. He's slugging .382 with an on-base percentage of .359.
• Including all qualified hitters, he is 53rd in batting average, 47th in on-base percentage and 109th in slugging percentage.
• Gavin Lux has an on-base percentage of .383, a team-best for the Reds.
• Matt McLain is hitting .182 with three doubles, six home runs and 21 walks.

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