Guardians vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for April 27

Odds updated as of 1:11 a.m.

The MLB's Monday slate includes the Cleveland Guardians taking on the Tampa Bay Rays.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Rays Game Info

• Cleveland Guardians (15-14) vs. Tampa Bay Rays (16-11)
• Date: Monday, April 27, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: Fox Sports 1, CleGuardians.TV, and Rays.TV

Guardians vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-144) | TB: (+122)
• Spread: CLE: -1.5 (+150) | TB: +1.5 (-182)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Guardians vs Rays Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 3-0, 1.76 ERA vs Steven Matz (Rays) - 3-1, 4.81 ERA

The probable pitchers are Parker Messick (3-0) for the Guardians and Steven Matz (3-1) for the Rays. Messick and his team have covered in each of the five games he's started with a spread this season. Messick's team is 2-0 this season when he starts and they're favored on the moneyline. The Rays are 4-1-0 against the spread when Matz starts. The Rays were named the moneyline underdog for two Matz starts this season -- they split the games.

Guardians vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50.2%)

Guardians vs Rays Moneyline

• The moneyline numbers for Guardians vs. Rays reveal Cleveland as the favorite (-144) and Tampa Bay as the underdog (+122) on the road.

Guardians vs Rays Spread

• The Guardians are 1.5-run home favorites on the runline against the Rays. The Guardians are +150 to cover, and the Rays are -182.

Guardians vs Rays Over/Under

• An over/under of 7.5 has been set for Guardians-Rays on April 27, with the over being -110 and the under -110.

Bet on Cleveland Guardians vs. Tampa Bay Rays on FanDuel today!

Guardians vs Rays Betting Trends

• The Guardians have been favorites in 12 games this season and have come away with the win seven times (58.3%) in those contests.
• Cleveland has been listed as a favorite of -144 or more on two occasions this season and split those games.
• Contests with the Guardians have gone over the total set by oddsmakers in 15 of 29 chances this season.
• The Guardians have posted a record of 16-13-0 against the spread this season.
• The Rays have won 50% of the games this season they were the moneyline underdog (6-6).
• Tampa Bay has won all four games it has played as a moneyline underdog with odds of +122 or longer.
• The Rays have combined with opponents to go over the total 17 times this season for a 17-10-0 record against the over/under.
• The Rays are 16-11-0 against the spread this season.

Guardians Player Leaders

• Jose Ramirez is batting .229 with six doubles, six home runs and 21 walks. He has an on-base percentage of .357 and a slugging percentage of .457.
• Among all qualified batters in baseball, he ranks 119th in batting average, 49th in on-base percentage, and 56th in slugging.
• Chase DeLauter leads Cleveland with 21 hits. He is batting .233 this season and has 11 extra-base hits. He's also slugging .478 with an on-base percentage of .327.
• Among qualified hitters, he ranks 109th in batting average, 95th in on-base percentage and 39th in slugging percentage.
• DeLauter has picked up a hit in two games in a row. During his last five outings he is hitting .294 with a triple, two walks and four RBIs.
• Brayan Rocchio leads the Guardians with an OPS of .774. He has a slash line of .278/.363/.411 this season.
• Rocchio takes a three-game hitting streak into this game. In his last five games he is hitting .250 with three RBIs.
• Angel Martinez has five home runs, 15 RBI and a batting average of .289 this season.
• Martinez heads into this matchup on a three-game hitting streak. During his last five outings he is batting .389 with a double, three home runs and six RBIs.

Rays Player Leaders

• Yandy Diaz has racked up an on-base percentage of .425 and a slugging percentage of .500. Both lead the Rays. He's batting .337.
• He is fourth in batting average, fourth in on-base percentage and 29th in slugging percentage among all qualified hitters in the majors.
• Diaz heads into this matchup on a five-game hitting streak. In his last five games he is hitting .389 with a home run, a walk and three RBIs.
• Junior Caminero leads his team with 28 hits. He has a batting average of .259 while slugging .509 with an on-base percentage of .336.
• Including all qualifying hitters, he ranks 68th in batting average, 82nd in on-base percentage and 28th in slugging percentage.
• Jonathan Aranda is batting .227 with four doubles, six home runs and 19 walks.
• Chandler Simpson has two triples and six walks while hitting .321.

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