Guardians vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for April 19

Odds updated as of 1:12 p.m.

Sunday's slate in the MLB includes a matchup between the Cleveland Guardians and the Baltimore Orioles.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Orioles Game Info

• Cleveland Guardians (12-10) vs. Baltimore Orioles (10-11)
• Date: Sunday, April 19, 2026
• Time: 1:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and MASN

Guardians vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | BAL: (+100)
• Spread: CLE: +1.5 (-220) | BAL: -1.5 (+180)
• Total: 6.5 -- Over: (-122) | Under: (+100)

Guardians vs Orioles Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 1-0, 2.61 ERA vs Trevor Rogers (Orioles) - 2-1, 3.04 ERA

This contest's pitching matchup is set, as the Guardians will send Joey Cantillo (1-0) to the mound, while Trevor Rogers (2-1) will get the nod for the Orioles. Cantillo and his team are 3-1-0 ATS this season when he starts. Cantillo's team lost his only start as a favorite this season. When Rogers starts, the Orioles have gone 2-2-0 against the spread. The Orioles have not been a moneyline underdog when Rogers starts this season.

Guardians vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.9%)

Guardians vs Orioles Moneyline

• Baltimore is a +100 underdog on the moneyline, while Cleveland is a -118 favorite at home.

Guardians vs Orioles Spread

• The Orioles are 1.5-run favorites against the spread for this matchup with the Guardians. The Orioles are +180 to cover, while the Guardians are -220 to cover as a 1.5-run underdog on the runline.

Guardians vs Orioles Over/Under

• Guardians versus Orioles on April 19 has an over/under of 6.5 runs, with the odds on the over -122 and the under set at +100.

Bet on Cleveland Guardians vs. Baltimore Orioles on FanDuel today!

Guardians vs Orioles Betting Trends

• The Guardians have been chosen as favorites in seven games this year and have walked away with the win four times (57.1%) in those games.
• Cleveland has a record of 4-3 when favored by -118 or more this year.
• The Guardians and their opponents have gone over in 10 of their 22 games with a total set by sportsbooks this season.
• In 22 games with a line this season, the Guardians have a mark of 13-9-0 against the spread.
• The Orioles have won 28.6% of the games this season they were the moneyline underdog (2-5).
• Baltimore has a 2-4 record (winning just 33.3% of its games) when it has played as a moneyline underdog of +100 or longer.
• The Orioles have combined with opponents to hit the over on the total 11 times this season for an 11-10-0 record against the over/under.
• The Orioles have covered only 38.1% of their games this season, going 8-13-0 against the spread.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with an OBP of .347 this season while batting .215 with 16 walks and 12 runs scored. He has a slugging percentage of .418.
• Among all qualifying hitters in baseball, he ranks 134th in batting average, 69th in on-base percentage, and 78th in slugging.
• Chase DeLauter leads Cleveland in total hits (16) this season while batting .232 with 10 extra-base hits. He's slugging .522 with an on-base percentage of .325.
• He ranks 117th in batting average, 102nd in on-base percentage and 28th in slugging in MLB.
• Brayan Rocchio has 14 hits this season and has a slash line of .222/.338/.397.
• Rocchio takes a five-game hitting streak into this matchup. During his last five outings he is batting .375 with a double, two home runs, a walk and five RBIs.
• Steven Kwan leads Cleveland in slugging percentage (.313) thanks to four extra-base hits.

Orioles Player Leaders

• Gunnar Henderson is batting .213 with three doubles, a triple, seven home runs and eight walks. He's slugging .506 with an on-base percentage of .283.
• Including all qualified hitters in the big leagues, he is 139th in batting average, 149th in on-base percentage and 43rd in slugging percentage.
• Taylor Ward has a .388 OBP while slugging .422. Both lead his team. He has a batting average of .289.
• Including all qualified hitters, he ranks 40th in batting average, 26th in on-base percentage and 77th in slugging percentage.
• Jeremiah Jackson paces the Orioles with 19 hits.
• Leody Taveras is batting .368 with three doubles, a home run and nine walks.

Guardians vs Orioles Head to Head

• 4/18/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/17/2026: 6-4 BAL (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 4-3 BAL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/23/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/22/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/21/2025: 10-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/17/2025: 6-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2025: 9-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/15/2025: 6-3 CLE (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

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