Guardians vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for April 13

Odds updated as of 7:11 p.m.

Monday's slate in the MLB includes a matchup between the Cleveland Guardians and the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this game.

Guardians vs Cardinals Game Info

• Cleveland Guardians (9-7) vs. St. Louis Cardinals (8-7)
• Date: Monday, April 13, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and CleGuardians.TV

Guardians vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | STL: (+100)
• Spread: CLE: -1.5 (+140) | STL: +1.5 (-170)
• Total: 8 -- Over: (-115) | Under: (-105)

Guardians vs Cardinals Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 1-1, 2.04 ERA vs Matthew Liberatore (Cardinals) - 0-0, 3.38 ERA

The Guardians will look to Gavin Williams (1-1) against the Cardinals and Matthew Liberatore. Williams and his team are 2-1-0 ATS this season when he starts. Williams' team won his only start as a favorite this season. The Cardinals have a 2-1-0 ATS record in Liberatore's three starts with a set spread. The Cardinals won each of Liberatore's three starts this season that they were the moneyline underdog.

Guardians vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (54.4%)

Guardians vs Cardinals Moneyline

• The Guardians vs Cardinals moneyline has Cleveland as a -118 favorite, while St. Louis is a +100 underdog at home.

Guardians vs Cardinals Spread

• The Guardians are favored by 1.5 runs on the road versus the Cardinals. The Guardians are +140 to cover the spread, while the Cardinals are -170.

Guardians vs Cardinals Over/Under

• The over/under for the Guardians versus Cardinals contest on April 13 has been set at 8, with -115 odds on the over and -105 odds on the under.

Bet on Cleveland Guardians vs. St. Louis Cardinals on FanDuel today!

Guardians vs Cardinals Betting Trends

• The Guardians have split the two match ups they have played as odds-on favorites this season.
• Cleveland has been listed as a favorite of -118 or more on two occasions this season and split those games.
• The Guardians' games have gone over the total in seven of their 16 opportunities.
• The Guardians are 10-6-0 against the spread in their 16 games with a line set by sportsbooks this season.
• The Cardinals have won seven of the 13 games they were listed as the moneyline underdog this season (53.8%).
• St. Louis has a 5-4 record (winning 55.6% of its games) when playing as a moneyline underdog of +100 or longer.
• The Cardinals have played in 15 games with a set over/under, and have combined with their opponents to go over the total eight times (8-6-1).
• The Cardinals have covered 46.7% of their games this season, going 7-8-0 against the spread.

Guardians Player Leaders

• Chase DeLauter has 15 hits and an OBP of .379 to go with a slugging percentage of .680. All three of those stats rank first among Cleveland hitters this season. He has a .300 batting average, as well.
• He ranks 39th in batting average, 37th in on-base percentage, and fifth in slugging among qualified hitters in baseball.
• DeLauter has recorded at least one hit in four games in a row. During his last five outings he is hitting .333 with four doubles, four walks and three RBIs.
• Jose Ramirez is hitting .180 with three doubles, two home runs and eight walks. He's slugging .328 with an on-base percentage of .275.
• Among qualified hitters, his batting average places him 154th, his on-base percentage 147th, and his slugging percentage 117th.
• Ramirez enters this game looking to extend his two-game hit streak. During his last five outings he is hitting .250 with a double, a home run, three walks and two RBIs.
• Angel Martinez has collected 13 base hits, an OBP of .383 and a slugging percentage of .452 this season.
• Steven Kwan is batting .246 with a .338 OBP and four RBI for Cleveland this season.

Cardinals Player Leaders

• Jordan Walker has accumulated an on-base percentage of .393, a slugging percentage of .745, and has 18 hits, all club-bests for the Cardinals (while batting .327).
• Including all the qualified hitters in the majors, his batting average ranks 14th, his on-base percentage ranks 29th, and he is second in slugging.
• Walker hopes to build on an eight-game hitting streak in this matchup. In his last 10 outings he is batting .342 with six home runs, three walks and 11 RBIs.
• Alec Burleson is batting .259 with two doubles, two home runs and 11 walks. He's slugging .407 with an on-base percentage of .379.
• Including all qualifying hitters, his batting average puts him 69th, his on-base percentage ranks 37th, and he is 79th in slugging.
• JJ Wetherholt is hitting .214 with a double, a home run and 10 walks.
• Ivan Herrera has three doubles and 14 walks while batting .192.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!