Guardians vs Blue Jays Prediction, Odds, Moneyline, Spread & Over/Under for June 25

Odds updated as of 6:11 p.m.

The Cleveland Guardians versus the Toronto Blue Jays is on the MLB schedule for Wednesday.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Blue Jays Game Info

• Cleveland Guardians (39-38) vs. Toronto Blue Jays (42-36)
• Date: Wednesday, June 25, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and SNET

Guardians vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-120) | TOR: (+102)
• Spread: CLE: -1.5 (+164) | TOR: +1.5 (-200)
• Total: 8.5 -- Over: (-100) | Under: (-122)

Guardians vs Blue Jays Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 5-3, 3.58 ERA vs Max Scherzer (Blue Jays) - 0-0, 6.00 ERA

The Guardians will call on Gavin Williams (5-3) versus the Blue Jays and Max Scherzer. Williams and his team have a record of 8-7-0 against the spread when he starts. When Williams starts a game and his team is the favorite on the moneyline, they have a record of 3-2. Scherzer has started just one game with a set spread, which the Blue Jays failed to cover. The Blue Jays have not been a moneyline underdog when Scherzer starts this season.

Guardians vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (52.4%)

Guardians vs Blue Jays Moneyline

• Cleveland is the favorite, -120 on the moneyline, while Toronto is a +102 underdog on the road.

Guardians vs Blue Jays Spread

• The Blue Jays are at the Guardians, and are +1.5 on the runline. The Blue Jays are +164 to cover the spread, and the Guardians are -200.

Guardians vs Blue Jays Over/Under

• A combined run total of 8.5 has been set for Guardians-Blue Jays on June 25, with the over at -100 and the under at -122.

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Guardians vs Blue Jays Betting Trends

• The Guardians have been chosen as favorites in 26 games this year and have walked away with the win 16 times (61.5%) in those games.
• Cleveland has a record of 12-6 when favored by -120 or more this year.
• The Guardians and their opponents have hit the over in 32 of their 75 games with a total set by oddsmakers this season.
• The Guardians are 38-37-0 against the spread in their 75 games with a line set by sportsbooks this season.
• The Blue Jays have won 50% of the games this season they were the moneyline underdog (23-23).
• Toronto is 16-14 (winning 53.3% of its games) when it has played as a moneyline underdog of +102 or longer.
• In the 77 games oddsmakers have set an over/under for the Blue Jays, they have combined with opponents to go over the total 41 times (41-33-3).
• The Blue Jays have a 46-31-0 record against the spread this season (covering 59.7% of the time).

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 90 hits and an OBP of .377, plus a team-best slugging percentage of .518. He's batting .317.
• Among the qualified hitters in the majors, his batting average ranks seventh, his on-base percentage ranks 19th, and he is 16th in slugging.
• Steven Kwan has 17 doubles, six home runs and 26 walks. He's batting .310 and slugging .432 with an on-base percentage of .371.
• Among qualifying hitters, he ranks ninth in batting average, 24th in on-base percentage and 71st in slugging percentage.
• Kwan heads into this game looking to extend his five-game hit streak. During his last five outings he is batting .524 with three doubles, a walk and an RBI.
• Carlos Santana has collected 61 base hits, an OBP of .333 and a slugging percentage of .370 this season.
• Kyle Manzardo has been key for Cleveland with 49 hits, an OBP of .298 plus a slugging percentage of .448.
• Manzardo brings a three-game hitting streak into this game. In his last five games he is batting .400 with three doubles, a home run, a walk and an RBI.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has a team-best .383 on-base percentage. He's batting .281 and slugging .441.
• He is 39th in batting average, 15th in on-base percentage and 64th in slugging percentage among all qualifying hitters in the big leagues.
• Bo Bichette is slugging .440 to pace his team. He has a batting average of .277 with an on-base percentage of .318.
• He is 48th in batting average, 101st in on-base percentage and 66th in slugging percentage in the big leagues.
• George Springer has collected 61 hits, a team-high for the Blue Jays.
• Alejandro Kirk has eight doubles, seven home runs and 16 walks while batting .309.

Guardians vs Blue Jays Head to Head

• 6/24/2025: 10-6 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/4/2025: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/3/2025: 5-3 CLE (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/2/2025: 5-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/23/2024: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/22/2024: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/21/2024: 7-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/16/2024: 7-6 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/15/2024: 5-0 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/14/2024: 3-1 CLE (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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