Guardians vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 18

Odds updated as of 6:11 p.m.

On Friday in MLB, the Cleveland Guardians are playing the Athletics.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Guardians vs Athletics Game Info

• Cleveland Guardians (78-75) vs. Athletics (61-92)
• Date: Friday, September 18, 2026
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and NBCS-CA

Guardians vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-230) | OAK: (+190)
• Spread: CLE: -1.5 (+102) | OAK: +1.5 (-122)
• Total: 8.5 -- Over: (-104) | Under: (-118)

Guardians vs Athletics Probable Starting Pitchers

Probable Pitchers: Daniel Espino (Guardians) - 0-0, 2.92 ERA vs Mason Barnett (Athletics) - 1-4, 7.08 ERA

The Guardians will give the ball to Daniel Espino and the Athletics will counter with Mason Barnett (1-4, 7.08 ERA). Espino and his team failed to cover the spread in his only opportunity this season as a starter. Espino has yet to start a game this season when his team was the moneyline favorite. The Athletics are 2-2-0 ATS in Barnett's four starts with a set spread. The Athletics were the underdog on the moneyline for four Barnett starts this season -- they lost every time.

Guardians vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (58.5%)

Guardians vs Athletics Moneyline

• The Guardians vs Athletics moneyline has the Guardians as a -230 favorite, while the Athletics are a +190 underdog on the road.

Guardians vs Athletics Spread

• The Guardians are 1.5-run favorites on the runline against the Athletics. The Guardians are +102 to cover, while the Athletics are -122 to cover.

Guardians vs Athletics Over/Under

• A total of 8.5 runs has been set for the Guardians-Athletics game on Sept. 18, with the over available at -104 and the under at -118.

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Guardians vs Athletics Betting Trends

• The Guardians have been victorious in 45, or 51.7%, of the 87 contests they have been chosen as favorites in this season.
• The Guardians have yet to enter a game this year with shorter moneyline odds than -230.
• The Guardians and their opponents have hit the over in 72 of their 145 games with a total this season.
• In 145 games with a line this season, the Guardians have a mark of 68-77-0 against the spread.
• The Athletics are 45-71 in games they were listed as the moneyline underdog (winning 38.8% of those games).
• The Athletics have a record of 5-5 when playing as a moneyline underdog with odds of +190 or longer (50%).
• The Athletics have played in 153 games with a set over/under, and have combined with their opponents to go over the total 79 times (79-72-2).
• The Athletics are 73-80-0 against the spread this season.

Guardians Player Leaders

• Chase DeLauter leads Cleveland in total hits (134) this season while batting .289 with 45 extra-base hits. He has an on-base percentage of .362 and a slugging percentage of .453.
• Among all qualified hitters, he ranks 12th in batting average, his on-base percentage ranks 24th, and he is 43rd in slugging.
• Steven Kwan has a slash line of .277/.375/.344 this season and a team-best OPS of .719.
• His batting average is 28th among qualified players, his on-base percentage 11th, and his slugging percentage 131st.
• Jose Ramirez has collected 101 base hits, an OBP of .319 and a slugging percentage of .364 this season.
• Brayan Rocchio has been key for Cleveland with 126 hits, an OBP of .309 plus a slugging percentage of .375.

Athletics Player Leaders

• Jeff McNeil has a .371 slugging percentage, which paces the Athletics. He's batting .268 with an on-base percentage of .315.
• Including all the qualified hitters in MLB, his batting average is 48th, his on-base percentage ranks 97th, and he is 117th in slugging.
• Shea Langeliers is hitting .265 with 19 doubles, 23 home runs and 34 walks. He's slugging .492 with an on-base percentage of .332.
• Lawrence Butler has put up a team-high OBP (.319), while leading the Athletics in hits (101).
• Zack Gelof has 15 doubles, two triples, 18 home runs and 29 walks while batting .247.

Guardians vs Athletics Head to Head

• 5/3/2026: 7-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/2/2026: 14-6 CLE (Favorite: Athletics, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/1/2026: 8-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/20/2025: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/19/2025: 8-2 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/18/2025: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/22/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/21/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/20/2025: 5-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/21/2024: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)

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