Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 18

Odds updated as of 1:12 a.m.

The Friday schedule in MLB includes a matchup between the Chicago Cubs and the Cincinnati Reds.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Cubs vs Reds Game Info

• Chicago Cubs (85-68) vs. Cincinnati Reds (71-82)
• Date: Friday, September 18, 2026
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-122) | CIN: (+104)
• Spread: CHC: -1.5 (+130) | CIN: +1.5 (-156)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Clay Holmes (Cubs) - 6-7, 2.85 ERA vs Chase Burns (Reds) - 15-3, 2.80 ERA

This contest's pitching matchup is set, as the Cubs will send Clay Holmes (6-7) to the mound, while Chase Burns (15-3) will get the nod for the Reds. When Holmes starts, his team is 6-10-0 against the spread this season. Holmes' team has a record of 6-5 this season when he starts and they are the favorite on the moneyline. The Reds have a 19-9-0 record against the spread in Burns' starts. The Reds have a 7-2 record in Burns' nine starts this season when they were the underdog on the moneyline.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (62.4%)

Cubs vs Reds Moneyline

• The Cubs vs Reds moneyline has Chicago as a -122 favorite, while Cincinnati is a +104 underdog at home.

Cubs vs Reds Spread

• The Cubs are favored by 1.5 runs on the road against the Reds. The Cubs are +130 to cover the spread, while the Reds are -156.

Cubs vs Reds Over/Under

• A combined run total of 8.5 has been set for Cubs-Reds on Sept. 18, with the over at -120 and the under at -102.

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Cubs vs Reds Betting Trends

• The Cubs have been victorious in 57, or 57%, of the 100 contests they have been chosen as favorites in this season.
• Chicago has a record of 45-37 in contests when sportsbooks favor them by -122 or more on the moneyline.
• The Cubs and their opponents have hit the over in 84 of their 148 games with a total set by oddsmakers this season.
• The Cubs have an against the spread record of 71-77-0 in 148 games with a line this season.
• The Reds have won 46.7% of the games this season they were the underdog on the moneyline (49-56).
• Cincinnati is 35-48 (winning 42.2% of its games) when playing as a moneyline underdog of +104 or longer.
• In the 149 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 79 times (79-68-2).
• The Reds have put together a 76-73-0 record ATS this season (covering 51% of the time).

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago in OBP (.375), slugging percentage (.581) and total hits (167) this season. He has a .282 batting average.
• Among qualifying hitters in MLB, he ranks 20th in batting average, 11th in on-base percentage, and second in slugging.
• Alex Bregman is batting .264 with 32 doubles, two triples, 26 home runs and 73 walks, while slugging .458 with an on-base percentage of .354.
• Among all qualified hitters, he ranks 55th in batting average, 39th in on-base percentage and 39th in slugging percentage.
• Seiya Suzuki has collected 136 base hits, an OBP of .365 and a slugging percentage of .469 this season.
• Nico Hoerner has been key for Chicago with 157 hits, an OBP of .315 plus a slugging percentage of .354.

Reds Player Leaders

• Sal Stewart has accumulated a team-best .477 slugging percentage. He's batting .271 with an on-base percentage of .339.
• Including all qualified hitters in MLB, his batting average places him 40th, his on-base percentage ranks 57th, and he is 28th in slugging.
• Elly De La Cruz leads his team with 150 hits and a .362 on-base percentage. He has a batting average of .284 while slugging .517.
• Including all qualifying hitters, he ranks 16th in batting average, 24th in on-base percentage and 11th in slugging percentage.
• JJ Bleday has 16 doubles, two triples, 22 home runs and 69 walks while hitting .213.
• Tyler Stephenson has 21 doubles, 15 home runs and 47 walks while batting .247.

Cubs vs Reds Head to Head

• 8/30/2026: 7-5 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +142)
• 8/29/2026: 17-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -205, Underdog Moneyline: +190)
• 8/28/2026: 10-8 CIN (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -190, Underdog Moneyline: +176)
• 7/12/2026: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/11/2026: 5-3 CHC (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2026: 4-0 CIN (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/7/2026: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/6/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/5/2026: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 9/20/2025: 6-3 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)

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