Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 18

Odds updated as of 6:12 p.m.

On Friday in MLB, the Chicago Cubs are playing the Cincinnati Reds.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Reds Game Info

• Chicago Cubs (85-68) vs. Cincinnati Reds (71-82)
• Date: Friday, September 18, 2026
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-146) | CIN: (+124)
• Spread: CHC: -1.5 (+108) | CIN: +1.5 (-130)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Clay Holmes (Cubs) - 6-7, 2.85 ERA vs Chase Burns (Reds) - 15-3, 2.80 ERA

This contest's pitching matchup is set, as the Cubs will send Clay Holmes (6-7) to the mound, while Chase Burns (15-3) will get the nod for the Reds. Holmes' team is 6-10-0 against the spread in his starts this season. Holmes' team has won 54.5% of his starts when they are favored on the moneyline (6-5). When Burns starts, the Reds have gone 19-9-0 against the spread. The Reds have been the moneyline underdog in nine of Burns' starts this season, and they went 7-2 in those matchups.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (62.9%)

Cubs vs Reds Moneyline

• The moneyline numbers for Cubs vs. Reds reveal Chicago as the favorite (-146) and Cincinnati as the underdog (+124) despite being the home team.

Cubs vs Reds Spread

• The Cubs are favored by 1.5 runs on the road versus the Reds. The Cubs are +108 to cover the spread, while the Reds are -130.

Cubs vs Reds Over/Under

• Cubs versus Reds on Sept. 18 has an over/under of 8.5 runs, with the odds on the over -115 and the under set at -105.

Bet on Chicago Cubs vs. Cincinnati Reds on FanDuel today!

Cubs vs Reds Betting Trends

• The Cubs have been favorites in 100 games this season and have come away with the win 57 times (57%) in those contests.
• This season Chicago has been victorious 30 times in 48 chances when named as a favorite of at least -146 on the moneyline.
• The Cubs' games have gone over the total in 84 of their 148 opportunities.
• The Cubs are 71-77-0 against the spread in their 148 games that had a posted line this season.
• The Reds have won 49 of the 105 games they were listed as the moneyline underdog this season (46.7%).
• Cincinnati is 16-28 (winning just 36.4% of its games) when it has played as a moneyline underdog of +124 or longer.
• The Reds have played in 149 games with a set over/under, and have combined with opponents to go over the total 79 times (79-68-2).
• The Reds have collected a 76-73-0 record ATS this season (covering 51% of the time).

Cubs Player Leaders

• Pete Crow-Armstrong has 167 hits and an OBP of .375 to go with a slugging percentage of .581. All three of those stats lead Chicago hitters this season. He has a .282 batting average, as well.
• Among qualifying hitters in the majors, he ranks 20th in batting average, 11th in on-base percentage, and second in slugging.
• Alex Bregman is hitting .264 with 32 doubles, two triples, 26 home runs and 73 walks. He's slugging .458 with an on-base percentage of .354.
• He ranks 55th in batting average, 39th in on-base percentage and 39th in slugging in the majors.
• Seiya Suzuki is batting .266 with a .469 slugging percentage and 81 RBI this year.
• Nico Hoerner has eight home runs, 69 RBI and a batting average of .263 this season.

Reds Player Leaders

• Sal Stewart has a .477 slugging percentage, which paces the Reds. He's batting .271 with an on-base percentage of .339.
• Including all qualifying players in the majors, he ranks 40th in batting average, 57th in on-base percentage and 28th in slugging percentage.
• Elly De La Cruz's 150 hits and .362 OBP are both team-highs. He has a batting average of .284 while slugging .517.
• Including all qualifying hitters, he is 16th in batting average, 24th in on-base percentage and 11th in slugging percentage.
• JJ Bleday has 16 doubles, two triples, 22 home runs and 69 walks while hitting .213.
• Tyler Stephenson has 21 doubles, 15 home runs and 47 walks while batting .247.

Cubs vs Reds Head to Head

• 8/30/2026: 7-5 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +142)
• 8/29/2026: 17-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -205, Underdog Moneyline: +190)
• 8/28/2026: 10-8 CIN (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -190, Underdog Moneyline: +176)
• 7/12/2026: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/11/2026: 5-3 CHC (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2026: 4-0 CIN (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/7/2026: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/6/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/5/2026: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 9/20/2025: 6-3 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)

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