Guardians vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 1:11 a.m.

The Tuesday schedule in MLB includes a matchup between the Cleveland Guardians and the Houston Astros.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Guardians vs Astros Game Info

• Cleveland Guardians (13-11) vs. Houston Astros (9-15)
• Date: Tuesday, April 21, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and SCHN

Guardians vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-142) | HOU: (+120)
• Spread: CLE: -1.5 (+146) | HOU: +1.5 (-176)
• Total: 8 -- Over: (-115) | Under: (-105)

Guardians vs Astros Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 3-0, 1.05 ERA vs Ryan Weiss (Astros) - 0-2, 6.75 ERA

The Guardians will give the ball to Parker Messick (3-0, 1.05 ERA), who is eyeing win No. 4 on the season, and the Astros will turn to Ryan Weiss (0-2, 6.75 ERA). Messick and his team have covered in each of his four starts with a spread this season. Messick's team won his only start as a favorite this season. Weiss has started just one game with a set spread, which the Astros failed to cover. The Astros have not been the underdog on the moneyline when Weiss starts this season.

Guardians vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (58.1%)

Guardians vs Astros Moneyline

• Cleveland is a -142 favorite on the moneyline, while Houston is a +120 underdog on the road.

Guardians vs Astros Spread

• The Guardians are hosting the Astros and are favored by 1.5 runs on the spread. The Guardians are +146 to cover the runline, with the Astros being -176.

Guardians vs Astros Over/Under

• Guardians versus Astros on April 21 has an over/under of 8 runs, with the odds on the over -115 and the under set at -105.

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Guardians vs Astros Betting Trends

• The Guardians have come away with five wins in the nine contests they have been listed as the favorites in this season.
• These are the best odds of a victory sportsbooks have given Cleveland this season, with a -142 moneyline set for this game.
• The Guardians and their opponents have hit the over in 12 of their 24 games with a total set by oddsmakers this season.
• The Guardians are 14-10-0 against the spread in their 24 games that had a posted line this season.
• The Astros have compiled a 3-4 record in games they were listed as the moneyline underdog (winning 42.9% of those games).
• When it has played as a moneyline underdog with odds of +120 or longer, Houston has a 1-3 record (winning just 25% of its games).
• The Astros have played in 24 games with an over/under set, and have combined with opponents to go over the total 17 times (17-7-0).
• The Astros have gone 9-15-0 against the spread this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 20 hits and a team-best slugging percentage of .494. He's batting .230 with an on-base percentage of .356.
• Among the qualifying hitters in the majors, his batting average ranks 116th, his on-base percentage ranks 63rd, and he is 39th in slugging.
• Ramirez has picked up at least one hit in two games in a row. In his last five games he is hitting .357 with a double, three home runs, seven walks and four RBIs.
• Chase DeLauter is batting .219 with five doubles, five home runs and 11 walks. He's slugging .493 with an on-base percentage of .318.
• His batting average is 130th among qualified players, his on-base percentage 108th, and his slugging percentage 40th.
• Brayan Rocchio has a team-best OPS of .847, fueled by a slash line of .286/.390/.457 this season.
• Rocchio has recorded at least one base hit in seven games in a row. In his last 10 games he is hitting .364 with two doubles, two home runs, four walks and eight RBIs.
• Steven Kwan leads Cleveland with a slugging percentage of .286, fueled by four extra-base hits.

Astros Player Leaders

• Yordan Alvarez has put up a team-best OBP (.459) and slugging percentage (.756), and leads the Astros in hits (28, while batting .326).
• Including all the qualified hitters in MLB, he ranks ninth in batting average, second in on-base percentage and second in slugging percentage.
• Alvarez hopes to build on a seven-game hitting streak in this matchup. In his last 10 games he is batting .310 with four doubles, five home runs, five walks and eight RBIs.
• Christian Walker is hitting .274 with seven doubles, five home runs and 12 walks. He's slugging .536 with an on-base percentage of .367.
• His batting average is 53rd among all qualified players, his on-base percentage ranks 48th, and he is 22nd in slugging.
• Jose Altuve has six doubles, three home runs and 15 walks while batting .281.
• Carlos Correa is batting .275 with five doubles, a home run and 11 walks.

Guardians vs Astros Head to Head

• 4/20/2026: 9-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/9/2025: 4-2 CLE (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/8/2025: 10-6 CLE (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 7/7/2025: 7-5 CLE (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/8/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/7/2025: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/6/2025: 4-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/28/2024: 4-3 HOU (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/27/2024: 5-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/2/2024: 8-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)

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