Guardians vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for April 20

Odds updated as of 6:13 p.m.

The MLB slate on Monday includes the Cleveland Guardians facing the Houston Astros.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this game.

Guardians vs Astros Game Info

• Cleveland Guardians (13-10) vs. Houston Astros (8-15)
• Date: Monday, April 20, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and SCHN

Guardians vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-130) | HOU: (+110)
• Spread: CLE: -1.5 (+172) | HOU: +1.5 (-210)
• Total: 7.5 -- Over: (+100) | Under: (-122)

Guardians vs Astros Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 0-2, 5.03 ERA vs Spencer Arrighetti (Astros) - 1-0, 1.50 ERA

The Guardians will give the nod to Slade Cecconi (0-2, 5.03 ERA), who is eyeing win No. 1 on the season, and the Astros will counter with Spencer Arrighetti (1-0, 1.50 ERA). Cecconi's team is 1-3-0 against the spread in his starts this season. This will be Cecconi's first start this season with his team as the moneyline favorite. Arrighetti has started only one game with a set spread, which the Astros covered. The Astros have not been a moneyline underdog when Arrighetti starts this season.

Guardians vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (58.1%)

Guardians vs Astros Moneyline

• Looking at the moneyline for Astros-Guardians, Houston is the underdog at +110, and Cleveland is -130 playing at home.

Guardians vs Astros Spread

• The Astros are at the Guardians, and are +1.5 on the runline. The Astros are +172 to cover the spread, and the Guardians are -210.

Guardians vs Astros Over/Under

• The over/under for Guardians-Astros on April 20 is 7.5. The over is +100, and the under is -122.

Bet on Cleveland Guardians vs. Houston Astros on FanDuel today!

Guardians vs Astros Betting Trends

• The Guardians have come away with five wins in the eight contests they have been listed as the favorites in this season.
• Cleveland has a record of 2-1 in contests when oddsmakers favor them by -130 or more on the moneyline.
• The Guardians and their opponents have gone over the total this season in 11 of their 23 opportunities.
• In 23 games with a line this season, the Guardians have a mark of 14-9-0 against the spread.
• The Astros have won two of the six games they were listed as the moneyline underdog this season (33.3%).
• When it has played as a moneyline underdog with odds of +110 or longer, Houston has a 1-4 record (winning just 20% of its games).
• The Astros have combined with opponents to go over the total 16 times this season for a 16-7-0 record against the over/under.
• The Astros have put together an 8-15-0 record ATS this season (covering just 34.8% of the time).

Guardians Player Leaders

• Jose Ramirez has four doubles, six home runs and 16 walks while batting .229. He has an on-base percentage of .354 and a slugging percentage of .494.
• Among all qualified batters, he ranks 119th in batting average, his on-base percentage ranks 61st, and he is 42nd in slugging.
• Chase DeLauter has 16 hits, which ranks first among Cleveland batters this season. He's batting .232 with 10 extra-base hits. He's also slugging .522 with an on-base percentage of .325.
• Among qualified batters, his batting average ranks him 115th, his on-base percentage 102nd, and his slugging percentage 27th.
• Brayan Rocchio leads Cleveland in OBP (.359) this season, fueled by 17 hits.
• Rocchio has recorded a hit in six games in a row. During his last 10 outings he is hitting .303 with a double, two home runs, four walks and nine RBIs.
• Steven Kwan leads Cleveland with a slugging percentage of .299, fueled by four extra-base hits.

Astros Player Leaders

• Yordan Alvarez has an on-base percentage of .471, a slugging percentage of .790, and has 27 hits, all club-bests for the Astros (while batting .333).
• Including all qualifying hitters, he ranks sixth in batting average, while his on-base percentage is second and he is second in slugging.
• Alvarez hopes to build on a six-game hitting streak in this matchup. During his last 10 games he is batting .350 with four doubles, six home runs, six walks and 11 RBIs.
• Christian Walker is hitting .253 with six doubles, four home runs and 12 walks. He's slugging .481 with an on-base percentage of .355.
• Including all qualifying players, he is 84th in batting average, 59th in on-base percentage and 46th in slugging percentage.
• Jose Altuve is hitting .298 with six doubles, three home runs and 15 walks.
• Carlos Correa has five doubles, a home run and 11 walks while batting .253.

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