Giants vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for June 4

Odds updated as of 9:11 p.m.

MLB action on Wednesday includes the San Diego Padres taking on the San Francisco Giants.

We've got you covered, in terms of the most important info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Giants Game Info

• San Diego Padres (35-24) vs. San Francisco Giants (33-28)
• Date: Wednesday, June 4, 2025
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and SDPA

Padres vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-116) | SF: (-102)
• Spread: SD: -1.5 (+158) | SF: +1.5 (-192)
• Total: 7 -- Over: (-122) | Under: (-100)

Padres vs Giants Probable Starting Pitchers

Probable Pitchers: Nick Pivetta (Padres) - 6-2, 2.74 ERA vs Kyle Harrison (Giants) - 1-1, 2.51 ERA

This contest's pitching matchup is set, as the Padres will send Nick Pivetta (6-2) to the mound, while Kyle Harrison (1-1) will get the nod for the Giants. Pivetta's team is 7-4-0 against the spread in his starts this season. When Pivetta starts a game and his team is the favorite on the moneyline, they have a record of 3-2. Harrison has started two games with set spreads, and the Giants went 1-1-0. The Giants have always been the moneyline underdog when Harrison starts this season.

Padres vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (54.8%)

Padres vs Giants Moneyline

• The moneyline numbers for Padres vs. Giants reveal San Diego as the favorite (-116) and San Francisco as the underdog (-102) despite being the home team.

Padres vs Giants Spread

• The Padres are at the Giants and are favored by 1.5 runs (+158 to cover) on the runline. San Francisco is -192 to cover.

Padres vs Giants Over/Under

• An over/under of 7 has been set for Padres-Giants on June 4, with the over being -122 and the under -100.

Bet on San Diego Padres vs. San Francisco Giants on FanDuel today!

Padres vs Giants Betting Trends

• The Padres have been favorites in 32 games this season and have come away with the win 20 times (62.5%) in those contests.
• San Diego has a record of 20-12 in contests when sportsbooks favor them by -116 or more on the moneyline.
• The Padres' games have gone over the total in 24 of their 58 opportunities.
• The Padres have posted a record of 31-27-0 against the spread this season.
• The Giants have gone 10-11 in games they were the underdog on the moneyline (winning 47.6% of those games).
• San Francisco has a record of 7-9 when playing as a moneyline underdog with odds of -102 or longer (43.8%).
• In the 61 games oddsmakers have set an over/under for the Giants, they have combined with opponents to go over the total 27 times (27-33-1).
• The Giants have a 27-34-0 record against the spread this season.

Padres Player Leaders

• Manny Machado leads San Diego in OBP (.380), slugging percentage (.489) and total hits (69) this season. He has a .315 batting average.
• Among qualified hitters in MLB, he is 10th in batting average, 23rd in on-base percentage, and 32nd in slugging.
• Fernando Tatis Jr. is batting .265 with seven doubles, a triple, 13 home runs and 25 walks, while slugging .478 with an on-base percentage of .340.
• His batting average ranks 67th among qualified players, his on-base percentage 61st, and his slugging percentage 41st.
• Tatis heads into this game looking to extend his two-game hit streak. During his last five outings he is hitting .176 with four walks.
• Luis Arraez is batting .283 with a .410 slugging percentage and 21 RBI this year.
• Gavin Sheets is batting .260 with a .318 OBP and 34 RBI for San Diego this season.

Giants Player Leaders

• Jung Hoo Lee has 14 doubles, two triples, six home runs and 15 walks while batting .269. He's slugging .423 with an on-base percentage of .316.
• Including all the qualified players in the majors, his batting average ranks 60th, his on-base percentage ranks 100th, and he is 85th in slugging.
• Heliot Ramos paces his team with 67 hits and a .358 on-base percentage, with a team-leading .493 slugging percentage. He has a batting average of .293.
• Including all qualified hitters, he is 19th in batting average, 38th in on-base percentage and 30th in slugging percentage.
• Wilmer Flores is hitting .253 with four doubles, 10 home runs and 17 walks.
• Matt Chapman has 10 doubles, 10 home runs and 39 walks while hitting .236.

Padres vs Giants Head to Head

• 6/3/2025: 3-2 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/2/2025: 1-0 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 4/30/2025: 5-3 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/29/2025: 7-4 SD (Favorite: Giants, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/15/2024: 4-3 SD (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/14/2024: 8-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/13/2024: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 6.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/8/2024: 7-6 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/7/2024: 6-3 SF (Favorite: Padres, Spread: -1.5, Total: 6.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/6/2024: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)

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