Giants vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 1

Odds updated as of 11:20 p.m.

The MLB's Wednesday slate includes the San Francisco Giants taking on the San Diego Padres.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Giants vs Padres Game Info

• San Francisco Giants (1-3) vs. San Diego Padres (1-3)
• Date: Wednesday, April 1, 2026
• Time: 4:10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and NBCS-BA

Giants vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-138) | SD: (+118)
• Spread: SF: -1.5 (+122) | SD: +1.5 (-146)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Giants vs Padres Probable Starting Pitchers

Probable Pitchers: Adrian Houser (Giants) - 0-0, 0.00 ERA vs Nick Pivetta (Padres) - 0-1, 18.00 ERA

The Giants will look to Adrian Houser against the Padres and Nick Pivetta. Houser and his team were 13-8-0 against the spread when he pitched last season. Houser and his team won 83.3% of the games he started as the moneyline favorite last season, with a record of 5-1. Pivetta has started only one game with a set spread, which the Padres failed to cover. The Padres were named the moneyline underdog for one Pivetta start this season -- they lost.

Giants vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59.5%)

Giants vs Padres Moneyline

• San Diego is the underdog, +118 on the moneyline, while San Francisco is a -138 favorite despite being on the road.

Giants vs Padres Spread

• The Padres are at +1.5 on the runline against the Giants. The Padres are -146 to cover the spread, and the Giants are +122.

Giants vs Padres Over/Under

• A combined run total of 7.5 has been set for Giants-Padres on April 1, with the over at -118 and the under at -104.

Bet on San Francisco Giants vs. San Diego Padres on FanDuel today!

Giants vs Padres Betting Trends

• The Giants came away with 50 wins in the 94 contests they were listed as the favorites last season.
• Last year, San Francisco won 37 of 61 games when listed as at least -138 on the moneyline.
• The Giants and their opponents hit the over in 77 of their 161 games with a total last season.
• The Padres won 34 of the 70 games they were the underdog on the moneyline last season (48.6%).
• When playing as a moneyline underdog with odds of +118 or longer last year, San Diego went 15-20 (42.9%).
• The Padres played in 163 games with a set over/under last season, and combined with their opponents to go over the total 70 times (70-90-3).

Giants Player Leaders

• Rafael Devers had 153 hits and an OBP of .372 last season.
• Luis Arraez had an OPS of .719, fueled by an OBP of .327 and a slugging percentage of .392.
• Willy Adames ended his last campaign with 133 hits, an OBP of .318, plus a slugging percentage of .421.
• Jung Hoo Lee slashed .266/.327/.407 and finished with an OPS of .735.

Padres Player Leaders

• Fernando Tatis Jr. had a .368 on-base percentage while batting .268 last season.
• Manny Machado collected 169 total hits while slugging .460.
• Ramon Laureano had 26 doubles, two triples, 24 home runs and 35 walks while hitting .281 last season.
• Xander Bogaerts hit .263 with 30 doubles, 11 home runs and 48 walks.

Giants vs Padres Head to Head

• 3/30/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 8/21/2025: 8-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/20/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/19/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/18/2025: 4-3 SF (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/13/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/12/2025: 5-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2025: 4-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/5/2025: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/4/2025: 6-5 SF (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!