Giants vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for March 31

Odds updated as of 9:12 p.m.

The MLB schedule on Tuesday includes the San Francisco Giants facing the San Diego Padres.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Giants vs Padres Game Info

• San Francisco Giants (1-3) vs. San Diego Padres (1-3)
• Date: Tuesday, March 31, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and NBCS-BA

Giants vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-138) | SD: (+118)
• Spread: SF: -1.5 (+122) | SD: +1.5 (-146)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Giants vs Padres Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 0-1, 10.80 ERA vs German Marquez (Padres) - 0-0, 0.00 ERA

The Giants will give the nod to Logan Webb versus the Padres and German Marquez. Webb and his team failed to cover the spread in his only opportunity this season as a starter. This will be Webb's first game as the moneyline favorite this season. Last season Marquez and his team had an 8-18-0 record against the spread when he pitched. Marquez and his team went 6-18 in the 24 games he pitched when they were the underdog on the moneyline a season ago.

Giants vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (53.7%)

Giants vs Padres Moneyline

• San Francisco is the favorite, -138 on the moneyline, while San Diego is a +118 underdog despite being at home.

Giants vs Padres Spread

• The Padres are at +1.5 on the runline against the Giants. The Padres are -146 to cover the spread, and the Giants are +122.

Giants vs Padres Over/Under

• An over/under of 7.5 has been set for Giants-Padres on March 31, with the over being -118 and the under -104.

Bet on San Francisco Giants vs. San Diego Padres on FanDuel today!

Giants vs Padres Betting Trends

• The Giants came away with 50 wins in the 94 contests they were listed as the favorites last season.
• Last season San Francisco came away with a win 37 times in 61 chances when named as a favorite of at least -138 or shorter on the moneyline.
• The Giants and their opponents hit the over in 77 of their 161 games with a total last season.
• The Padres won 48.6% of the games last season they were the moneyline underdog (34-36).
• San Diego went 15-20 in games it played as a moneyline underdog with odds of +118 or longer (42.9%).
• The Padres played in 163 games with a set over/under last season, and combined with their opponents to go over the total 70 times (70-90-3).

Giants Player Leaders

• Rafael Devers had 153 hits and an OBP of .372 last season.
• Luis Arraez had an OPS of .719, fueled by an OBP of .327 and a slugging percentage of .392.
• Last season, Willy Adames finished with 30 home runs, 87 RBI and a batting average of .225 last season.
• Jung Hoo Lee slashed .266/.327/.407 and finished with an OPS of .735.

Padres Player Leaders

• Fernando Tatis Jr. had a .368 on-base percentage while batting .268 last season.
• Manny Machado racked up 169 hits and slugged .460.
• Ramon Laureano had 26 doubles, two triples, 24 home runs and 35 walks while hitting .281 last season.
• Xander Bogaerts hit .263 with 30 doubles, 11 home runs and 48 walks.

Giants vs Padres Head to Head

• 3/30/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 8/21/2025: 8-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/20/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/19/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/18/2025: 4-3 SF (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/13/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/12/2025: 5-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2025: 4-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/5/2025: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/4/2025: 6-5 SF (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)

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