Duke vs Virginia Prediction, Odds, Picks, Best Bets for Week 12 2025

The Duke Blue Devils will face the Virginia Cavaliers in college football action on Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info about today's NCAA football betting odds.

Duke vs Virginia Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Duke: (-196) | Virginia: (+164)
• Spread: Duke: -4.5 (-114) | Virginia: +4.5 (-106)
• Total: 60.5 -- Over: (-110) | Under: (-110)

Duke vs Virginia Betting Trends

• Duke has beaten the spread four times in nine games.
• As a 4.5-point or greater favorite, Duke has one win ATS (1-2) this season.
• There have been seven Duke games (of nine) that went over the total this season.
• Against the spread, Virginia is 6-4-0 this season.
• Virginia has covered every time (2-0) as a 4.5-point or greater underdog this season.
• There have been five Virginia games (out of 10) that hit the over this year.

Duke vs Virginia Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Blue Devils win (53.2%)

Duke vs Virginia Point Spread

Virginia is an underdog by 4.5 points against Duke. Virginia is -106 to cover the spread, and Duke is -114.

Duke vs Virginia Over/Under

An over/under of 60.5 has been set for Duke-Virginia on Nov. 15, with the over being -110 and the under -110.

Duke vs Virginia Moneyline

Duke is the favorite, -196 on the moneyline, while Virginia is a +164 underdog.

Duke vs. Virginia Points Insights

Duke vs. Virginia Game Info

• Game day: Saturday, November 15, 2025
• Game time: 3:30 p.m. ET
• TV channel: ESPN2
• Location: Wilmington, North Carolina
• Stadium: Brooks Field at Wallace Wade Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Duke vs. Virginia analysis on FanDuel Research.