Duke vs St. John's College Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Sweet 16

The No. 5-seed St. John's Red Storm (30-6) are ready for a Sweet 16 matchup against the No. 1 Duke Blue Devils (34-2) on Friday at 7:10 p.m. ET as the NCAA Tournament continues at Capital One Arena airing on CBS.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. St. John's Game Info and Odds

• Game day: Friday, March 27, 2026
• Game time: 7:10 p.m. ET
• TV channel: CBS
• Location: Washington D.C.
• Arena: Capital One Arena

Duke vs. St. John's Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (65%)

Before making a wager on Friday's Duke-St. John's spread (Duke -6.5) or total (140.5 points), check out the betting trends and insights below.

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Duke vs. St. John's: ATS Betting Stats and Trends

• Duke has put together a 19-17-0 ATS record so far this year.
• St. John's is 21-15-0 ATS this season.
• The Blue Devils have covered the spread in a lower percentage of their home games than away games. They have covered six times in 15 games at home, and they've covered eight times in 11 games on the road.
• Against the spread, the Red Storm have had better results on the road (7-3-0) than at home (8-9-0).

Duke vs. St. John's: Moneyline Betting Stats

• Duke has come away with 27 wins in the 29 contests it has been listed as the moneyline favorite in this season.
• This year, the Blue Devils have won 25 of 27 games when listed as at least -280 or better on the moneyline.
• St. John's has won 40% of the games this season it was the moneyline underdog (2-3).
• The Red Storm have yet to play as a moneyline underdog of +225 or longer.
• The moneyline set for this matchup implies Duke has a 73.7% chance of walking away with the win.

Duke vs. St. John's Head-to-Head Comparison

• Duke averages 81.9 points per game (51st in college basketball) while allowing 63.1 per contest (third in college basketball). It has a +680 scoring differential overall and outscores opponents by 18.8 points per game.
• Cameron Boozer's 22.4 points per game lead Duke and are ninth in the nation.
• St. John's outscores opponents by 11.7 points per game (posting 81.1 points per game, 63rd in college basketball, and conceding 69.4 per contest, 62nd in college basketball) and has a +422 scoring differential.
• Zuby Ejiofor's team-leading 16.3 points per game rank him 197th in the nation.
• The Blue Devils rank eighth in the country at 37.5 rebounds per game. That's 11.1 more than the 26.4 their opponents average.
• Boozer paces the team with 10.3 rebounds per game (11th in college basketball play).
• The Red Storm are 44th in the nation at 34.9 rebounds per game. That's 4.4 more than the 30.5 their opponents average.
• Ejiofor averages 7.3 rebounds per game (125th in college basketball) to lead the Red Storm.
• Duke's 107.8 points per 100 possessions on offense rank 13th in college basketball, and the 82.9 points it allows per 100 possessions rank second in college basketball.
• The Red Storm's 100.6 points per 100 possessions on offense rank 103rd in college basketball, and the 86.1 points they allow per 100 possessions rank 10th in college basketball.

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