Duke vs Siena College Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament First Round

A first-round NCAA Tournament matchup will see the No. 1-seed Duke Blue Devils (32-2) hit the court against the No. 16 seed Siena Saints (23-11) on Thursday at Bon Secours Wellness Arena. The matchup starts at 2:50 p.m. ET, on CBS.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Siena Game Info and Odds

• Game day: Thursday, March 19, 2026
• Game time: 2:50 p.m. ET
• TV channel: CBS
• Location: Greenville, South Carolina
• Arena: Bon Secours Wellness Arena

Duke vs. Siena Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (88.8%)

Take a look at the betting trends and insights below before making a wager on Thursday's Duke-Siena spread (Duke -27.5) or total (136.5 points).

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Duke vs. Siena: ATS Betting Stats and Trends

• Duke has covered 18 times in 34 chances against the spread this season.
• Siena has won 20 games against the spread this season, while failing to cover 14 times.
• The Blue Devils have covered the spread in a lower percentage of their home games than road games. They have covered six times in 15 games when playing at home, and they've covered eight times in 11 games on the road.
• The Saints have been better against the spread away (9-7-0) than at home (7-6-0) this year.

Duke vs. Siena: Moneyline Betting Stats

• Duke has been chosen as the moneyline favorite in 27 games this year and has walked away with the win 25 times (92.6%) in those games.
• The Blue Devils have yet to play a game this season with better moneyline odds than -50000.
• Siena is 2-4 in games it was listed as the moneyline underdog (winning 33.3% of those games).
• The Saints have yet to play as a moneyline underdog of +5500 or longer.
• The moneyline set for this matchup implies Duke has a 99.8% chance of walking away with the win.

Duke vs. Siena Head-to-Head Comparison

• Offensively, Duke was the 11th-best team in the country (83.2 points per game) last season. On defense, it was seventh-best (62.8 points allowed per game).
• Last year, Duke was 24th-best in college basketball in rebounds (35.6 per game) and 12th-best in rebounds conceded (27.3).
• At 16.9 assists per game, Duke was 17th-best in college basketball last year.
• In terms of turnovers, Duke was ninth-best in the nation in committing them (8.9 per game) last year. It was 265th in forcing them (10.4 per game).
• Siena ranked 225th in the nation last year with 72.2 points per game. At the other end of the court, it ranked 185th with 72.1 points allowed per contest.
• Last season Siena pulled down 29.7 boards per game (310th-ranked in college basketball) and ceded 31.1 rebounds per contest (172nd-ranked).
• Last season Siena ranked 300th in college basketball in assists, delivering 11.8 per game.
• With 11.2 turnovers per game, Siena ranked 186th in college basketball. It forced 11.9 turnovers per contest, which ranked 121st in college basketball.

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