Duke vs Indiana State College Basketball Prediction, Odds, Picks, Best Bets for Nov. 14

The Duke Blue Devils (3-0) will try to extend a three-game winning streak when they host the Indiana State Sycamores (2-1) on November 14, 2025 at Cameron Indoor Stadium.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Indiana State Game Info and Odds

• Game day: Friday, November 14, 2025
• Game time: 7 p.m. ET
• TV channel: ACC Network
• Location: Durham, North Carolina
• Arena: Cameron Indoor Stadium

Before you place a wager on Duke-Indiana State matchup (in which Duke is a 38.5-point favorite and the total has been set at 163.5 points), below are some betting insights and trends for Friday's game.

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Duke vs. Indiana State: ATS Betting Stats and Trends

• Duke compiled a 25-14-0 ATS record last year.
• Indiana State put together a 16-14-0 ATS record last season.
• In home games last season, the Blue Devils owned a worse record against the spread (11-6-0) compared to their ATS record in away games (9-2-0).
• The Sycamores performed better against the spread on the road (7-6-0) than at home (6-6-0) last season.

Duke vs. Indiana State Head-to-Head Comparison

• Offensively, Duke was the 11th-best team in the country (83.2 points per game) last year. Defensively, it was seventh-best (62.8 points conceded per game).
• Last season, Duke was 24th-best in the country in rebounds (35.6 per game) and 12th-best in rebounds allowed (27.3).
• With 16.9 assists per game, Duke was 17th-best in college basketball last season.
• In terms of turnovers, Duke was ninth-best in the country in committing them (8.9 per game) last year. It was 265th in forcing them (10.4 per game).
• Indiana State ranked 36th in college basketball with 80.1 points per game last season, but on defense it was less effective, ceding 79.5 points per game (18th-worst in college basketball).
• Indiana State was 162nd in the nation with 32.3 rebounds per game. Meanwhile, it ranked 211th with 31.7 rebounds allowed per game.
• Last year Indiana State ranked 53rd in college basketball in assists, dishing out 15.7 per game.
• Indiana State fell short in the turnover area last season, ranking 17th-worst in college basketball with 13.5 turnovers per game. It ranked 176th with 11.3 forced turnovers per contest.

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