Duke vs Clemson College Basketball Prediction, Odds, Picks, Best Bets for ACC Tournament

The No. 1 seed Duke Blue Devils (30-2, 17-1 ACC) will play in the ACC tournament against the No. 5 seed Clemson Tigers (24-9, 12-6 ACC), Friday at 9:30 p.m. ET live on ESPN2.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Clemson Game Info and Odds

• Game day: Friday, March 13, 2026
• Game time: 9:30 p.m. ET
• TV channel: ESPN2
• Location: Charlotte, North Carolina
• Arena: Spectrum Center

Duke vs. Clemson Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (70.2%)

Before you decide to wager on Duke-Clemson outing (in which Duke is a 10.5-point favorite and the total has been set at 135.5 points), below are a few betting trends and insights for Friday's game.

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Duke vs. Clemson: ATS Betting Stats and Trends

• Duke has won 17 games against the spread this season, while failing to cover 15 times.
• Clemson has compiled a 17-16-0 ATS record so far this season.
• When the spread is set as 10.5 or more this season, Duke (12-12) covers a lower percentage of those games when it is the favorite (50%) than Clemson (2-0) does as the underdog (100%).
• The Blue Devils own a worse record against the spread at home (6-9-0) than they do in away games (8-3-0).
• Against the spread, the Tigers have had better results on the road (7-4-0) than at home (7-9-0).
• Duke has 10 wins against the spread in 19 conference games this year.
• Clemson has 11 wins against the spread in 20 ACC games this year.

Duke vs. Clemson: Moneyline Betting Stats

• Duke has been chosen as the moneyline favorite in 25 games this year and has walked away with the win 23 times (92%) in those games.
• The Blue Devils have yet to lose in 17 games when named as moneyline favorite of -649 or better.
• Clemson has gone 1-4 in games it was listed as the moneyline underdog (winning 20% of those games).
• The Tigers have played as a moneyline underdog of +460 or longer in only one game this season, which they lost.
• The moneyline set for this matchup implies Duke has a 86.6% chance of coming away with a victory in the contest.

Duke vs. Clemson Head-to-Head Comparison

• On offense, Duke was the 11th-best squad in college basketball (83.2 points per game) last season. On defense, it was seventh-best (62.8 points conceded per game).
• Duke was the 24th-best team in the nation in rebounds per game (35.6) and 12th-best in rebounds allowed (27.3) last season.
• Duke was 17th-best in the country in assists (16.9 per game) last year.
• In terms of turnovers, Duke was ninth-best in the nation in committing them (8.9 per game) last year. It was 265th in forcing them (10.4 per game).
• Clemson was 112th in college basketball last season with 76.1 points per game. At the other end, it ranked 27th with 65.8 points allowed per game.
• Last year Clemson averaged 32.4 rebounds per game (156th-ranked in college basketball) and ceded 29.8 rebounds per contest (90th-ranked).
• Clemson dished out 14.2 dimes per game, which ranked them 124th in the country.
• With 10.1 turnovers per game, Clemson ranked 79th in college basketball. It forced 12.3 turnovers per contest, which ranked 85th in college basketball.

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