Dodgers vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 6:14 a.m.

The MLB slate on Wednesday includes the Los Angeles Dodgers taking on the San Francisco Giants.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Dodgers vs Giants Game Info

• Los Angeles Dodgers (16-7) vs. San Francisco Giants (10-13)
• Date: Wednesday, April 22, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and SportsNet LA

Dodgers vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-210) | SF: (+176)
• Spread: LAD: -1.5 (-120) | SF: +1.5 (+100)
• Total: 7.5 -- Over: (-122) | Under: (+100)

Dodgers vs Giants Probable Starting Pitchers

Probable Pitchers: Shohei Ohtani (Dodgers) - 2-0, 0.50 ERA vs Tyler Mahle (Giants) - 0-3, 7.23 ERA

The probable pitchers are Shohei Ohtani (2-0) for the Dodgers and Tyler Mahle (0-3) for the Giants. Ohtani and his team have a record of 2-1-0 against the spread when he starts. Ohtani's team is 2-1 this season when he starts and they are the moneyline favorite. The Giants have gone 1-3-0 ATS in Mahle's four starts with a set spread. The Giants have a 1-2 record in Mahle's three starts this season when they were the underdog on the moneyline.

Dodgers vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (60.2%)

Dodgers vs Giants Moneyline

• Los Angeles is a -210 favorite on the moneyline, while San Francisco is a +176 underdog at home.

Dodgers vs Giants Spread

• The Giants are hosting the Dodgers, and are +1.5 on the runline. The Giants are -120 to cover the spread, and the Dodgers are +100.

Dodgers vs Giants Over/Under

• A combined run total of 7.5 has been set for Dodgers-Giants on April 22, with the over at -122 and the under at +100.

Bet on Los Angeles Dodgers vs. San Francisco Giants on FanDuel today!

Dodgers vs Giants Betting Trends

• The Dodgers have won in 16, or 69.6%, of the 23 contests they have been named as odds-on favorites in this year.
• This year Los Angeles has won nine of 11 games when listed as at least -210 on the moneyline.
• Contests with the Dodgers have gone over the total set by oddsmakers in 11 of 23 chances this season.
• The Dodgers are 12-11-0 against the spread in their 23 games with a line set by sportsbooks this season.
• The Giants have gone 7-8 in games they were the underdog on the moneyline (winning 46.7% of those games).
• San Francisco has not yet played a game with moneyline odds of +176 or longer.
• The Giants have combined with opponents to hit the over on the total 10 times this season for a 10-10-3 record against the over/under.
• The Giants are 8-15-0 ATS this season.

Dodgers Player Leaders

• Andy Pages leads Los Angeles OPS (1.009) this season. He has a .366 batting average, an on-base percentage of .411, and a slugging percentage of .598.
• Among all qualified hitters in MLB, he ranks first in batting average, 10th in on-base percentage, and eighth in slugging.
• Freddie Freeman is batting .289 with seven doubles, a triple, three home runs and nine walks, while slugging .506 with an on-base percentage of .366.
• Among all qualifying players, he is 30th in batting average, 44th in on-base percentage and 31st in slugging percentage.
• Ohtani has 23 hits this season and has a slash line of .271/.396/.494.
• Ohtani heads into this matchup with five games in a row with at least one hit. In his last five games he is hitting .318 with three doubles, two walks and an RBI.
• Max Muncy has 23 hits, which ranks first among Los Angeles hitters this season, while batting .291 with nine extra-base hits.

Giants Player Leaders

• Luis Arraez has a .360 slugging percentage, which leads the Giants. He's batting .302 with an on-base percentage of .333.
• Including all qualified hitters in the majors, he ranks 19th in batting average, 88th in on-base percentage and 117th in slugging percentage.
• Matt Chapman leads his team with a .385 slugging percentage. He has a batting average of .286 with an on-base percentage of .337.
• He ranks 34th in batting average, 79th in on-base percentage and 95th in slugging percentage in MLB.
• Jung Hoo Lee is hitting .259 with six doubles, a home run and seven walks.
• Willy Adames has 10 doubles, three home runs and five walks while batting .247.

Dodgers vs Giants Head to Head

• 4/21/2026: 3-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -186, Underdog Moneyline: +144)
• 9/21/2025: 3-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 9/20/2025: 7-5 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 9/19/2025: 6-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/18/2025: 2-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/14/2025: 10-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/13/2025: 13-7 LAD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/12/2025: 5-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/13/2025: 5-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/12/2025: 2-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)

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