Dodgers vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 9:11 p.m.

The Los Angeles Dodgers versus the San Francisco Giants is on the MLB schedule for Wednesday.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Dodgers vs Giants Game Info

• Los Angeles Dodgers (16-7) vs. San Francisco Giants (10-13)
• Date: Wednesday, April 22, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and SportsNet LA

Dodgers vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-210) | SF: (+176)
• Spread: LAD: -1.5 (-118) | SF: +1.5 (-102)
• Total: 7.5 -- Over: (-122) | Under: (+100)

Dodgers vs Giants Probable Starting Pitchers

Probable Pitchers: Shohei Ohtani (Dodgers) - 2-0, 0.50 ERA vs Tyler Mahle (Giants) - 0-3, 7.23 ERA

The probable starters are Shohei Ohtani (2-0) for the Dodgers and Tyler Mahle (0-3) for the Giants. Ohtani's team is 2-1-0 against the spread this season in his starts. Ohtani's team has a record of 2-1 this season when he starts and they are the favorite on the moneyline. The Giants are 1-3-0 against the spread when Mahle starts. The Giants have been the moneyline underdog in three of Mahle's starts this season, and they went 1-2 in those games.

Dodgers vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (59.8%)

Dodgers vs Giants Moneyline

• Looking at the moneyline for Giants-Dodgers, San Francisco is the underdog at +176, and Los Angeles is -210 playing on the road.

Dodgers vs Giants Spread

• The Giants are +1.5 on the run line against the Dodgers. The Giants are -102 to cover, and the Dodgers are -118.

Dodgers vs Giants Over/Under

• A combined run total of 7.5 has been set for Dodgers-Giants on April 22, with the over at -122 and the under at +100.

Bet on Los Angeles Dodgers vs. San Francisco Giants on FanDuel today!

Dodgers vs Giants Betting Trends

• The Dodgers have won in 16, or 69.6%, of the 23 contests they have been named as odds-on favorites in this year.
• This season Los Angeles has come away with a win nine times in 11 chances when named as a favorite of at least -210 on the moneyline.
• The Dodgers and their opponents have hit the over in 11 of their 23 games with a total set by oddsmakers this season.
• In 23 games with a line this season, the Dodgers have a mark of 12-11-0 against the spread.
• The Giants have won 46.7% of the games this season they were the underdog on the moneyline (7-8).
• San Francisco has not played a game this season with moneyline odds of +176 or longer.
• In the 23 games oddsmakers have set an over/under for the Giants, they have combined with opponents to go over the total 10 times (10-10-3).
• The Giants have covered only 34.8% of their games this season, going 8-15-0 against the spread.

Dodgers Player Leaders

• Andy Pages has an OPS of 1.009, fueled by an OBP of .411 to go with a slugging percentage of .598. He has a .366 batting average, as well.
• Among all qualifying batters in baseball, he ranks first in batting average, 10th in on-base percentage, and seventh in slugging.
• Freddie Freeman is batting .289 with seven doubles, a triple, three home runs and nine walks. He's slugging .506 with an on-base percentage of .366.
• Among qualifying batters, he ranks 31st in batting average, 38th in on-base percentage and 30th in slugging percentage.
• Ohtani has collected 23 base hits, an OBP of .396 and a slugging percentage of .494 this season.
• Ohtani heads into this game with five games in a row with at least one hit. In his last five games he is batting .318 with three doubles, two walks and an RBI.
• Max Muncy has 23 hits, which ranks first among Los Angeles hitters this season, while batting .291 with nine extra-base hits.

Giants Player Leaders

• Luis Arraez has accumulated a slugging percentage of .360, a team-best for the Giants. He's batting .302 with an on-base percentage of .333.
• Including all qualified hitters in the big leagues, his batting average places him 19th, his on-base percentage ranks 85th, and he is 119th in slugging.
• Matt Chapman paces his team with a .385 slugging percentage. He has a batting average of .286 with an on-base percentage of .337.
• Including all qualifying players, he is 34th in batting average, 79th in on-base percentage and 98th in slugging percentage.
• Jung Hoo Lee is hitting .259 with six doubles, a home run and seven walks.
• Willy Adames has 10 doubles, three home runs and five walks while hitting .247.

Dodgers vs Giants Head to Head

• 4/21/2026: 3-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -186, Underdog Moneyline: +144)
• 9/21/2025: 3-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 9/20/2025: 7-5 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 9/19/2025: 6-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/18/2025: 2-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/14/2025: 10-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/13/2025: 13-7 LAD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/12/2025: 5-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/13/2025: 5-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/12/2025: 2-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!