Diamondbacks vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 6:14 a.m.

In MLB action on Wednesday, the Arizona Diamondbacks take on the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Diamondbacks vs White Sox Game Info

• Arizona Diamondbacks (13-10) vs. Chicago White Sox (9-14)
• Date: Wednesday, April 22, 2026
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: Dbacks.TV and CHSN

Diamondbacks vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-152) | CHW: (+128)
• Spread: ARI: -1.5 (+130) | CHW: +1.5 (-156)
• Total: 9 -- Over: (-122) | Under: (+100)

Diamondbacks vs White Sox Probable Starting Pitchers

Probable Pitchers: Eduardo Rodríguez (Diamondbacks) - 1-0, 1.96 ERA vs Anthony Kay (White Sox) - 1-0, 2.60 ERA

The probable pitchers are Eduardo Rodriguez (1-0) for the Diamondbacks and Anthony Kay (1-0) for the White Sox. When Rodriguez starts, his team is 3-1-0 against the spread this season. This will be Rodriguez's first start this season with his team as the moneyline favorite. Kay has started two games with set spreads, and the White Sox went 1-1-0. The White Sox were named the moneyline underdog for two Kay starts this season -- they split the games.

Diamondbacks vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (64.9%)

Diamondbacks vs White Sox Moneyline

• Arizona is a -152 favorite on the moneyline, while Chicago is a +128 underdog on the road.

Diamondbacks vs White Sox Spread

• The Diamondbacks are 1.5-run home favorites on the runline against the White Sox. The Diamondbacks are +130 to cover, and the White Sox are -156.

Diamondbacks vs White Sox Over/Under

• Diamondbacks versus White Sox on April 22 has an over/under of 9 runs, with the odds on the over -122 and the under set at +100.

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Diamondbacks vs White Sox Betting Trends

• The Diamondbacks have been chosen as favorites in six games this year and have walked away with the win five times (83.3%) in those games.
• Arizona has played as a favorite of -152 or more just one time this year and came away with a win in that game.
• The Diamondbacks and their opponents have gone over the total this season in 14 of their 23 opportunities.
• The Diamondbacks have posted a record of 17-6-0 against the spread this season.
• The White Sox have won 36.4% of the games this season they were the underdog on the moneyline (8-14).
• Chicago has gone 5-7 in games it has played as a moneyline underdog with odds of +128 or longer (41.7%).
• The White Sox have had an over/under set by oddsmakers 22 times, and have combined with opponents to go over the total in 14 of those games (14-8-0).
• The White Sox are 10-12-0 against the spread this season.

Diamondbacks Player Leaders

• Corbin Carroll leads Arizona with 21 hits and an OBP of .391 this season. He has a .288 batting average and a slugging percentage of .575.
• Among qualifying hitters in MLB, he ranks 32nd in batting average, 19th in on-base percentage, and 11th in slugging.
• Ildemaro Vargas leads Arizona in slugging percentage (.623) thanks to nine extra-base hits. He's batting .361 with an on-base percentage of .381.
• Vargas takes a 16-game streak with at least one hit into this one. During his last 10 outings he is hitting .293 with four doubles, two home runs, a walk and seven RBIs.
• Geraldo Perdomo has collected 17 base hits, an OBP of .341 and a slugging percentage of .342 this season.
• Perdomo has recorded at least one base hit in five straight games. During his last five outings he is batting .474 with a double, a triple, two walks and an RBI.
• Ketel Marte has four home runs, nine RBI and a batting average of .218 this season.
• Marte brings a two-game hitting streak into this game. During his last five outings he is hitting .238 with two walks.

White Sox Player Leaders

• Munetaka Murakami has accumulated a team-high OBP (.394), while leading the White Sox in hits (18). He's batting .234 and slugging.
• He is 107th in batting average, 17th in on-base percentage and 10th in slugging percentage among all qualifying hitters in the big leagues.
• Murakami takes a four-game hitting streak into this matchup. In his last five games he is hitting .381 with four home runs, four walks and eight RBIs.
• Miguel Vargas is batting .177 with three doubles, a triple, four home runs and 15 walks. He's slugging .392 with an on-base percentage of .320.
• He is currently 167th in batting average, 110th in on-base percentage and 91st in slugging percentage among all qualifying hitters.
• Colson Montgomery is batting .213 with five doubles, six home runs and nine walks.
• Chase Meidroth leads his team with a .354 slugging percentage.

Diamondbacks vs White Sox Head to Head

• 4/21/2026: 11-5 CHW (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 6/25/2025: 7-3 CHW (Favorite: Diamondbacks, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/24/2025: 4-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/23/2025: 10-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/16/2024: 12-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 6/15/2024: 9-2 CHW (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/14/2024: 7-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/28/2023: 3-1 CHW (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/27/2023: 3-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/26/2023: 15-4 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)

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