Cubs vs Phillies Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 7:12 p.m.

In MLB action on Wednesday, the Chicago Cubs face the Philadelphia Phillies.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Cubs vs Phillies Game Info

• Chicago Cubs (14-9) vs. Philadelphia Phillies (8-15)
• Date: Wednesday, April 22, 2026
• Time: 7:40 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and NBCS-PH+

Cubs vs Phillies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-198) | PHI: (+166)
• Spread: CHC: -1.5 (+106) | PHI: +1.5 (-128)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Cubs vs Phillies Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 1-1, 6.75 ERA vs Kyle Backhus (Phillies) - 0-0, 5.40 ERA

The probable starters are Matthew Boyd (1-1) for the Cubs and Kyle Backhus for the Phillies. Boyd has a record of 1-1-0 ATS in two starts with a spread this season. Boyd's team is 1-1 this season when he starts and they're favored on the moneyline. Backhus' team was never a moneyline underdog a season ago in games he pitched.

Cubs vs Phillies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (63.6%)

Cubs vs Phillies Moneyline

• Chicago is the favorite, -198 on the moneyline, while Philadelphia is a +166 underdog on the road.

Cubs vs Phillies Spread

• The Phillies are at the Cubs, and are +1.5 on the runline. The Phillies are +106 to cover the spread, and the Cubs are -128.

Cubs vs Phillies Over/Under

• The over/under for the Cubs versus Phillies contest on April 22 has been set at 7.5, with -110 odds on the over and -110 odds on the under.

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Cubs vs Phillies Betting Trends

• The Cubs have been favorites in 17 games this season and have come away with the win 10 times (58.8%) in those contests.
• Chicago has a record of 1-2 in contests when bookmakers favor them by -198 or more on the moneyline.
• The Cubs and their opponents have hit the over in 13 of their 23 games with a total set by oddsmakers this season.
• In 23 games with a line this season, the Cubs have a mark of 11-12-0 against the spread.
• The Phillies have yet to win as the moneyline underdog this season, going 4-2.
• Philadelphia has not yet played a game with moneyline odds of +166 or longer.
• The Phillies have played in 23 games with a set over/under, and have combined with their opponents to go over the total 11 times (11-11-1).
• The Phillies have put together a 4-19-0 record against the spread this season (covering just 17.4% of the time).

Cubs Player Leaders

• Nico Hoerner leads Chicago in OBP (.402), slugging percentage (.533) and total hits (30) this season. He has a .326 batting average.
• Among all qualifying hitters in the majors, his batting average ranks sixth, his on-base percentage ranks 14th, and he is 22nd in slugging.
• Hoerner hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .333 with two home runs, a walk and four RBIs.
• Dansby Swanson has a double, five home runs and 18 walks. He's batting .187 and slugging .400 with an on-base percentage of .337.
• His batting average is 160th among qualified players, his on-base percentage 78th, and his slugging percentage 81st.
• Ian Happ has collected 20 base hits, an OBP of .367 and a slugging percentage of .512 this season.
• Happ has logged a hit or more in five straight games. During his last five outings he is batting .375 with two home runs, seven walks and three RBIs.
• Carson Kelly is batting .310 with a .420 OBP and 10 RBI for Chicago this season.

Phillies Player Leaders

• Bryce Harper has a .365 on-base percentage and a .536 slugging percentage, both team-best numbers for the Phillies. He's batting .274.
• Including all the qualifying hitters in the big leagues, he is 48th in batting average, 41st in on-base percentage and 21st in slugging percentage.
• Harper heads into this game on a three-game hitting streak. During his last five outings he is batting .333 with a triple, a home run, two walks and two RBIs.
• Kyle Schwarber has 18 hits to pace his team. He has a batting average of .217 while slugging .554 with an on-base percentage of .363.
• His batting average is 137th among all qualified players, his on-base percentage is 45th, and he is 18th in slugging.
• Trea Turner has four doubles, two home runs and eight walks while hitting .234.
• Brandon Marsh is hitting .276 with four doubles, two home runs and three walks.

Cubs vs Phillies Head to Head

• 4/21/2026: 7-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/20/2026: 5-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/15/2026: 11-2 CHC (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/14/2026: 10-4 CHC (Favorite: Phillies, Spread: -1.5, Total: 10, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/13/2026: 13-7 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/11/2025: 7-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/10/2025: 8-4 CHC (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/9/2025: 4-3 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/27/2025: 3-1 PHI (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/26/2025: 10-4 PHI (Favorite: Phillies, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)

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