Diamondbacks vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 5:12 a.m.

The Arizona Diamondbacks are among the MLB teams in action on Tuesday, up against the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Diamondbacks vs White Sox Game Info

• Arizona Diamondbacks (13-9) vs. Chicago White Sox (8-14)
• Date: Tuesday, April 21, 2026
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: Dbacks.TV and CHSN

Diamondbacks vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-146) | CHW: (+124)
• Spread: ARI: -1.5 (+130) | CHW: +1.5 (-160)
• Total: 9 -- Over: (-115) | Under: (-105)

Diamondbacks vs White Sox Probable Starting Pitchers

Probable Pitchers: Merrill Kelly (Diamondbacks) - 1-0, 3.38 ERA vs Sean Burke (White Sox) - 0-2, 4.43 ERA

The Diamondbacks will look to Merrill Kelly (1-0) against the White Sox and Sean Burke (0-2). Kelly helped his team cover the spread in his only opportunity this season as a starter. This will be Kelly's first game as the moneyline favorite this season. In all of Burke's three starts that had a set spread, the White Sox failed to cover. The White Sox were the underdog on the moneyline for three Burke starts this season -- they lost each time.

Diamondbacks vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (64.1%)

Diamondbacks vs White Sox Moneyline

• Chicago is a +124 underdog on the moneyline, while Arizona is a -146 favorite at home.

Diamondbacks vs White Sox Spread

• The White Sox are +1.5 on the run line against the Diamondbacks. The White Sox are -160 to cover, and the Diamondbacks are +130.

Diamondbacks vs White Sox Over/Under

• The Diamondbacks-White Sox contest on April 21 has been given an over/under of 9 runs. The over is set at -115 and the under at -105.

Bet on Arizona Diamondbacks vs. Chicago White Sox on FanDuel today!

Diamondbacks vs White Sox Betting Trends

• The Diamondbacks have been named as the favorite five times this year and have yet to lose any of those games.
• Arizona has played as a favorite of -146 or more just one time this year and came away with a win in that game.
• Contests with the Diamondbacks have gone over the total set by bookmakers in 13 of 22 chances this season.
• The Diamondbacks are 17-5-0 against the spread in their 22 games that had a posted line this season.
• The White Sox have a 7-14 record in games they were the underdog on the moneyline (winning 33.3% of those games).
• When playing as a moneyline underdog with odds of +124 or longer, Chicago has a 5-9 record (winning just 35.7% of its games).
• The White Sox have played in 21 games with a set over/under, and have combined with their opponents to go over the total 13 times (13-8-0).
• The White Sox have collected a 9-12-0 record against the spread this season (covering 42.9% of the time).

Diamondbacks Player Leaders

• Corbin Carroll has 21 hits and an OBP of .390 to go with a slugging percentage of .600. All three of those stats lead Arizona hitters this season. He has a .300 batting average, as well.
• Among all qualifying hitters, he is 23rd in batting average, his on-base percentage ranks 20th, and he is eighth in slugging.
• Ildemaro Vargas leads Arizona in slugging percentage (.596) thanks to eight extra-base hits. He's batting .368 with an on-base percentage of .390.
• Vargas enters this game looking to extend his 15-game hit streak. During his last 10 outings he is hitting .341 with four doubles, a home run, a walk and four RBIs.
• Ketel Marte has collected 18 base hits, an OBP of .278 and a slugging percentage of .386 this season.
• Geraldo Perdomo has been key for Arizona with 16 hits, an OBP of .325 plus a slugging percentage of .314.
• Perdomo takes a four-game hitting streak into this game. In his last five games he is hitting .421 with a double, a walk and an RBI.

White Sox Player Leaders

• Munetaka Murakami has racked up a team-best OBP (.376), while pacing the White Sox in hits (15). He's batting .208 and slugging.
• Including all qualified hitters, he is 143rd in batting average, while his on-base percentage is 34th and he is 21st in slugging.
• Murakami heads into this matchup on a three-game hitting streak. During his last five outings he is hitting .333 with three home runs, five walks and seven RBIs.
• Miguel Vargas is hitting .173 with three doubles, a triple, three home runs and 14 walks. He's slugging .360 with an on-base percentage of .315.
• He is currently 170th in batting average, 114th in on-base percentage and 117th in slugging percentage among all qualified batters.
• Colson Montgomery has four doubles, five home runs and nine walks while hitting .200.
• Chase Meidroth is slugging .355 to pace his team.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!