Diamondbacks vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 9:11 p.m.

The Tuesday schedule in MLB includes a matchup between the Arizona Diamondbacks and the Chicago White Sox.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Diamondbacks vs White Sox Game Info

• Arizona Diamondbacks (13-9) vs. Chicago White Sox (8-14)
• Date: Tuesday, April 21, 2026
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: Dbacks.TV and CHSN

Diamondbacks vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-144) | CHW: (+122)
• Spread: ARI: -1.5 (+134) | CHW: +1.5 (-162)
• Total: 9 -- Over: (-114) | Under: (-106)

Diamondbacks vs White Sox Probable Starting Pitchers

Probable Pitchers: Merrill Kelly (Diamondbacks) - 1-0, 3.38 ERA vs Sean Burke (White Sox) - 0-2, 4.43 ERA

The Diamondbacks will call on Merrill Kelly (1-0) against the White Sox and Sean Burke (0-2). Kelly helped his team cover the spread in his only opportunity this season as a starter. Kelly has yet to start a game this season when his team was the moneyline favorite. In all of Burke's three starts that had a set spread, the White Sox failed to cover. The White Sox were named the moneyline underdog for three Burke starts this season -- they lost all of the games.

Diamondbacks vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (63.9%)

Diamondbacks vs White Sox Moneyline

• Arizona is the favorite, -144 on the moneyline, while Chicago is a +122 underdog on the road.

Diamondbacks vs White Sox Spread

• The White Sox are at +1.5 on the runline against the Diamondbacks. The White Sox are -162 to cover the spread, and the Diamondbacks are +134.

Diamondbacks vs White Sox Over/Under

• An over/under of 9 has been set for Diamondbacks-White Sox on April 21, with the over being -114 and the under -106.

Bet on Arizona Diamondbacks vs. Chicago White Sox on FanDuel today!

Diamondbacks vs White Sox Betting Trends

• The Diamondbacks have been named as the favorite five times this year and have yet to lose any of those games.
• Arizona has played as a favorite of -144 or more just one time this year and came away with a win in that game.
• The Diamondbacks and their opponents have gone over in 13 of their 22 games with a total set by sportsbooks this season.
• The Diamondbacks have posted a record of 17-5-0 against the spread this season.
• The White Sox have put together a 7-14 record in games they were listed as the moneyline underdog (winning 33.3% of those games).
• Chicago has a 7-10 record (winning 41.2% of its games) when it has played as a moneyline underdog of +122 or longer.
• In the 21 games oddsmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 13 times (13-8-0).
• The White Sox have a 9-12-0 record against the spread this season (covering 42.9% of the time).

Diamondbacks Player Leaders

• Corbin Carroll leads Arizona in OBP (.390), slugging percentage (.600) and total hits (21) this season. He has a .300 batting average.
• Among all qualifying hitters in MLB, his batting average ranks 23rd, his on-base percentage ranks 20th, and he is eighth in slugging.
• Ildemaro Vargas has hit two homers this season while driving in eight runs. He's batting .368 this season and slugging .596 with an on-base percentage of .390.
• Vargas takes a 15-game streak with at least one hit into this contest. During his last 10 outings he is hitting .341 with four doubles, a home run, a walk and four RBIs.
• Ketel Marte has collected 18 base hits, an OBP of .278 and a slugging percentage of .386 this season.
• Geraldo Perdomo is batting .229 with a .325 OBP and five RBI for Arizona this season.
• Perdomo has hit safely in four straight games. During his last five outings he is batting .421 with a double, a walk and an RBI.

White Sox Player Leaders

• Munetaka Murakami has racked up an on-base percentage of .376 and has 15 hits, both team-best marks for the White Sox. He's batting .208 and slugging .542.
• He is 143rd in batting average, 34th in on-base percentage and 21st in slugging percentage among all qualifying batters in MLB.
• Murakami brings a three-game hitting streak into this game. In his last five games he is batting .333 with three home runs, five walks and seven RBIs.
• Miguel Vargas is hitting .173 with three doubles, a triple, three home runs and 14 walks. He's slugging .360 with an on-base percentage of .315.
• Including all qualified hitters, he is 170th in batting average, 114th in on-base percentage and 117th in slugging percentage.
• Colson Montgomery has four doubles, five home runs and nine walks while hitting .200.
• Chase Meidroth leads his team with a .355 slugging percentage.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!