Cubs vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for April 10

Odds updated as of 11:11 p.m.

The Chicago Cubs versus the Pittsburgh Pirates is on the MLB schedule for Friday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Pirates Game Info

• Chicago Cubs (6-6) vs. Pittsburgh Pirates (7-5)
• Date: Friday, April 10, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and SportsNet PT

Cubs vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-148) | PIT: (+126)
• Spread: CHC: -1.5 (+155) | PIT: +1.5 (-188)
• Total: 6.5 -- Over: (-120) | Under: (-102)

Cubs vs Pirates Probable Starting Pitchers

Probable Pitchers: Shota Imanaga (Cubs) - 0-1, 4.50 ERA vs Carmen Mlodzinski (Pirates) - 0-0, 4.00 ERA

The Cubs will give the nod to Shota Imanaga (0-1) against the Pirates and Carmen Mlodzinski. Imanaga has a record of 0-2-0 ATS in two starts with a spread this season. Imanaga's team is 0-2 this season when he starts and they're favored on the moneyline. Mlodzinski has started two games with set spreads, and the Pirates covered in both opportunities. The Pirates were named the moneyline underdog for one Mlodzinski start this season -- they won.

Cubs vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (54.8%)

Cubs vs Pirates Moneyline

• Pittsburgh is a +126 underdog on the moneyline, while Chicago is a -148 favorite at home.

Cubs vs Pirates Spread

• The Cubs are 1.5-run home favorites on the runline against the Pirates. The Cubs are +155 to cover, and the Pirates are -188.

Cubs vs Pirates Over/Under

• A combined run total of 6.5 has been set for Cubs-Pirates on April 10, with the over at -120 and the under at -102.

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Cubs vs Pirates Betting Trends

• The Cubs have been favorites in nine games this season and have come away with the win four times (44.4%) in those contests.
• This year Chicago has won three of five games when listed as at least -148 on the moneyline.
• The Cubs and their opponents have gone over the total this season in six of their 12 opportunities.
• The Cubs have an against the spread record of 5-7-0 in 12 games with a line this season.
• The Pirates have gone 2-4 in games they were listed as the moneyline underdog (winning 33.3% of those games).
• Pittsburgh has played as a moneyline underdog of +126 or longer in just two games this season, which it split 1-1.
• The Pirates have played in 12 games with a set over/under, and have combined with their opponents to go over the total seven times (7-5-0).
• The Pirates have collected a 7-5-0 record against the spread this season (covering 58.3% of the time).

Cubs Player Leaders

• Nico Hoerner leads Chicago with an OBP of .453, plus a team-best slugging percentage of .548. He's batting .333 on the season.
• Among all qualifying batters, he is 15th in batting average, his on-base percentage ranks eighth, and he is 30th in slugging.
• Hoerner has recorded at least one hit in four straight games. In his last five games he is hitting .389 with two doubles, a home run, three walks and six RBIs.
• Ian Happ has eight hits, which is tops among Chicago batters this season. He's batting .200 with six extra-base hits. He's also slugging .550 with an on-base percentage of .289.
• Among all qualifying players, he ranks 128th in batting average, 126th in on-base percentage and 29th in slugging percentage.
• Happ enters this matchup looking to extend his two-game hit streak. During his last five outings he is hitting .190 with two doubles, a home run, a walk and two RBIs.
• Matt Shaw has nine hits this season and has a slash line of .257/.289/.457.
• Shaw has logged a hit or more in four straight games. In his last five games he is batting .294 with a double, two home runs, two walks and three RBIs.
• Pete Crow-Armstrong has been key for Chicago with 11 hits, an OBP of .265 plus a slugging percentage of .319.

Pirates Player Leaders

• Ryan O'Hearn has racked up an on-base percentage of .449, a slugging percentage of .625, and has 14 hits, all club-bests for the Pirates (while batting .350).
• Including all the qualified hitters in the big leagues, his batting average ranks 10th, his on-base percentage is 10th, and he is 12th in slugging.
• Oneil Cruz is slugging .583 to pace his team. He has a batting average of .292 with an on-base percentage of .333.
• Including all qualifying hitters, he ranks 39th in batting average, 76th in on-base percentage and 17th in slugging percentage.
• Bryan Reynolds is hitting .244 with a double, two home runs and eight walks.
• Brandon Lowe has two doubles, three home runs and seven walks while batting .220.

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