Cubs vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for NL Wild Card Game 1 on Sept. 30

Odds updated as of 10:12 p.m.

The Tuesday slate in the MLB includes a matchup between the Chicago Cubs and the San Diego Padres in Game 1 of the NL Wild Card Series.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

Cubs vs Padres Game Info

• Chicago Cubs (92-70) vs. San Diego Padres (90-72)
• Date: Tuesday, September 30, 2025
• Time: 3:08 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: ABC

Cubs vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-116) | SD: (-102)
• Spread: CHC: +1.5 (-220) | SD: -1.5 (+180)
• Total: 7 -- Over: (-114) | Under: (-106)

Cubs vs Padres Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 14-8, 3.21 ERA vs Nick Pivetta (Padres) - 13-5, 2.87 ERA

The Cubs will look to Matthew Boyd (14-8, 3.21 ERA) versus the Padres and Nick Pivetta (13-5, 2.87 ERA). Boyd and his team have a record of 13-17-0 against the spread when he starts. Boyd's team is 14-10 this season when he starts and they are the moneyline favorite. The Padres have gone 18-13-0 ATS in Pivetta's 31 starts with a set spread. The Padres have a 7-3 record in Pivetta's 10 starts this season when they were the underdog on the moneyline.

Cubs vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (50.7%)

Cubs vs Padres Moneyline

• The moneyline numbers for Cubs vs. Padres reveal Chicago as the favorite (-116) and San Diego as the underdog (-102) on the road.

Cubs vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Cubs. The Padres are +180 to cover, while the Cubs are -220 to cover as a 1.5-run underdog on the runline.

Cubs vs Padres Over/Under

• Cubs versus Padres on Sept. 30 has an over/under of 7 runs, with the odds on the over -114 and the under set at -106.

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Cubs vs Padres Betting Trends

• The Cubs have been chosen as favorites in 108 games this year and have walked away with the win 70 times (64.8%) in those games.
• This year Chicago has won 69 of 105 games when listed as at least -116 on the moneyline.
• The Cubs and their opponents have hit the over in 74 of their 157 games with a total set by oddsmakers this season.
• The Cubs have an against the spread mark of 75-82-0 in 157 games with a line this season.
• The Padres have won 49.3% of the games this season they were the moneyline underdog (33-34).
• San Diego is 30-33 (winning 47.6% of its games) when playing as a moneyline underdog of -102 or longer.
• The Padres have combined with opponents to go over the total 70 times this season for a 70-87-3 record against the over/under.
• The Padres have collected an 87-73-0 record against the spread this season.

Cubs Player Leaders

• Kyle Tucker leads Chicago in OBP (.377) this season, fueled by 133 hits. He has a .266 batting average and a slugging percentage of .464.
• Among qualifying hitters in baseball, his batting average ranks 46th, his on-base percentage ranks seventh, and he is 44th in slugging.
• Nico Hoerner has an OPS of .739, fueled by an OBP of .345 and a team-best slugging percentage of .394 this season. He's batting .297.
• Among all qualified, he is eighth in batting average, 46th in on-base percentage and 110th in slugging percentage.
• Pete Crow-Armstrong is batting .247 with a .481 slugging percentage and 95 RBI this year.
• Crow-Armstrong heads into this game with four games in a row with at least one hit. During his last five outings he is batting .294 with two home runs and five RBIs.
• Seiya Suzuki has 32 home runs, 103 RBI and a batting average of .245 this season.
• Suzuki heads into this game on a seven-game hitting streak. During his last 10 outings he is hitting .281 with two doubles, five home runs, four walks and 12 RBIs.

Padres Player Leaders

• Fernando Tatis Jr. a has .368 on-base percentage to pace the Padres. He's batting .268 while slugging .446.
• He ranks 43rd in batting average, 10th in on-base percentage and 60th in slugging percentage among all qualified hitters in the big leagues.
• Tatis brings an eight-game hitting streak into this game. In his last 10 outings he is hitting .368 with three home runs, four walks and six RBIs.
• Manny Machado paces his team with 169 hits. He has a batting average of .275 while slugging .460 with an on-base percentage of .335.
• His batting average is 33rd among all qualified players, his on-base percentage is 58th, and he is 49th in slugging.
• Luis Arraez has a .392 slugging percentage, which leads the Padres.
• Ryan O'Hearn has 21 doubles, a triple, 17 home runs and 58 walks while batting .281.

Cubs vs Padres Head to Head

• 4/16/2025: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/15/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/14/2025: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/6/2025: 8-7 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/4/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/8/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/7/2024: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/6/2024: 6-3 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/10/2024: 10-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)

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