Cubs vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 27

Odds updated as of 5:11 a.m.

The Chicago Cubs will face the San Diego Padres in MLB action on Monday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Padres Game Info

• Chicago Cubs (17-11) vs. San Diego Padres (18-9)
• Date: Monday, April 27, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and MARQ

Cubs vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-116) | SD: (-102)
• Spread: CHC: -1.5 (+146) | SD: +1.5 (-178)
• Total: 8 -- Over: (-110) | Under: (-110)

Cubs vs Padres Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 1-1, 5.79 ERA vs Randy Vasquez (Padres) - 2-0, 1.88 ERA

This contest's pitching matchup is set, as the Cubs will send Matthew Boyd (1-1) to the mound, while Randy Vasquez (2-0) will take the ball for the Padres. Boyd and his team have a record of 2-1-0 against the spread when he starts. Boyd's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 2-1. The Padres have a 4-1-0 record against the spread in Vasquez's starts. The Padres were named the moneyline underdog for one Vasquez start this season -- they won.

Cubs vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (54.6%)

Cubs vs Padres Moneyline

• Looking at the moneyline for Padres-Cubs, San Diego is the underdog at -102, and Chicago is -116 playing on the road.

Cubs vs Padres Spread

• The Cubs are at the Padres and are favored by 1.5 runs on the spread. The Cubs are +146 to cover the runline, with the Padres being -178.

Cubs vs Padres Over/Under

• A combined run total of 8 has been set for Cubs-Padres on April 27, with the over at -110 and the under at -110.

Bet on Chicago Cubs vs. San Diego Padres on FanDuel today!

Cubs vs Padres Betting Trends

• The Cubs have won in 11, or 61.1%, of the 18 contests they have been named as odds-on favorites in this year.
• Chicago has a record of 10-7 when favored by -116 or more this year.
• Contests with the Cubs have gone over the total set by sportsbooks in 17 of 28 chances this season.
• In 28 games with a line this season, the Cubs have a mark of 14-14-0 against the spread.
• The Padres are 6-5 in games they were listed as the moneyline underdog (winning 54.5% of those games).
• When playing as a moneyline underdog with odds of -102 or longer, San Diego has a 5-5 record (winning 50% of its games).
• The Padres have played in 27 games with an over/under set, and have combined with opponents to go over the total 11 times (11-15-1).
• The Padres have put together a 17-10-0 record against the spread this season (covering 63% of the time).

Cubs Player Leaders

• Nico Hoerner leads Chicago with an OBP of .382, plus a team-best slugging percentage of .474. He's batting .307 on the season.
• Among qualifying hitters in MLB, his batting average ranks 21st, his on-base percentage ranks 22nd, and he is 42nd in slugging.
• Hoerner hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .227 with two walks and an RBI.
• Dansby Swanson has a double, a triple, six home runs and 19 walks. He's batting .191 and slugging .415 with an on-base percentage of .325.
• Among qualifying hitters, his batting average ranks him 164th, his on-base percentage 103rd, and his slugging percentage 80th.
• Ian Happ has 24 hits and is batting .235 this season.
• Moises Ballesteros is batting .397 with a .446 OBP and 12 RBI for Chicago this season.
• Ballesteros takes a four-game hitting streak into this matchup. During his last five outings he is hitting .462 with four doubles, a home run, two walks and two RBIs.

Padres Player Leaders

• Xander Bogaerts has accumulated an on-base percentage of .358 and a slugging percentage of .423. Both lead the Padres. He's batting .278.
• Including all qualified players in the big leagues, he ranks 42nd in batting average, 45th in on-base percentage and 73rd in slugging percentage.
• Manny Machado has two doubles, four home runs and 17 walks while batting .209. He's slugging .363 with an on-base percentage of .327.
• Including all qualified players, he ranks 145th in batting average, 95th in on-base percentage and 124th in slugging percentage.
• Ramon Laureano has racked up 25 hits, a team-best for the Padres.
• Jackson Merrill is batting .214 with six doubles, three home runs and nine walks.

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