Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for June 26

Odds updated as of 1:11 a.m.

The MLB's Thursday slate includes the Chicago Cubs facing the St. Louis Cardinals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Cardinals Game Info

• Chicago Cubs (47-33) vs. St. Louis Cardinals (44-37)
• Date: Thursday, June 26, 2025
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and MARQ

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-136) | STL: (+116)
• Spread: CHC: -1.5 (+118) | STL: +1.5 (-142)
• Total: 9 -- Over: (-110) | Under: (-110)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Shota Imanaga (Cubs) - 3-2, 2.82 ERA vs Andre Pallante (Cardinals) - 5-3, 4.48 ERA

The Cubs will give the nod to Shota Imanaga (3-2) against the Cardinals and Andre Pallante (5-3). When Imanaga starts, his team is 4-4-0 against the spread this season. Imanaga's team has a record of 3-1 this season when he starts and they are the favorite on the moneyline. The Cardinals are 10-5-0 against the spread when Pallante starts. The Cardinals have a 6-3 record in Pallante's nine starts this season when they were the underdog on the moneyline.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (50.6%)

Cubs vs Cardinals Moneyline

• Chicago is a -136 favorite on the moneyline, while St. Louis is a +116 underdog at home.

Cubs vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Cubs. The Cardinals are -142 to cover, and the Cubs are +118.

Cubs vs Cardinals Over/Under

• The over/under for the Cubs versus Cardinals contest on June 26 has been set at 9, with -110 odds on the over and -110 odds on the under.

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Cubs vs Cardinals Betting Trends

• The Cubs have won in 36, or 69.2%, of the 52 contests they have been named as odds-on favorites in this year.
• This season Chicago has been victorious 26 times in 36 chances when named as a favorite of at least -136 on the moneyline.
• Contests with the Cubs have gone over the total set by sportsbooks in 42 of 78 chances this season.
• The Cubs are 39-39-0 against the spread in their 78 games with a line set by sportsbooks this season.
• The Cardinals have been the moneyline underdog 45 total times this season. They've finished 24-21 in those games.
• St. Louis has a 9-11 record (winning 45% of its games) when it has played as a moneyline underdog of +116 or longer.
• The Cardinals have had an over/under set by bookmakers 81 times, and have combined with opponents to go over the total in 43 of those games (43-35-3).
• The Cardinals have collected a 44-37-0 record ATS this season.

Cubs Player Leaders

• Kyle Tucker has an OPS of .933, fueled by an OBP of .399 to go with a slugging percentage of .534. He has a .291 batting average, as well.
• Among all qualified hitters in the majors, his batting average ranks 23rd, his on-base percentage ranks fourth, and he is 13th in slugging.
• Tucker will look for his third straight game with a hit in this matchup. In his last five games he is batting .381 with three home runs, three walks and six RBIs.
• Pete Crow-Armstrong leads Chicago with 84 hits. He is batting .272 this season and has 44 extra-base hits. He's also slugging .560 with an on-base percentage of .308.
• Among all qualified batters, he ranks 51st in batting average, 117th in on-base percentage and sixth in slugging percentage.
• Crow-Armstrong enters this game looking to extend his five-game hit streak. In his last five games he is hitting .350 with four doubles, a home run and an RBI.
• Seiya Suzuki is batting .258 with a .539 slugging percentage and 67 RBI this year.
• Nico Hoerner has an OPS of .703, fueled by an OBP of .334 and a team-best slugging percentage of .369 this season.
• Hoerner has hit safely in four straight games. During his last five outings he is hitting .389 with a home run and three RBIs.

Cardinals Player Leaders

• Brendan Donovan has a .372 on-base percentage and a .432 slugging percentage, both team-best numbers for the Cardinals. He's batting .305.
• Including all the qualified hitters in the majors, his batting average puts him 13th, his on-base percentage ranks 22nd, and he is 69th in slugging.
• Nolan Arenado is batting .245 with 11 doubles, a triple, 10 home runs and 23 walks. He's slugging .395 with an on-base percentage of .306.
• Including all qualified hitters, he ranks 111th in batting average, 121st in on-base percentage and 112th in slugging percentage.
• Lars Nootbaar is hitting .230 with 13 doubles, 11 home runs and 44 walks.
• Masyn Winn is hitting .257 with 14 doubles, seven home runs and 24 walks.

Cubs vs Cardinals Head to Head

• 6/25/2025: 8-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/24/2025: 8-7 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/23/2025: 8-2 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/4/2024: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/3/2024: 5-4 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/2/2024: 6-3 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/1/2024: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/14/2024: 8-3 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/13/2024: 5-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/13/2024: 11-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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