Cardinals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 7:12 p.m.

MLB action on Saturday includes the St. Louis Cardinals facing the Chicago White Sox.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Cardinals vs White Sox Game Info

• St. Louis Cardinals (73-75) vs. Chicago White Sox (75-72)
• Date: Saturday, September 12, 2026
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and CHSN

Cardinals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-110) | CHW: (-106)
• Spread: STL: +1.5 (-192) | CHW: -1.5 (+158)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Cardinals vs White Sox Probable Starting Pitchers

Probable Pitchers: Kyle Leahy (Cardinals) - 10-4, 3.41 ERA vs Sean Newcomb (White Sox) - 2-4, 2.71 ERA

This contest's pitching matchup is set, as the Cardinals will send Kyle Leahy (10-4) to the mound, while Sean Newcomb (2-4) will answer the bell for the White Sox. When Leahy starts, his team is 12-13-0 against the spread this season. Leahy's team has won 50% of his starts when they are favored on the moneyline (5-5). The White Sox have a 3-1-0 ATS record in Newcomb's four starts with a set spread. The White Sox have been the moneyline underdog in three of Newcomb's starts this season, and they went 2-1 in those games.

Cardinals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.8%)

Cardinals vs White Sox Moneyline

• Looking at the moneyline for Cardinals-White Sox, St. Louis is the favorite at -110, and Chicago is -106 playing on the road.

Cardinals vs White Sox Spread

• The White Sox are 1.5-run favorites against the spread for this matchup with the Cardinals. The White Sox are +158 to cover, while the Cardinals are -192 to cover as a 1.5-run underdog on the runline.

Cardinals vs White Sox Over/Under

• The Cardinals-White Sox contest on Sept. 12 has been given an over/under of 7.5 runs. The over is set at -120 and the under at -102.

Bet on St. Louis Cardinals vs. Chicago White Sox on FanDuel today!

Cardinals vs White Sox Betting Trends

• The Cardinals have been victorious in 26, or 54.2%, of the 48 contests they have been chosen as favorites in this season.
• This year St. Louis has won 25 of 47 games when listed as at least -110 on the moneyline.
• The Cardinals and their opponents have gone over the total this season in 66 of their 144 opportunities.
• The Cardinals have an against the spread record of 78-66-0 in 144 games with a line this season.
• The White Sox have been the underdog on the moneyline 102 total times this season. They've finished 49-53 in those games.
• Chicago is 48-53 (winning 47.5% of its games) when it has played as a moneyline underdog of -106 or longer.
• The White Sox have had an over/under set by oddsmakers 144 times, and have combined with opponents to go over the total in 79 of those games (79-64-1).
• The White Sox have an 81-63-0 record against the spread this season (covering 56.2% of the time).

Cardinals Player Leaders

• Alec Burleson leads St. Louis in slugging percentage (.469) thanks to 58 extra-base hits. He has a .284 batting average and an on-base percentage of .350.
• Among qualified hitters, he is 15th in batting average, his on-base percentage ranks 43rd, and he is 33rd in slugging.
• Jordan Walker leads St. Louis in slugging percentage (.491) and total hits (159) this season. He's batting .283 with an on-base percentage of .338.
• His batting average is 17th among qualified players, his on-base percentage 56th, and his slugging percentage 21st.
• Ivan Herrera has 138 hits this season and a team-best OBP of .359.
• Nathan Church has been key for St. Louis with 95 hits, an OBP of .292 plus a slugging percentage of .364.
• Church has safely hit in 10 games in a row. During his last 10 games he is batting .314 with a double, three walks and three RBIs.

White Sox Player Leaders

• Miguel Vargas has 133 hits, a team-high for the White Sox. He's batting .247 and slugging .474 with an on-base percentage of .357.
• He is 82nd in batting average, 34th in on-base percentage and 28th in slugging percentage among all qualified hitters in the big leagues.
• Chase Meidroth is slugging .402 to lead his team. He has a batting average of .269 with an on-base percentage of .345.
• Including all qualified hitters, he is 45th in batting average, 48th in on-base percentage and 89th in slugging percentage.
• Sam Antonacci has put up an on-base percentage of .365, a team-best for the White Sox.
• Tristan Peters is batting .279 with 30 doubles, four triples, 12 home runs and 34 walks.

Cardinals vs White Sox Head to Head

• 9/11/2026: 7-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/19/2025: 8-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 6/19/2025: 5-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/17/2025: 12-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/5/2024: 5-1 CHW (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/4/2024: 6-5 CHW (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/3/2024: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 7/9/2023: 4-3 STL (Favorite: White Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2023: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 10, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2023: 8-7 CHW (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)

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