Rays vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 12:12 a.m.

Saturday's slate in the MLB includes a matchup between the Tampa Bay Rays and the Houston Astros.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

Rays vs Astros Game Info

• Tampa Bay Rays (88-59) vs. Houston Astros (75-73)
• Date: Saturday, September 12, 2026
• Time: 6:10 p.m. ET
• Venue: Tropicana Field -- St. Petersburg, Florida
• Coverage: Rays.TV and SCHN

Rays vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-144) | HOU: (+122)
• Spread: TB: -1.5 (+138) | HOU: +1.5 (-166)
• Total: 7.5 -- Over: (-128) | Under: (+104)

Rays vs Astros Probable Starting Pitchers

Probable Pitchers: Ian Seymour (Rays) - 9-6, 4.33 ERA vs Peter Lambert (Astros) - 8-8, 3.67 ERA

The Rays will give the ball to Ian Seymour (9-6, 4.33 ERA), who is eyeing win No. 10 on the season, and the Astros will turn to Peter Lambert (8-8, 3.67 ERA). Seymour and his team are 7-5-0 ATS this season when he starts. Seymour's team is 4-6 this season when he starts and they are the moneyline favorite. The Astros have a 15-10-0 ATS record in Lambert's 25 starts with a set spread. The Astros have been the moneyline underdog in 12 of Lambert's starts this season, and they went 6-6 in those matchups.

Rays vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (61.8%)

Rays vs Astros Moneyline

• Houston is the underdog, +122 on the moneyline, while Tampa Bay is a -144 favorite at home.

Rays vs Astros Spread

• The Rays are hosting the Astros and are favored by 1.5 runs (+138 to cover) on the runline. Houston is -166 to cover.

Rays vs Astros Over/Under

• An over/under of 7.5 has been set for Rays-Astros on Sept. 12, with the over being -128 and the under +104.

Bet on Tampa Bay Rays vs. Houston Astros on FanDuel today!

Rays vs Astros Betting Trends

• The Rays have been favorites in 96 games this season and have come away with the win 59 times (61.5%) in those contests.
• This season Tampa Bay has been victorious 23 times in 35 chances when named as a favorite of at least -144 on the moneyline.
• The Rays and their opponents have gone over in 69 of their 145 games with a total set by sportsbooks this season.
• The Rays are 79-66-0 against the spread in their 145 games with a line set by sportsbooks this season.
• The Astros have won 40 of the 78 games they were the underdog on the moneyline this season (51.3%).
• Houston is 12-16 (winning 42.9% of its games) when playing as a moneyline underdog of +122 or longer.
• The Astros have played in 148 games with a set over/under, and have combined with opponents to go over the total 74 times (74-67-7).
• The Astros have covered 50% of their games this season, going 74-74-0 ATS.

Rays Player Leaders

• Junior Caminero leads Tampa Bay with 157 hits, batting .279 this season with 62 extra-base hits. He has an on-base percentage of .365 and a slugging percentage of .534.
• Among all qualified hitters in MLB, his batting average ranks 26th, his on-base percentage ranks 21st, and he is fourth in slugging.
• Yandy Diaz leads the Rays with an OPS of .835. He has a slash line of .303/.368/.467 this season.
• Among qualified batters, his batting average places him sixth, his on-base percentage 18th, and his slugging percentage 33rd.
• Liam Hicks has 127 hits this season and a team-best OBP of .368.
• Jonathan Aranda is batting .276 with a .359 OBP and 86 RBI for Tampa Bay this season.

Astros Player Leaders

• Yordan Alvarez has accumulated a team-best OBP (.427) and slugging percentage (.590), and leads the Astros in hits (162, while batting .310).
• He ranks second in batting average, first in on-base percentage and first in slugging percentage among all qualified hitters in the majors.
• Isaac Paredes has 26 doubles, a triple, 19 home runs and 63 walks while batting .260. He's slugging .426 with an on-base percentage of .359.
• Including all qualifying hitters, his batting average puts him 62nd, his on-base percentage is 32nd, and he is 68th in slugging.
• Christian Walker is hitting .227 with 25 doubles, a triple, 25 home runs and 46 walks.
• Jose Altuve is hitting .246 with 22 doubles, two triples, 15 home runs and 39 walks.

Rays vs Astros Head to Head

• 9/11/2026: 3-1 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 7/5/2026: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/4/2026: 10-8 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/3/2026: 3-1 TB (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/1/2025: 1-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/31/2025: 16-3 TB (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/30/2025: 2-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/29/2025: 13-3 TB (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/21/2025: 8-4 TB (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/20/2025: 3-2 TB (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)

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