Padres vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 3:12 p.m.

MLB action on Saturday includes the San Diego Padres taking on the San Francisco Giants.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Giants Game Info

• San Diego Padres (79-68) vs. San Francisco Giants (62-86)
• Date: Saturday, September 12, 2026
• Time: 4:05 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Padres.TV

Padres vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-156) | SF: (+132)
• Spread: SD: -1.5 (+114) | SF: +1.5 (-134)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Padres vs Giants Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 10-9, 3.00 ERA vs César Perdomo (Giants) - 0-0, 0.90 ERA

The Padres will give the nod to Michael King (10-9, 3.00 ERA), who is eyeing win No. 11 on the season, and the Giants will turn to Cesar Perdomo. King and his team have a record of 11-18-0 against the spread when he starts. King's team has won 47.4% of his starts when they are favored on the moneyline (9-10). Perdomo has started only one game with a set spread, which the Giants failed to cover. The Giants were named the moneyline underdog for one Perdomo start this season -- they lost.

Padres vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (52.1%)

Padres vs Giants Moneyline

• San Francisco is the underdog, +132 on the moneyline, while San Diego is a -156 favorite despite being on the road.

Padres vs Giants Spread

• The Padres are at the Giants and are favored by 1.5 runs on the spread. The Padres are +114 to cover the runline, with the Giants being -134.

Padres vs Giants Over/Under

• An over/under of 7.5 has been set for Padres-Giants on Sept. 12, with the over being -115 and the under -105.

Bet on San Diego Padres vs. San Francisco Giants on FanDuel today!

Padres vs Giants Betting Trends

• The Padres have been victorious in 40, or 58%, of the 69 contests they have been chosen as favorites in this season.
• San Diego has a record of 13-7 when favored by -156 or more this year.
• The Padres' games have gone over the total in 65 of their 147 opportunities.
• The Padres have an against the spread mark of 85-62-0 in 147 games with a line this season.
• The Giants are 37-62 in games they were the underdog on the moneyline (winning 37.4% of those games).
• When playing as a moneyline underdog with odds of +132 or longer, San Francisco has gone 14-19 (42.4%).
• The Giants have had an over/under set by bookmakers 145 times, and have combined with opponents to go over the total in 70 of those games (70-65-10).
• The Giants have collected a 69-76-0 record against the spread this season (covering 47.6% of the time).

Padres Player Leaders

• Fernando Tatis Jr. has 162 hits and an OBP of .351 to go with a slugging percentage of .451. All three of those stats are tops among San Diego hitters this season. He has a .284 batting average, as well.
• Among qualifying hitters in the majors, he is 15th in batting average, 41st in on-base percentage, and 45th in slugging.
• Tatis will look for his third straight game with a hit in this contest. In his last five games he is batting .400 with a triple, a home run, two walks and two RBIs.
• Manny Machado is batting .222 with 22 doubles, 26 home runs and 71 walks. He's slugging .411 with an on-base percentage of .311.
• He ranks 122nd in batting average, 98th in on-base percentage and 80th in slugging among qualified hitters.
• Jackson Merrill is batting .248 with a .434 slugging percentage and 79 RBI this year.
• Merrill heads into this game with two games in a row with at least one hit. During his last five outings he is hitting .500 with two doubles, a triple, two home runs and nine RBIs.
• Xander Bogaerts has been key for San Diego with 104 hits, an OBP of .319 plus a slugging percentage of .319.
• Bogaerts has safely hit in two games in a row. In his last five games he is batting .176 with a double, three walks and two RBIs.

Giants Player Leaders

• Rafael Devers has accumulated an on-base percentage of .340, a slugging percentage of .522, and has 143 hits, all club-highs for the Giants (while batting .258).
• Including all qualified players in the big leagues, he is 66th in batting average, 54th in on-base percentage and seventh in slugging percentage.
• Jung Hoo Lee is hitting .279 with 29 doubles, four triples, nine home runs and 27 walks. He's slugging .405 with an on-base percentage of .322.
• Including all qualified hitters, he ranks 25th in batting average, 82nd in on-base percentage and 87th in slugging percentage.
• Bryce Eldridge is batting .270 with 22 doubles, 16 home runs and 55 walks.
• Drew Gilbert has 14 doubles, three triples, eight home runs and 34 walks while hitting .232.

Padres vs Giants Head to Head

• 9/11/2026: 7-5 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 8/2/2026: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +110)
• 8/1/2026: 6-5 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +134)
• 7/31/2026: 7-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +132)
• 7/30/2026: 4-1 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/6/2026: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: -106)
• 5/5/2026: 10-5 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/4/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -194, Underdog Moneyline: +150)
• 4/1/2026: 7-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 3/31/2026: 9-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)

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