Cardinals vs Tigers Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 1:13 p.m.

The St. Louis Cardinals versus the Detroit Tigers is on the MLB schedule for Wednesday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Tigers Game Info

• St. Louis Cardinals (27-22) vs. Detroit Tigers (32-17)
• Date: Wednesday, May 21, 2025
• Time: 1:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSDET

Cardinals vs Tigers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-116) | DET: (-102)
• Spread: STL: +1.5 (-200) | DET: -1.5 (+164)
• Total: 9 -- Over: (-100) | Under: (-122)

Cardinals vs Tigers Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 4-2, 4.11 ERA vs Brant Hurter (Tigers) - 1-0, 2.35 ERA

The Cardinals will call on Andre Pallante (4-2) against the Tigers and Brant Hurter (1-0). Pallante's team is 6-3-0 against the spread in his starts this season. Pallante's team won his only start as a favorite this season. Last season Hurter pitched in one game with a spread, which his team covered. Hurter did not pitch as a moneyline underdog a season ago.

Cardinals vs Tigers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (50.9%)

Cardinals vs Tigers Moneyline

• The Cardinals vs Tigers moneyline has St. Louis as a -116 favorite, while Detroit is a -102 underdog on the road.

Cardinals vs Tigers Spread

• The Tigers are 1.5-run favorites against the spread for this matchup with the Cardinals. The Tigers are +164 to cover, while the Cardinals are -200 to cover as a 1.5-run underdog on the runline.

Cardinals vs Tigers Over/Under

• A combined run total of 9 has been set for Cardinals-Tigers on May 21, with the over at -100 and the under at -122.

Bet on St. Louis Cardinals vs. Detroit Tigers on FanDuel today!

Cardinals vs Tigers Betting Trends

• The Cardinals have been chosen as favorites in 15 games this year and have walked away with the win eight times (53.3%) in those games.
• This season St. Louis has come away with a win six times in 11 chances when named as a favorite of at least -116 on the moneyline.
• Contests with the Cardinals have gone over the total set by sportsbooks in 26 of 49 chances this season.
• In 49 games with a line this season, the Cardinals have a mark of 28-21-0 against the spread.
• The Tigers have won nine of the 19 games they were the underdog on the moneyline this season (47.4%).
• Detroit is 7-9 (winning 43.8% of its games) when playing as a moneyline underdog of -102 or longer.
• The Tigers have combined with opponents to hit the over on the total 25 times this season for a 25-20-3 record against the over/under.
• The Tigers have put together a 26-22-0 record ATS this season (covering 54.2% of the time).

Cardinals Player Leaders

• Lars Nootbaar is hitting .251 with 10 doubles, seven home runs and 31 walks. He has an on-base percentage of .356 while slugging .414.
• Among qualified hitters in MLB, his batting average ranks 90th, his on-base percentage ranks 53rd, and he is 84th in slugging.
• Brendan Donovan has 61 hits and an OBP of .384 to go with a slugging percentage of .465. All three of those stats are best among St. Louis hitters this season. He's batting .330.
• His batting average ranks sixth among qualified players, his on-base percentage 17th, and his slugging percentage 46th.
• Nolan Arenado has 43 hits this season and has a slash line of .247/.320/.391.
• Willson Contreras is batting .249 with a .328 OBP and 27 RBI for St. Louis this season.
• Contreras brings a two-game hitting streak into this game. During his last five outings he is hitting .190 with two doubles and two RBIs.

Tigers Player Leaders

• Spencer Torkelson is batting .240 with 12 doubles, 12 home runs and 25 walks. He's slugging .520 with an on-base percentage of .345.
• Including all qualified hitters, he is 106th in batting average, while his on-base percentage is 63rd and he is 20th in slugging.
• Riley Greene paces his team with 53 hits and has a club-best .535 slugging percentage. He has a batting average of .286 with an on-base percentage of .337.
• Including all qualifying hitters, he is 35th in batting average, 67th in on-base percentage and 15th in slugging percentage.
• Gleyber Torres has six doubles, five home runs and 16 walks while batting .283.
• Kerry Carpenter has six doubles, a triple, 10 home runs and five walks while hitting .283.

Cardinals vs Tigers Head to Head

• 5/20/2025: 5-4 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 5/19/2025: 11-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/1/2024: 4-1 DET (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/30/2024: 11-6 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2024: 2-1 STL (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/7/2023: 12-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 5/6/2023: 6-5 DET (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 5/5/2023: 5-4 DET (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -240, Underdog Moneyline: +198)

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