Cardinals vs Tigers Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 4:14 a.m.

In MLB action on Wednesday, the St. Louis Cardinals play the Detroit Tigers.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Tigers Game Info

• St. Louis Cardinals (27-22) vs. Detroit Tigers (32-17)
• Date: Wednesday, May 21, 2025
• Time: 1:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSDET

Cardinals vs Tigers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-112) | DET: (-104)
• Spread: STL: +1.5 (-200) | DET: -1.5 (+164)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Cardinals vs Tigers Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 4-2, 4.11 ERA vs Brant Hurter (Tigers) - 1-0, 2.35 ERA

The Cardinals will give the nod to Andre Pallante (4-2, 4.11 ERA), who is eyeing win No. 5 on the season, and the Tigers will counter with Brant Hurter (1-0, 2.35 ERA). Pallante and his team are 6-3-0 ATS this season when he starts. Pallante's team won his only start as a favorite this season. Last season Hurter pitched in one game with a spread, which his team covered. Hurter did not pitch as a moneyline underdog a season ago.

Cardinals vs Tigers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (58.1%)

Cardinals vs Tigers Moneyline

• St. Louis is a -112 favorite on the moneyline, while Detroit is a -104 underdog on the road.

Cardinals vs Tigers Spread

• The Tigers are 1.5-run favorites against the spread for this matchup with the Cardinals. The Tigers are +164 to cover, while the Cardinals are -200 to cover as a 1.5-run underdog on the runline.

Cardinals vs Tigers Over/Under

• The over/under for Cardinals-Tigers on May 21 is 8.5. The over is -115, and the under is -105.

Bet on St. Louis Cardinals vs. Detroit Tigers on FanDuel today!

Cardinals vs Tigers Betting Trends

• The Cardinals have been chosen as favorites in 15 games this year and have walked away with the win eight times (53.3%) in those games.
• St. Louis has a record of 7-5 in contests when bookmakers favor them by -112 or more on the moneyline.
• The Cardinals and their opponents have hit the over in 26 of their 49 games with a total set by oddsmakers this season.
• In 49 games with a line this season, the Cardinals have a mark of 28-21-0 against the spread.
• The Tigers have won 47.4% of the games this season they were the moneyline underdog (9-10).
• In games it has played as a moneyline underdog with odds of -104 or longer, Detroit has a record of 9-10 (47.4%).
• The Tigers have played in 48 games with a set over/under, and have combined with opponents to go over the total 25 times (25-20-3).
• The Tigers have collected a 26-22-0 record against the spread this season (covering 54.2% of the time).

Cardinals Player Leaders

• Lars Nootbaar is hitting .251 with 10 doubles, seven home runs and 31 walks. He has an on-base percentage of .356 and a slugging percentage of .414.
• He ranks 90th in batting average, 53rd in on-base percentage, and 84th in slugging among qualified hitters in the majors.
• Brendan Donovan has 61 hits and an OBP of .384 to go with a slugging percentage of .465. All three of those stats lead St. Louis hitters this season. He's batting .330.
• Among qualifiers, he ranks sixth in batting average, 17th in on-base percentage and 46th in slugging percentage.
• Nolan Arenado is batting .247 with a .391 slugging percentage and 21 RBI this year.
• Willson Contreras has six home runs, 27 RBI and a batting average of .249 this season.
• Contreras enters this game on a two-game hitting streak. In his last five games he is hitting .190 with two doubles and two RBIs.

Tigers Player Leaders

• Spencer Torkelson is hitting .240 with 12 doubles, 12 home runs and 25 walks. He's slugging .520 with an on-base percentage of .345.
• Including all the qualifying hitters in the majors, he is 106th in batting average, 63rd in on-base percentage and 20th in slugging percentage.
• Riley Greene's 53 hits and .535 slugging percentage are both team-highs. He has a batting average of .286 with an on-base percentage of .337.
• Including all qualifying hitters, he ranks 35th in batting average, 67th in on-base percentage and 15th in slugging percentage.
• Gleyber Torres is batting .283 with six doubles, five home runs and 16 walks.
• Kerry Carpenter has six doubles, a triple, 10 home runs and five walks while hitting .283.

Cardinals vs Tigers Head to Head

• 5/20/2025: 5-4 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 5/19/2025: 11-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/1/2024: 4-1 DET (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/30/2024: 11-6 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2024: 2-1 STL (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/7/2023: 12-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 5/6/2023: 6-5 DET (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 5/5/2023: 5-4 DET (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -240, Underdog Moneyline: +198)

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