Cardinals vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for June 22

Odds updated as of 2:11 p.m.

The MLB slate on Sunday includes the Cincinnati Reds facing the St. Louis Cardinals.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Reds vs Cardinals Game Info

• Cincinnati Reds (39-38) vs. St. Louis Cardinals (42-35)
• Date: Sunday, June 22, 2025
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSOH

Reds vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-112) | STL: (-104)
• Spread: CIN: -1.5 (+136) | STL: +1.5 (-164)
• Total: 9.5 -- Over: (-100) | Under: (-122)

Reds vs Cardinals Probable Starting Pitchers

Probable Pitchers: Andrew Abbott (Reds) - 6-1, 1.84 ERA vs Miles Mikolas (Cardinals) - 4-4, 4.35 ERA

This contest's pitching matchup is set, as the Reds will send Andrew Abbott (6-1) to the mound, while Miles Mikolas (4-4) will take the ball for the Cardinals. Abbott and his team are 7-4-0 ATS this season when he starts. When Abbott starts a game and his team is the favorite on the moneyline, they have a record of 5-1. The Cardinals have a 7-7-0 record against the spread in Mikolas' starts. The Cardinals have been the moneyline underdog in 10 of Mikolas' starts this season, and they went 5-5 in those games.

Reds vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (50.6%)

Reds vs Cardinals Moneyline

• Cincinnati is a -112 favorite on the moneyline, while St. Louis is a -104 underdog at home.

Reds vs Cardinals Spread

• The Reds are favored by 1.5 runs on the road versus the Cardinals. The Reds are +136 to cover the spread, while the Cardinals are -164.

Reds vs Cardinals Over/Under

• An over/under of 9.5 has been set for Reds-Cardinals on June 22, with the over being -100 and the under -122.

Bet on Cincinnati Reds vs. St. Louis Cardinals on FanDuel today!

Reds vs Cardinals Betting Trends

• The Reds have won in 15, or 50%, of the 30 contests they have been named as odds-on favorites in this year.
• Cincinnati has a record of 13-14 when favored by -112 or more this year.
• The Reds and their opponents have gone over in 34 of their 73 games with a total set by sportsbooks this season.
• In 73 games with a line this season, the Reds have a mark of 38-35-0 against the spread.
• The Cardinals have won 22 of the 41 games they were the moneyline underdog this season (53.7%).
• St. Louis is 16-19 (winning 45.7% of its games) when it has played as a moneyline underdog of -104 or longer.
• The Cardinals have combined with opponents to go over the total 41 times this season for a 41-33-3 record against the over/under.
• The Cardinals have collected a 42-35-0 record ATS this season (covering 54.5% of the time).

Reds Player Leaders

• Elly De La Cruz leads Cincinnati in total hits (78) this season while batting .265 with 32 extra-base hits. He has an on-base percentage of .344 and a slugging percentage of .493.
• Among qualified batters in baseball, he ranks 61st in batting average, 58th in on-base percentage, and 25th in slugging.
• De La Cruz has hit safely in two games in a row. In his last five games he is batting .158 with a triple, a home run, two walks and two RBIs.
• TJ Friedl leads the Reds with an OPS of .815. He has a slash line of .289/.380/.436 this season.
• He is 24th in batting average, 18th in on-base percentage and 74th in slugging among qualifying hitters.
• Gavin Lux has collected 60 base hits, an OBP of .357 and a slugging percentage of .376 this season.
• Matt McLain has eight home runs, 26 RBI and a batting average of .209 this season.
• McLain has hit safely in nine straight games. In his last 10 games he is batting .375 with two doubles, a home run, four walks and four RBIs.

Cardinals Player Leaders

• Nolan Arenado has 11 doubles, a triple, 10 home runs and 23 walks while hitting .247. He's slugging .406 with an on-base percentage of .311.
• Including all the qualifying hitters in MLB, he is 105th in batting average, 110th in on-base percentage and 103rd in slugging percentage.
• Brendan Donovan has racked up 84 hits with a .382 OBP while slugging .435. Those stats all lead his team. He also has a batting average of .312.
• Including all qualifying hitters, he ranks ninth in batting average, 15th in on-base percentage and 75th in slugging percentage.
• Willson Contreras is batting .244 with 16 doubles, 10 home runs and 25 walks.
• Lars Nootbaar is batting .229 with 13 doubles, nine home runs and 43 walks.

Reds vs Cardinals Head to Head

• 6/21/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/20/2025: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/1/2025: 9-1 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/30/2025: 9-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2025: 6-0 STL (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/28/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/12/2024: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/11/2024: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/10/2024: 3-0 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/14/2024: 9-2 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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