Cardinals vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for April 8

Odds updated as of 3:11 p.m.

The MLB's Wednesday slate includes the St. Louis Cardinals facing the Washington Nationals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this game.

Cardinals vs Nationals Game Info

• St. Louis Cardinals (6-5) vs. Washington Nationals (4-7)
• Date: Wednesday, April 8, 2026
• Time: 4:05 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: Nationals.TV and Cardinals.TV

Cardinals vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-126) | WSH: (+108)
• Spread: STL: -1.5 (+132) | WSH: +1.5 (-160)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Cardinals vs Nationals Probable Starting Pitchers

Probable Pitchers: Michael McGreevy (Cardinals) - 0-1, 2.53 ERA vs Miles Mikolas (Nationals) - 0-2, 14.46 ERA

This contest's pitching matchup is set, as the Cardinals will send Michael McGreevy (0-1) to the mound, while Miles Mikolas (0-2) will get the nod for the Nationals. McGreevy has a record of 1-1-0 ATS in two starts with a spread this season. This will be McGreevy's first start this season with his team as the moneyline favorite. Mikolas has started two games with set spreads, and the Nationals failed to cover in both chances. The Nationals were the underdog on the moneyline for two Mikolas starts this season -- they lost both.

Cardinals vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.7%)

Cardinals vs Nationals Moneyline

• St. Louis is a -126 favorite on the moneyline, while Washington is a +108 underdog at home.

Cardinals vs Nationals Spread

• The Cardinals are favored by 1.5 runs on the road versus the Nationals. The Cardinals are +132 to cover the spread, while the Nationals are -160.

Cardinals vs Nationals Over/Under

• A total of 8.5 runs has been set for the Cardinals-Nationals game on April 8, with the over available at -118 and the under at -104.

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Cardinals vs Nationals Betting Trends

• The Cardinals were defeated in the one game they played as the favorite this season.
• These are the best odds of a victory sportsbooks have given St. Louis this season, with a -126 moneyline set for this game.
• Contests with the Cardinals have gone over the total set by bookmakers in six of 11 chances this season.
• The Cardinals are 5-6-0 against the spread in their 11 games that had a posted line this season.
• The Nationals have gone 4-6 in games they were listed as the moneyline underdog (winning 40% of those games).
• When playing as a moneyline underdog with odds of +108 or longer, Washington has gone 3-6 (33.3%).
• The Nationals have played in 11 games with an over/under set, and have combined with their opponents to go over the total nine times (9-2-0).
• The Nationals have put together a 7-4-0 record ATS this season (covering 63.6% of the time).

Cardinals Player Leaders

• Jordan Walker leads St. Louis with 12 hits and a team-best slugging percentage of .650. He's batting .300 with an on-base percentage of .364.
• Among all qualified hitters in MLB, his batting average ranks 34th, his on-base percentage ranks 47th, and he is 10th in slugging.
• Walker will look for his fifth straight game with a hit in this contest. During his last five outings he is batting .333 with three home runs, a walk and eight RBIs.
• Alec Burleson is batting .225 with two doubles, a home run and nine walks, while slugging .350 with an on-base percentage of .360.
• His batting average is 113th among qualified players, his on-base percentage 50th, and his slugging percentage 109th.
• JJ Wetherholt has 11 hits this season and a team-best OBP of .380.
• Wetherholt takes a four-game hitting streak into this matchup. During his last five outings he is hitting .250 with a double, five walks and an RBI.
• Ivan Herrera has been key for St. Louis with seven hits, an OBP of .353 plus a slugging percentage of .256.

Nationals Player Leaders

• C.J. Abrams has an on-base percentage of .413 and has 12 hits, both team-high figures for the Nationals. He's batting .308 and slugging .615.
• Including all the qualified hitters in MLB, his batting average ranks 29th, his on-base percentage is 18th, and he is 13th in slugging.
• Abrams heads into this game on an eight-game hitting streak. During his last 10 outings he is hitting .308 with four home runs, six walks and 14 RBIs.
• James Wood has three doubles, four home runs and eight walks while hitting .191. He's slugging .511 with an on-base percentage of .309.
• Including all qualifying hitters, his batting average places him 144th, his on-base percentage ranks 115th, and he is 40th in slugging.
• Luis Garcia is hitting .297 with three doubles, a triple, a home run and a walk.
• Joey Wiemer is batting .440 with a triple, two home runs and five walks.

Cardinals vs Nationals Head to Head

• 4/7/2026: 7-6 STL (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/6/2026: 9-6 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2025: 8-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/9/2025: 8-2 WSH (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/11/2025: 6-1 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/10/2025: 4-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/9/2025: 10-0 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/28/2024: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/27/2024: 14-3 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/26/2024: 10-8 WSH (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)

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